Polygenic Score (PGS) ID: PGS019120

Predicted Trait
Reported Trait Sensorineural hearing loss
Mapped Trait(s) sensorineural hearing loss disorder (MONDO_0020678)
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name TPMI_389.1_SBayesR
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 976,192
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000835
Citation (link to publication) Chen HH et al. Nature (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
323,446 individuals (100%)
Score Development/Training
East Asian: 100%
75,181 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 10,106 cases
  • , 313,340 controls
]
,
44.42 % Male samples
 East Asian
(Han Chinese)		 TPMI
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 2,901 cases
  • , 72,280 controls
]
,
46.14 % Male samples
 East Asian
(Han Chinese)		 TPMI 388.3,H93.1, H93.A, H93.A1, H93.A2, H93.A3, H93.A9 — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037302 PSS013017|
East Asian Ancestry|
18,218 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sensorineural hearing loss — AUROC: 0.59804 R²: 0.00448 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013017 389.1,H90.3, H90.4, H90.5, H90.A2, H90.A21, H90.A22 —
[
  • 267 cases
  • , 17,951 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —