Polygenic Score (PGS) ID: PGS005234

Predicted Trait
Reported Trait Body size and adipose distribution
Mapped Trait(s)
Additional Trait Information Multivariate GWAS of 7 indicator variables relating to adult body size and adipose distribution
Released in PGS Catalog: Oct. 6, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name F3_Body_Size_and_Adipose_Distribution
Development Method
Name LDpred2-auto
Parameters Weights were calculated using the average posterior weights for the models that converged (causal variant thresholds: 30 evenly spaced values on a logarithmic scale ranging from 1E-4 to 0.9). 5,000 unrelated individuals of European ancestry from the UK Biobank were used as an LD reference panel
Variants
Original Genome Build GRCh38
Number of Variants 709,193
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000739
Citation (link to publication) Arehart CH et al. Nat Commun (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
690,110 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
690,110 individuals European EGG, GIANT, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022666 PSS012051|
European Ancestry|
100,960 individuals
 PGP000739 |
Arehart CH et al. Nat Commun (2025)
 Reported Trait: Atrial fibrillation (phecode: 427.21) OR: 1.16164 — — age, sex, batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —
PSS012051 — — 25,240 individuals — European — CCPM —