Polygenic Score (PGS) ID: PGS019523

Predicted Trait
Reported Trait Hyperplasia of prostate
Mapped Trait(s) benign prostatic hyperplasia (MONDO_0010811)
Released in PGS Catalog: July 29, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name TPMI_600_LDpred2
Development Method
Name LDpred2
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 939,823
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000835
Citation (link to publication) Chen HH et al. Nature (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
142,997 individuals (100%)
Score Development/Training
East Asian: 100%
34,891 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 31,165 cases
  • , 111,832 controls
]
,
100.0 % Male samples
 East Asian
(Han Chinese)		 TPMI
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 8,383 cases
  • , 26,508 controls
]
,
100.0 % Male samples
 East Asian
(Han Chinese)		 TPMI 600,N40, N42.83 — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037705 PSS013424|
East Asian Ancestry|
8,710 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperplasia of prostate — AUROC: 0.57495 R²: 0.01379 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013424 600,N40, N42.83 —
[
  • 2,100 cases
  • , 6,610 controls
]
,
100.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —