Polygenic Score (PGS) ID: PGS019905

Predicted Trait
Reported Trait Triglycerides
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name TPMI_TG_MegaPRS
Development Method
Name MegaPRS
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 404,202
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000835
Citation (link to publication) Chen HH et al. Nature (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
161,062 individuals (100%)
Score Development/Training
East Asian: 100%
39,185 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 161,062 individuals,
45.01 % Male samples
 East Asian
(Han Chinese)		 TPMI
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 39,185 individuals,
46.78 % Male samples
 East Asian
(Han Chinese)		 TPMI 0 — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038087 PSS013800|
East Asian Ancestry|
9,697 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Triglycerides — AUROC: 0.78845 R²: 0.09959 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013800 — — 9,697 individuals,
46.91 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —