Polygenic Score (PGS) ID: PGS012550

Predicted Trait
Reported Trait Idiopathic pulmonary fibrosis
Mapped Trait(s) idiopathic pulmonary fibrosis (EFO_0000768)
Released in PGS Catalog: April 13, 2026
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Score Details

Score Construction
PGS Name PRS13_IPF
Development Method
Name Genome-wide significant SNPs
Parameters P < 5E-08, MAF>0.05
Variants
Original Genome Build NR
Number of Variants 13
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000793
Citation (link to publication) Tang L et al. Environ Res (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
11,259 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
  • Additional Asian Ancestries
  • African
  • East Asian
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009758
Europe PMC: 31710517
 11,259 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030659 PSS012226|
Multi-ancestry (including European)|
466,155 individuals
 PGP000793 |
Tang L et al. Environ Res (2023)
 Reported Trait: Incident idiopathic pulmonary fibrosis HR: 1.7 [1.62, 1.78] — — age, gender, ethnicity, annual household income, education level, employment status, residential area, smoking status, alcohol consumption, genotyping batch and the first ten genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012226 — — 423,648 individuals — European — UKB —
PSS012226 — — 21,839 individuals — Not reported — UKB —
PSS012226 — — 16,500 individuals — Asian unspecified — UKB —
PSS012226 — — 2,659 individuals — African American or Afro-Caribbean
(Black)		 — UKB —
PSS012226 — — 1,509 individuals — East Asian
(Chinese)		 — UKB —