Polygenic Score (PGS) ID: PGS012538

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (MONDO_0004981)
Released in PGS Catalog: June 17, 2026
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name UKB_Mult-t-SAS
Development Method
Name SBayesRC
Parameters Inputs: GWAS summary statistics, LD reference panel, and annotation file; no additional parameters specified.
Variants
Original Genome Build GRCh38
Number of Variants 7,356,497
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000788
Citation (link to publication) Haydarlou P et al. Nat Commun (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 69.9%
Multi-ancestry (including European): 15.5%
  • European
  • Hispanic or Latin American
  • African
  • South Asian
  • East Asian
East Asian: 6%
African: 5.7%
Hispanic or Latin American: 2.9%
South Asian: 0.01%
7,030,538 individuals (100%)
Score Development/Training
East Asian: 100%
19,459 individuals (100%)

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 11,138 individuals African American or Afro-Caribbean 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 148,865 individuals East Asian 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 1,480,272 individuals European 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 9,439 individuals Hispanic or Latin American 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 631 individuals South Asian 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 118,682 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 58,834 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 6,743 individuals East Asian MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 437,748 individuals European MVP
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 1,893,921 individuals European 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 142,872 individuals African unspecified 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 257,928 individuals East Asian 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 63,835 individuals Hispanic or Latin American 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
[
  • 243,392 cases
  • , 849,686 controls
]
 European, Hispanic or Latin American, African American or Afro-Caribbean, South Asian, East Asian BBJ, CARDIoGRAMplusC4D, MVP, UKB
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 119,331 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 57,988 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 6,420 individuals East Asian MVP
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 425,740 individuals European MVP
GWAS Catalog: GCST90435415
Europe PMC: 39134668
 404,507 individuals European UKB
GWAS Catalog: GCST010321
Europe PMC: 32439900
 271,570 individuals European Multiple
GWAS Catalog: GCST010321
Europe PMC: 32439900
 8,173 individuals African American or Afro-Caribbean Multiple
GWAS Catalog: GCST010321
Europe PMC: 32439900
 12,823 individuals Hispanic or Latin American Multiple
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 1,756 cases
  • , 17,703 controls
]
 East Asian
(Japanese)		 BBJ physician's diagnosis or electrocardiogram records — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information