Trait: hypertension

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000537
Description Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more. [MESH: D006973]
Trait category
Cardiovascular disease
Synonyms 25 synonyms
  • (hypertensive disease) or (hypertension)
  • Blood Pressure, High
  • Blood Pressures, High
  • HTN
  • HTN - hypertension
  • HYPERTENSIVE DISEASE
  • High Blood Pressure
  • High Blood Pressures
  • High blood pressure (& [essential hypertension])
  • Hypertensive disease (disorder)
  • Hypertensive disease NOS (disorder)
  • SURG COMP - HYPERTENSION
  • [X]Hypertensive diseases
  • [X]Hypertensive diseases (disorder)
  • blood pressure, high
  • blood pressure, increased
  • high blood pressure
  • hyperpiesia
  • hypertension NOS
  • hypertensive disease
  • hypertensive disease NOS
  • hypertensive disorder
  • increased blood pressure
  • pressure, high blood
  • vascular hypertensive disorder
Mapped term(s) 17 mapped terms
  • DOID:10763
  • HP:0000822
  • ICD10:I10
  • ICD10:I10-I15
  • ICD10:I15
  • ICD10:O10
  • ICD10:O11
  • ICD9:401-405.99
  • ICD9:997.91
  • MESH:D006973
  • MONDO:0005044
  • MeSH:D006973
  • NCIT:C3117
  • NCIt:C3117
  • OMIM:145500
  • SCTID:38341003
  • UMLS:C0020538

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000706
(HC215)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Hypertension hypertension 186,726
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000706/ScoringFiles/PGS000706.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001598 PGS000706
(HC215)
PSS000822|
European Ancestry|
87,413 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Hypertension AUROC: 0.623 Age, sex, PCs(1-10)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000822 87,413 individuals European UKB