Polygenic Score (PGS) ID: PGS012530

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disorder (MONDO_0005010)
Released in PGS Catalog: July 15, 2026
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Terms and Licenses
This PRS model is provided for academic research purposes only, not-for-profit use.

Score Details

Score Construction
PGS Name PRSCAD+
Development Method
Name PRS-CSx and LASSO COX model
Parameters φ=10-6, 10-4, 10-2 and 1
Variants
Original Genome Build GRCh38
Number of Variants 1,083,724
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000787
Citation (link to publication) Wang H et al. Genomics Proteomics Bioinformatics (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72.4%
East Asian: 24.9%
Not Reported: 2.8%
16,689,644 individuals (100%)
Score Development/Training
East Asian: 100%
8,756 individuals (100%)
PGS Evaluation
East Asian: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006901
Europe PMC: 30124842
 456,426 individuals European NR
GWAS Catalog: GCST90013687
Europe PMC: 32514122
 212,453 individuals East Asian BBJ
Europe PMC: 41092961
[
  • 37,139 cases
  • , 297,646 controls
]
 East Asian TPMI
Europe PMC: 30305743
[
  • 39,781 cases
  • , 400,717 controls
]
 European UKB
Europe PMC: 36653562
[
  • 84,088 cases
  • , 416,260 controls
]
 European FinnGen
Europe PMC: 26343387
[
  • 60,801 cases
  • , 123,504 controls
]
 European CARDIoGRAMplusC4D
GWAS Catalog: GCST90255478
Europe PMC: 36777999
 237,344 individuals East Asian BBJ, KoGES
GWAS Catalog: GCST006901
Europe PMC: 30124842
 237,103 individuals Not reported NR
GWAS Catalog: GCST90255480
Europe PMC: 36777999
 236,117 individuals East Asian BBJ, KoGES
Europe PMC: 41092961
 191,458 individuals East Asian TPMI
GWAS Catalog: GCST006900
Europe PMC: 30124842
 224,849 individuals Not reported NR
GWAS Catalog: GCST006900
Europe PMC: 30124842
 456,426 individuals European NR
GWAS Catalog: GCST90255482
Europe PMC: 36777999
 204,034 individuals East Asian BBJ, KoGES
— 314,916 individuals European UKB
GWAS Catalog: GCST90239651
Europe PMC: 34887591
 146,492 individuals East Asian 24 cohorts
  • BAS
  • ,BBJ
  • ,BES
  • ,CAGE
  • ,CAS
  • ,CHNS
  • ,CKB
  • ,JPDSC
  • ,KARE
  • ,Living-Biobank
  • ,MESA
  • ,NHAPC
  • ,Nagahama Study
  • ,Other
  • ,SBCS
  • ,SCES
  • ,SCHS
  • ,SDCS
  • ,SIMES
  • ,SINDI
  • ,SP2
  • ,SWHS
  • ,TUDR
  • ,TWT2D
GWAS Catalog: GCST90239652
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90239658
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90239657
Europe PMC: 34887591
 146,492 individuals East Asian 24 cohorts
  • BAS
  • ,BBJ
  • ,BES
  • ,CAGE
  • ,CAS
  • ,CHNS
  • ,CKB
  • ,JPDSC
  • ,KARE
  • ,Living-Biobank
  • ,MESA
  • ,NHAPC
  • ,Nagahama Study
  • ,Other
  • ,SBCS
  • ,SCES
  • ,SCHS
  • ,SDCS
  • ,SIMES
  • ,SINDI
  • ,SP2
  • ,SWHS
  • ,TUDR
  • ,TWT2D
GWAS Catalog: GCST90239663
Europe PMC: 34887591
 146,492 individuals East Asian 24 cohorts
  • BAS
  • ,BBJ
  • ,BES
  • ,CAGE
  • ,CAS
  • ,CHNS
  • ,CKB
  • ,JPDSC
  • ,KARE
  • ,Living-Biobank
  • ,MESA
  • ,NHAPC
  • ,Nagahama Study
  • ,Other
  • ,SBCS
  • ,SCES
  • ,SCHS
  • ,SDCS
  • ,SIMES
  • ,SINDI
  • ,SP2
  • ,SWHS
  • ,TUDR
  • ,TWT2D
GWAS Catalog: GCST90239664
Europe PMC: 34887591
 1,320,016 individuals European Multiple
Europe PMC: 41092961
 160,000 individuals East Asian TPMI
GWAS Catalog: GCST90255477
Europe PMC: 36777999
 217,780 individuals East Asian BBJ, KoGES
GWAS Catalog: GCST90310294
Europe PMC: 38689001
 1,028,980 individuals European BioVU, ICBP, MVP, UKB
GWAS Catalog: GCST90310295
Europe PMC: 38689001
 1,028,980 individuals European BioVU, ICBP, MVP, UKB
GWAS Catalog: GCST90255476
Europe PMC: 36777999
 217,780 individuals East Asian BBJ, KoGES
Europe PMC: 41092961
 196,200 individuals East Asian TPMI
— 136,597 individuals East Asian BBJ
GWAS Catalog: GCST006626
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90255495
Europe PMC: 36777999
 207,876 individuals East Asian BBJ, KoGES
Europe PMC: 41092961
 173,813 individuals East Asian TPMI
— 350,475 individuals European UKB
GWAS Catalog: GCST90255497
Europe PMC: 36777999
 223,090 individuals East Asian BBJ, KoGES
GWAS Catalog: GCST90255496
Europe PMC: 36777999
 223,090 individuals East Asian BBJ, KoGES
Europe PMC: 27346685
 444,410 individuals European BCX
— 109,029 individuals East Asian BBJ
— 343,836 individuals European UKB
GWAS Catalog: GCST90492734
Europe PMC: 38374256
[
  • 88,109 cases
  • , 339,395 controls
]
 East Asian T2D-GGI
GWAS Catalog: GCST90492734
Europe PMC: 38374256
[
  • 242,283 cases
  • , 1,569,734 controls
]
 European T2D-GGI
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 2,299 cases
  • , 6,457 controls
]
,
43.59 % Male samples
 East Asian
(Chinese)		 DFTJ I20-I25 Mean = 62.0 years — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030614 PSS012202|
East Asian Ancestry|
12,127 individuals
 PGP000787 |
Wang H et al. Genomics Proteomics Bioinformatics (2026)
 Reported Trait: coronary artery disease HR: 1.26 C-index: 0.649 — age, sex, and the first four PCs —
PPM030615 PSS012203|
East Asian Ancestry|
5,243 individuals
 PGP000787 |
Wang H et al. Genomics Proteomics Bioinformatics (2026)
 Reported Trait: coronary artery disease OR: 2.23 AUROC: 0.786 — age, sex, and the first four PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012202 I20-I25 —
[
  • 2,360 cases
  • , 9,767 controls
]
,
43.33 % Male samples
 Mean = 60.0 years East Asian
(Chinese)		 — DFTJ —
PSS012203 CAD was defined by coronary angiography as ≥50% stenosis in ≥1 major coronary artery, which manifested as occult CAD —
[
  • 2,681 cases
  • , 2,562 controls
]
,
64.3 % Male samples
 Mean = 58.0 years East Asian
(Chinese)		 — GRAND —