Polygenic Score (PGS) ID: PGS005366

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: Feb. 26, 2026
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Score Details

Score Construction
PGS Name DPRISM_T2DPRS_trainedforEAS_EURweights
Development Method
Name PRS-CSx
Parameters T2D GWAS summary statistics and LD reference panels (TagIt SNP set, 1000Gp3 LD estimations) from EUR ancestry. Best phi: 1e-3.
Variants
Original Genome Build hg19
Number of Variants 929,716
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000773
Citation (link to publication) Huerta-Chagoya A et al. medRxiv (2025) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,486,934 individuals (100%)
Score Development/Training
East Asian: 100%
2,837 individuals (100%)
PGS Evaluation
East Asian: 100%
7 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 30297969
[
  • 201,262 cases
  • , 1,285,672 controls
]
 European
(European American, Icelandic, French, Swedish, Estonian, Finish, German, British, Greek, Dutch, Danish)		 28 cohorts
  • BioMe
  • ,DGDG
  • ,DGI
  • ,EGCUT
  • ,FHS
  • ,FUSION
  • ,FinnGen
  • ,GCKD
  • ,GENOA
  • ,GERA
  • ,GOMAP
  • ,GoDARTS
  • ,HPFS
  • ,InterAct
  • ,KORA
  • ,MESA
  • ,METSIM
  • ,MGI
  • ,MVP
  • ,NHS
  • ,Nugene
  • ,PIVUS
  • ,PROSPER
  • ,RS
  • ,UKB
  • ,ULSAM
  • ,WTCCC
  • ,deCODE
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 906 cases
  • , 1,931 controls
]
 East Asian
(Japanese)		 BBJ — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023302 PSS012149|
East Asian Ancestry|
917 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 2.56 [2.11, 3.12]
β: 0.94195		 AUROC: 0.80354 R²: 0.32266 sex, age, genetic principal components —
PPM023307 PSS012152|
East Asian Ancestry|
2,846 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 2.25 [2.05, 2.48]
β: 0.81178		 AUROC: 0.72251 R²: 0.18468 sex, age, genetic principal components —
PPM023317 PSS012159|
East Asian Ancestry|
9,144 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 1.78 [1.66, 1.9]
β: 0.57569		 AUROC: 0.71515 R²: 0.14166 sex, age, genetic principal components —
PPM023322 PSS012160|
East Asian Ancestry|
13,197 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 2.86 [2.69, 3.04]
β: 1.05048		 AUROC: 0.79138 R²: 0.2399 sex, age, genetic principal components —
PPM023327 PSS012166|
East Asian Ancestry|
1,660 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 2.45 [2.12, 2.83]
β: 0.89724		 AUROC: 0.86 R²: 0.47165 sex, age, genetic principal components —
PPM023332 PSS012167|
East Asian Ancestry|
3,634 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 4.35 [3.89, 4.86]
β: 1.46928		 AUROC: 0.83429 R²: 0.41128 sex, age, genetic principal components —
PPM023312 PSS012154|
East Asian Ancestry|
804 individuals
 PGP000773 |
Huerta-Chagoya A et al. medRxiv (2025)
|Pre		 Reported Trait: Type 2 diabetes OR: 1.96 [1.6, 2.39]
β: 0.67233		 AUROC: 0.74954 R²: 0.20701 sex, age, genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012152 — —
[
  • 922 cases
  • , 1,924 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS012154 — —
[
  • 190 cases
  • , 614 controls
]
 — East Asian — BioMe —
PSS012159 — —
[
  • 1,200 cases
  • , 7,944 controls
]
 — East Asian
(Chinese)		 — CKB —
PSS012160 — —
[
  • 1,875 cases
  • , 11,322 controls
]
 — East Asian
(Korean)		 — KBA —
PSS012166 — —
[
  • 1,057 cases
  • , 603 controls
]
 — East Asian
(Chinese, Malay)		 — SDCS, SP2 —
PSS012167 — —
[
  • 2,354 cases
  • , 1,280 controls
]
 — East Asian
(Korean)		 — SNUH —
PSS012149 — —
[
  • 252 cases
  • , 665 controls
]
 — East Asian — AllofUs —