Polygenic Score (PGS) ID: PGS005387

Predicted Trait
Reported Trait Triple-negative breast cancer
Mapped Trait(s) triple-negative breast cancer (EFO_0005537)
Released in PGS Catalog: Feb. 26, 2026
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Score Details

Score Construction
PGS Name TNBC_162_M2
Development Method
Name Lassosum2
Parameters LD r2 < 0.9, Lassosum2 was implemented for HapMap3 variants with default parameters for L1-regularization
Variants
Original Genome Build hg38
Number of Variants 162
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000774
Citation (link to publication) Li JL et al. Nat Genet (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
African: 100%
25,334 individuals (100%)
Score Development/Training
African: 100%
28,953 individuals (100%)
PGS Evaluation
African: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 12,174 cases
  • , 13,160 controls
]
,
0.0 % Male samples
 African American or Afro-Caribbean
(African)		 6 cohorts
  • AABC
  • ,AABCG
  • ,AMBER
  • ,BCAC
  • ,GBHS
  • ,ROOT
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 13,913 cases
  • , 15,040 controls
]
,
0.0 % Male samples
 African American or Afro-Caribbean
(African)		 6 cohorts
  • AABC
  • ,AABCG
  • ,AMBER
  • ,BCAC
  • ,GBHS
  • ,ROOT
 — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023413 PSS012170|
African Ancestry|
4,285 individuals
 PGP000774 |
Li JL et al. Nat Genet (2026)
 Reported Trait: triple negative breast cancer risk OR: 1.6 [1.45, 1.76] AUROC: 0.628 [0.601, 0.651] — — —
PPM023425 PSS012169|
African Ancestry|
3,112 individuals
 PGP000774 |
Li JL et al. Nat Genet (2026)
 Reported Trait: triple negative breast cancer risk — AUROC: 0.642 [0.585, 0.701] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012169 — —
[
  • 101 cases
  • , 3,011 controls
]
,
0.0 % Male samples
 — African American or Afro-Caribbean
(African)		 — BEST_Florida, BioVU, WFBC —
PSS012170 — —
[
  • 525 cases
  • , 3,760 controls
]
,
0.0 % Male samples
 — African American or Afro-Caribbean
(African)		 — 6 cohorts
  • AABC
  • ,AABCG
  • ,AMBER
  • ,BCAC
  • ,GBHS
  • ,ROOT
 —