Trait: hypertension

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000537
Description Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more. [MESH: D006973]
Trait category
Cardiovascular disease
Synonyms 25 synonyms
  • (hypertensive disease) or (hypertension)
  • Blood Pressure, High
  • Blood Pressures, High
  • HTN
  • HTN - hypertension
  • HYPERTENSIVE DISEASE
  • High Blood Pressure
  • High Blood Pressures
  • High blood pressure (& [essential hypertension])
  • Hypertensive disease (disorder)
  • Hypertensive disease NOS (disorder)
  • SURG COMP - HYPERTENSION
  • [X]Hypertensive diseases
  • [X]Hypertensive diseases (disorder)
  • blood pressure, high
  • blood pressure, increased
  • high blood pressure
  • hyperpiesia
  • hypertension NOS
  • hypertensive disease
  • hypertensive disease NOS
  • hypertensive disorder
  • increased blood pressure
  • pressure, high blood
  • vascular hypertensive disorder
Mapped terms 17 mapped terms
  • DOID:10763
  • HP:0000822
  • ICD10:O10
  • ICD10:O11
  • ICD10CM:I10-I16
  • ICD10CM:I15
  • ICD9:401-405.99
  • ICD9:997.91
  • MESH:D006973
  • MONDO:0005044
  • MeSH:D006973
  • MedDRA:10020772
  • NCIT:C3117
  • NCIt:C3117
  • OMIM:145500
  • SCTID:38341003
  • UMLS:C0020538
Child trait(s) essential hypertension

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "hypertension" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000706
(HC215)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Hypertension hypertension 186,726
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000706/ScoringFiles/PGS000706.txt.gz - Check Terms/Licenses
PGS000957
(GBE_HC932)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Essential (primary hypertension) (time-to-event) essential hypertension 11,276
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000957/ScoringFiles/PGS000957.txt.gz
PGS000958
(GBE_HC273)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Essential hypertension essential hypertension 9,400
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000958/ScoringFiles/PGS000958.txt.gz
PGS001320
(GBE_HC215)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Hypertension hypertension 13,791
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001320/ScoringFiles/PGS001320.txt.gz
PGS001838
(portability-PLR_401)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Hypertension hypertension 52,487
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001838/ScoringFiles/PGS001838.txt.gz
PGS002047
(portability-ldpred2_401)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Hypertension hypertension 918,325
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002047/ScoringFiles/PGS002047.txt.gz
PGS002296
(PRS2166_HT)
PGP000326 |
Maj C et al. Front Cardiovasc Med (2022)
Hypertension hypertension 2,166
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002296/ScoringFiles/PGS002296.txt.gz
PGS002335
(disease_HYPERTENSION_DIAGNOSED.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002335/ScoringFiles/PGS002335.txt.gz
PGS002407
(disease_HYPERTENSION_DIAGNOSED.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 6,693
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002407/ScoringFiles/PGS002407.txt.gz
PGS002456
(disease_HYPERTENSION_DIAGNOSED.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 22,539
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002456/ScoringFiles/PGS002456.txt.gz
PGS002505
(disease_HYPERTENSION_DIAGNOSED.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 115,656
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002505/ScoringFiles/PGS002505.txt.gz
PGS002554
(disease_HYPERTENSION_DIAGNOSED.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 1,715
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002554/ScoringFiles/PGS002554.txt.gz
PGS002603
(disease_HYPERTENSION_DIAGNOSED.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 949
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002603/ScoringFiles/PGS002603.txt.gz
PGS002652
(disease_HYPERTENSION_DIAGNOSED.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 385,766
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002652/ScoringFiles/PGS002652.txt.gz
PGS002701
(disease_HYPERTENSION_DIAGNOSED.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Hypertension hypertension 973,782
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002701/ScoringFiles/PGS002701.txt.gz
PGS002765
(SBP_prscs)
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Hypertension hypertension 1,077,894
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002765/ScoringFiles/PGS002765.txt.gz
PGS002994
(ExPRSweb_Hypertension_20002-1065_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 724,579
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002994/ScoringFiles/PGS002994.txt.gz
PGS002995
(ExPRSweb_Hypertension_20002-1065_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 26,671
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002995/ScoringFiles/PGS002995.txt.gz
PGS002996
(ExPRSweb_Hypertension_20002-1065_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 25,909
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002996/ScoringFiles/PGS002996.txt.gz
PGS002997
(ExPRSweb_Hypertension_20002-1065_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 7,601,215
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002997/ScoringFiles/PGS002997.txt.gz
PGS002998
(ExPRSweb_Hypertension_20002-1065_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 1,113,832
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002998/ScoringFiles/PGS002998.txt.gz
PGS002999
(ExPRSweb_Hypertension_20002-1072_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 313,080
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002999/ScoringFiles/PGS002999.txt.gz
PGS003000
(ExPRSweb_Hypertension_20002-1072_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 83,829
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003000/ScoringFiles/PGS003000.txt.gz
PGS003001
(ExPRSweb_Hypertension_20002-1072_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 81,218
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003001/ScoringFiles/PGS003001.txt.gz
PGS003002
(ExPRSweb_Hypertension_20002-1072_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 7,601,215
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003002/ScoringFiles/PGS003002.txt.gz
PGS003003
(ExPRSweb_Hypertension_20002-1072_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 1,109,030
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003003/ScoringFiles/PGS003003.txt.gz
PGS003004
(ExPRSweb_Hypertension_finngen-R4-FG_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 4,943
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003004/ScoringFiles/PGS003004.txt.gz
PGS003005
(ExPRSweb_Hypertension_finngen-R4-FG_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 2,860
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003005/ScoringFiles/PGS003005.txt.gz
PGS003006
(ExPRSweb_Hypertension_finngen-R4-FG_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 5,212
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003006/ScoringFiles/PGS003006.txt.gz
PGS003007
(ExPRSweb_Hypertension_finngen-R4-FG_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 359
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003007/ScoringFiles/PGS003007.txt.gz
PGS003008
(ExPRSweb_Hypertension_finngen-R4-FG_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 12,076
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003008/ScoringFiles/PGS003008.txt.gz
PGS003009
(ExPRSweb_Hypertension_finngen-R4-I9_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 5,226
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003009/ScoringFiles/PGS003009.txt.gz
PGS003010
(ExPRSweb_Hypertension_finngen-R4-I9_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 1,894
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003010/ScoringFiles/PGS003010.txt.gz
PGS003011
(ExPRSweb_Hypertension_finngen-R4-I9_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 3,300
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003011/ScoringFiles/PGS003011.txt.gz
PGS003012
(ExPRSweb_Hypertension_finngen-R4-I9_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 361
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003012/ScoringFiles/PGS003012.txt.gz
PGS003013
(ExPRSweb_Hypertension_finngen-R4-I9_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 12,076
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003013/ScoringFiles/PGS003013.txt.gz
PGS003014
(ExPRSweb_Hypertension_I10_LASSOSUM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 294,142
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003014/ScoringFiles/PGS003014.txt.gz
PGS003015
(ExPRSweb_Hypertension_I10_PT_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 58,725
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003015/ScoringFiles/PGS003015.txt.gz
PGS003016
(ExPRSweb_Hypertension_I10_PLINK_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 56,978
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003016/ScoringFiles/PGS003016.txt.gz
PGS003017
(ExPRSweb_Hypertension_I10_DBSLMM_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 7,094,727
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003017/ScoringFiles/PGS003017.txt.gz
PGS003018
(ExPRSweb_Hypertension_I10_PRSCS_MGI_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 1,096,197
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003018/ScoringFiles/PGS003018.txt.gz
PGS003019
(ExPRSweb_Hypertension_finngen-R4-FG_LASSOSUM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 6,731
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003019/ScoringFiles/PGS003019.txt.gz
PGS003020
(ExPRSweb_Hypertension_finngen-R4-FG_PT_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 24
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003020/ScoringFiles/PGS003020.txt.gz
PGS003021
(ExPRSweb_Hypertension_finngen-R4-FG_PLINK_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 24
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003021/ScoringFiles/PGS003021.txt.gz
PGS003022
(ExPRSweb_Hypertension_finngen-R4-FG_DBSLMM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 56
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003022/ScoringFiles/PGS003022.txt.gz
PGS003023
(ExPRSweb_Hypertension_finngen-R4-FG_PRSCS_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 12,097
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003023/ScoringFiles/PGS003023.txt.gz
PGS003024
(ExPRSweb_Hypertension_finngen-R4-I9_LASSOSUM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 7,123
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003024/ScoringFiles/PGS003024.txt.gz
PGS003025
(ExPRSweb_Hypertension_finngen-R4-I9_PT_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 9
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003025/ScoringFiles/PGS003025.txt.gz
PGS003026
(ExPRSweb_Hypertension_finngen-R4-I9_PLINK_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 9
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003026/ScoringFiles/PGS003026.txt.gz
PGS003027
(ExPRSweb_Hypertension_finngen-R4-I9_DBSLMM_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 59
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003027/ScoringFiles/PGS003027.txt.gz
PGS003028
(ExPRSweb_Hypertension_finngen-R4-I9_PRSCS_UKB_20211120)
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Hypertension hypertension 12,097
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003028/ScoringFiles/PGS003028.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001598 PGS000706
(HC215)
PSS000822|
European Ancestry|
87,413 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Hypertension AUROC: 0.623 Age, sex, PCs(1-10)
PPM007609 PGS000957
(GBE_HC932)
PSS004711|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE essential (primary hypertension) AUROC: 0.71865 [0.70527, 0.73203] : 0.17042
Incremental AUROC (full-covars): -0.00133
PGS R2 (no covariates): 0.00389
PGS AUROC (no covariates): 0.53092 [0.51597, 0.54587]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007610 PGS000957
(GBE_HC932)
PSS004712|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE essential (primary hypertension) AUROC: 0.7519 [0.72118, 0.78262] : 0.18828
Incremental AUROC (full-covars): 0.01726
PGS R2 (no covariates): 0.02831
PGS AUROC (no covariates): 0.59059 [0.55566, 0.62552]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007611 PGS000957
(GBE_HC932)
PSS004713|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE essential (primary hypertension) AUROC: 0.74724 [0.74015, 0.75433] : 0.19436
Incremental AUROC (full-covars): 0.02015
PGS R2 (no covariates): 0.03223
PGS AUROC (no covariates): 0.60027 [0.59183, 0.6087]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007612 PGS000957
(GBE_HC932)
PSS004714|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE essential (primary hypertension) AUROC: 0.73072 [0.71892, 0.74253] : 0.19598
Incremental AUROC (full-covars): 0.00857
PGS R2 (no covariates): 0.01913
PGS AUROC (no covariates): 0.56924 [0.55569, 0.58279]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007613 PGS000957
(GBE_HC932)
PSS004715|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE essential (primary hypertension) AUROC: 0.72352 [0.71925, 0.72779] : 0.16706
Incremental AUROC (full-covars): 0.02959
PGS R2 (no covariates): 0.04055
PGS AUROC (no covariates): 0.60837 [0.60349, 0.61326]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007614 PGS000958
(GBE_HC273)
PSS004403|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Essential hypertension AUROC: 0.72155 [0.708, 0.7351] : 0.17503
Incremental AUROC (full-covars): -0.00192
PGS R2 (no covariates): 0.00286
PGS AUROC (no covariates): 0.52821 [0.51311, 0.54331]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007615 PGS000958
(GBE_HC273)
PSS004404|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Essential hypertension AUROC: 0.74478 [0.71204, 0.77751] : 0.16987
Incremental AUROC (full-covars): 0.01358
PGS R2 (no covariates): 0.01557
PGS AUROC (no covariates): 0.56972 [0.5318, 0.60763]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007616 PGS000958
(GBE_HC273)
PSS004405|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Essential hypertension AUROC: 0.74583 [0.73846, 0.75319] : 0.1847
Incremental AUROC (full-covars): 0.01683
PGS R2 (no covariates): 0.02709
PGS AUROC (no covariates): 0.59474 [0.58596, 0.60351]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007617 PGS000958
(GBE_HC273)
PSS004406|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Essential hypertension AUROC: 0.73161 [0.71966, 0.74357] : 0.19538
Incremental AUROC (full-covars): 0.00693
PGS R2 (no covariates): 0.01804
PGS AUROC (no covariates): 0.56789 [0.55414, 0.58165]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007618 PGS000958
(GBE_HC273)
PSS004407|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Essential hypertension AUROC: 0.72364 [0.71923, 0.72805] : 0.16114
Incremental AUROC (full-covars): 0.02564
PGS R2 (no covariates): 0.03436
PGS AUROC (no covariates): 0.60148 [0.5964, 0.60656]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009092 PGS001320
(GBE_HC215)
PSS004349|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hypertension AUROC: 0.7113 [0.69875, 0.72385] : 0.17724
Incremental AUROC (full-covars): 0.00194
PGS R2 (no covariates): 0.01116
PGS AUROC (no covariates): 0.55174 [0.53775, 0.56573]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009093 PGS001320
(GBE_HC215)
PSS004350|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hypertension AUROC: 0.75955 [0.7336, 0.78551] : 0.22552
Incremental AUROC (full-covars): 0.03121
PGS R2 (no covariates): 0.05514
PGS AUROC (no covariates): 0.62221 [0.59228, 0.65214]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009094 PGS001320
(GBE_HC215)
PSS004351|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hypertension AUROC: 0.731 [0.72434, 0.73765] : 0.19145
Incremental AUROC (full-covars): 0.03394
PGS R2 (no covariates): 0.05533
PGS AUROC (no covariates): 0.62108 [0.61358, 0.62857]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009095 PGS001320
(GBE_HC215)
PSS004352|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hypertension AUROC: 0.73444 [0.72324, 0.74564] : 0.21325
Incremental AUROC (full-covars): 0.02055
PGS R2 (no covariates): 0.03841
PGS AUROC (no covariates): 0.59979 [0.58706, 0.61252]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009096 PGS001320
(GBE_HC215)
PSS004353|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hypertension AUROC: 0.7189 [0.71489, 0.72291] : 0.17852
Incremental AUROC (full-covars): 0.04424
PGS R2 (no covariates): 0.06493
PGS AUROC (no covariates): 0.62908 [0.62467, 0.63349]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009594 PGS001838
(portability-PLR_401)
PSS009310|
European Ancestry|
20,000 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1882 [0.1748, 0.2016] sex, age, birth date, deprivation index, 16 PCs
PPM009595 PGS001838
(portability-PLR_401)
PSS009084|
European Ancestry|
4,136 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1633 [0.1334, 0.1929] sex, age, birth date, deprivation index, 16 PCs
PPM009596 PGS001838
(portability-PLR_401)
PSS008638|
European Ancestry|
6,660 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.157 [0.1335, 0.1804] sex, age, birth date, deprivation index, 16 PCs
PPM009598 PGS001838
(portability-PLR_401)
PSS008192|
South Asian Ancestry|
6,331 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1567 [0.1326, 0.1807] sex, age, birth date, deprivation index, 16 PCs
PPM009599 PGS001838
(portability-PLR_401)
PSS007974|
East Asian Ancestry|
1,810 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1165 [0.0706, 0.162] sex, age, birth date, deprivation index, 16 PCs
PPM009600 PGS001838
(portability-PLR_401)
PSS007757|
African Ancestry|
2,484 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1101 [0.071, 0.149] sex, age, birth date, deprivation index, 16 PCs
PPM009601 PGS001838
(portability-PLR_401)
PSS008861|
African Ancestry|
3,924 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.0682 [0.0369, 0.0993] sex, age, birth date, deprivation index, 16 PCs
PPM009597 PGS001838
(portability-PLR_401)
PSS008412|
Greater Middle Eastern Ancestry|
1,200 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1797 [0.1239, 0.2344] sex, age, birth date, deprivation index, 16 PCs
PPM011238 PGS002047
(portability-ldpred2_401)
PSS009310|
European Ancestry|
20,000 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1966 [0.1832, 0.2099] sex, age, birth date, deprivation index, 16 PCs
PPM011239 PGS002047
(portability-ldpred2_401)
PSS009084|
European Ancestry|
4,136 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1843 [0.1546, 0.2137] sex, age, birth date, deprivation index, 16 PCs
PPM011241 PGS002047
(portability-ldpred2_401)
PSS008412|
Greater Middle Eastern Ancestry|
1,200 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1675 [0.1115, 0.2224] sex, age, birth date, deprivation index, 16 PCs
PPM011242 PGS002047
(portability-ldpred2_401)
PSS008192|
South Asian Ancestry|
6,331 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1679 [0.1438, 0.1917] sex, age, birth date, deprivation index, 16 PCs
PPM011243 PGS002047
(portability-ldpred2_401)
PSS007974|
East Asian Ancestry|
1,810 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1101 [0.0641, 0.1556] sex, age, birth date, deprivation index, 16 PCs
PPM011244 PGS002047
(portability-ldpred2_401)
PSS007757|
African Ancestry|
2,484 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.0996 [0.0603, 0.1385] sex, age, birth date, deprivation index, 16 PCs
PPM011245 PGS002047
(portability-ldpred2_401)
PSS008861|
African Ancestry|
3,924 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.0804 [0.0492, 0.1115] sex, age, birth date, deprivation index, 16 PCs
PPM011240 PGS002047
(portability-ldpred2_401)
PSS008638|
European Ancestry|
6,660 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hypertension Partial Correlation (partial-r): 0.1669 [0.1434, 0.1902] sex, age, birth date, deprivation index, 16 PCs
PPM013025 PGS002296
(PRS2166_HT)
PSS009654|
European Ancestry|
2,244 individuals
PGP000326 |
Maj C et al. Front Cardiovasc Med (2022)
Reported Trait: Hypertension OR: 3.22 [2.06, 5.1]
PPM013149 PGS002335
(disease_HYPERTENSION_DIAGNOSED.BOLT-LMM)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0326 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013100 PGS002335
(disease_HYPERTENSION_DIAGNOSED.BOLT-LMM)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0144 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013198 PGS002335
(disease_HYPERTENSION_DIAGNOSED.BOLT-LMM)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0527 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013247 PGS002335
(disease_HYPERTENSION_DIAGNOSED.BOLT-LMM)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0444 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013388 PGS002407
(disease_HYPERTENSION_DIAGNOSED.P+T.0.0001)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013437 PGS002407
(disease_HYPERTENSION_DIAGNOSED.P+T.0.0001)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0023 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013486 PGS002407
(disease_HYPERTENSION_DIAGNOSED.P+T.0.0001)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0185 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013535 PGS002407
(disease_HYPERTENSION_DIAGNOSED.P+T.0.0001)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.012 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013584 PGS002456
(disease_HYPERTENSION_DIAGNOSED.P+T.0.001)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013633 PGS002456
(disease_HYPERTENSION_DIAGNOSED.P+T.0.001)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0028 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013682 PGS002456
(disease_HYPERTENSION_DIAGNOSED.P+T.0.001)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0182 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013731 PGS002456
(disease_HYPERTENSION_DIAGNOSED.P+T.0.001)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0066 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013780 PGS002505
(disease_HYPERTENSION_DIAGNOSED.P+T.0.01)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013829 PGS002505
(disease_HYPERTENSION_DIAGNOSED.P+T.0.01)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013878 PGS002505
(disease_HYPERTENSION_DIAGNOSED.P+T.0.01)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0115 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013927 PGS002505
(disease_HYPERTENSION_DIAGNOSED.P+T.0.01)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0044 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013976 PGS002554
(disease_HYPERTENSION_DIAGNOSED.P+T.1e-06)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0034 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014025 PGS002554
(disease_HYPERTENSION_DIAGNOSED.P+T.1e-06)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0057 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014074 PGS002554
(disease_HYPERTENSION_DIAGNOSED.P+T.1e-06)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0128 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014123 PGS002554
(disease_HYPERTENSION_DIAGNOSED.P+T.1e-06)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0086 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014172 PGS002603
(disease_HYPERTENSION_DIAGNOSED.P+T.5e-08)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014221 PGS002603
(disease_HYPERTENSION_DIAGNOSED.P+T.5e-08)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014270 PGS002603
(disease_HYPERTENSION_DIAGNOSED.P+T.5e-08)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.011 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014319 PGS002603
(disease_HYPERTENSION_DIAGNOSED.P+T.5e-08)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.007 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014368 PGS002652
(disease_HYPERTENSION_DIAGNOSED.PolyFun-pred)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0195 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014417 PGS002652
(disease_HYPERTENSION_DIAGNOSED.PolyFun-pred)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0417 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014466 PGS002652
(disease_HYPERTENSION_DIAGNOSED.PolyFun-pred)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0539 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014515 PGS002652
(disease_HYPERTENSION_DIAGNOSED.PolyFun-pred)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0476 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014564 PGS002701
(disease_HYPERTENSION_DIAGNOSED.SBayesR)
PSS009783|
African Ancestry|
6,438 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0146 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014613 PGS002701
(disease_HYPERTENSION_DIAGNOSED.SBayesR)
PSS009784|
East Asian Ancestry|
913 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0335 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014662 PGS002701
(disease_HYPERTENSION_DIAGNOSED.SBayesR)
PSS009785|
European Ancestry|
43,392 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0506 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014711 PGS002701
(disease_HYPERTENSION_DIAGNOSED.SBayesR)
PSS009786|
South Asian Ancestry|
7,948 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hypertension Incremental R2 (full model vs. covariates alone): 0.0453 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014965 PGS002765
(SBP_prscs)
PSS009939|
European Ancestry|
39,444 individuals
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.57 [1.51, 1.62] age, sex, 10 PCs, technical covariates
PPM015873 PGS002994
(ExPRSweb_Hypertension_20002-1065_LASSOSUM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.638 [1.587, 1.691]
β: 0.494 (0.0162)
AUROC: 0.628 [0.62, 0.636] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015876 PGS002995
(ExPRSweb_Hypertension_20002-1065_PT_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.556 [1.507, 1.607]
β: 0.442 (0.0164)
AUROC: 0.612 [0.603, 0.62] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015874 PGS002996
(ExPRSweb_Hypertension_20002-1065_PLINK_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.55 [1.501, 1.6]
β: 0.438 (0.0164)
AUROC: 0.611 [0.602, 0.619] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015872 PGS002997
(ExPRSweb_Hypertension_20002-1065_DBSLMM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.338 [1.299, 1.379]
β: 0.291 (0.0153)
AUROC: 0.58 [0.572, 0.59] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015875 PGS002998
(ExPRSweb_Hypertension_20002-1065_PRSCS_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.67 [1.617, 1.725]
β: 0.513 (0.0165)
AUROC: 0.63 [0.622, 0.639] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015878 PGS002999
(ExPRSweb_Hypertension_20002-1072_LASSOSUM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.036 [1.006, 1.067]
β: 0.0358 (0.015)
AUROC: 0.508 [0.498, 0.516] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015881 PGS003000
(ExPRSweb_Hypertension_20002-1072_PT_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.034 [1.004, 1.065]
β: 0.0338 (0.015)
AUROC: 0.507 [0.498, 0.516] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015879 PGS003001
(ExPRSweb_Hypertension_20002-1072_PLINK_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.032 [1.002, 1.063]
β: 0.0318 (0.015)
AUROC: 0.507 [0.498, 0.516] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015877 PGS003002
(ExPRSweb_Hypertension_20002-1072_DBSLMM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.003 [0.974, 1.033]
β: 0.0026 (0.015)
AUROC: 0.486 [0.478, 0.495] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015880 PGS003003
(ExPRSweb_Hypertension_20002-1072_PRSCS_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.059 [1.029, 1.09]
β: 0.0573 (0.0149)
AUROC: 0.516 [0.507, 0.524] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015889 PGS003004
(ExPRSweb_Hypertension_finngen-R4-FG_LASSOSUM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.983 [0.955, 1.012]
β: -0.0172 (0.0149)
AUROC: 0.51 [0.5, 0.519] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015895 PGS003005
(ExPRSweb_Hypertension_finngen-R4-FG_PT_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.016 [0.986, 1.046]
β: 0.0155 (0.015)
AUROC: 0.506 [0.497, 0.515] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015891 PGS003006
(ExPRSweb_Hypertension_finngen-R4-FG_PLINK_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.987 [0.959, 1.017]
β: -0.0127 (0.015)
AUROC: 0.502 [0.492, 0.511] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015887 PGS003007
(ExPRSweb_Hypertension_finngen-R4-FG_DBSLMM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.015 [0.986, 1.045]
β: 0.0153 (0.0149)
AUROC: 0.498 [0.489, 0.507] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015893 PGS003008
(ExPRSweb_Hypertension_finngen-R4-FG_PRSCS_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.988 [0.959, 1.017]
β: -0.0122 (0.0149)
AUROC: 0.5 [0.49, 0.508] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015899 PGS003009
(ExPRSweb_Hypertension_finngen-R4-I9_LASSOSUM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.99 [0.961, 1.019]
β: -0.0105 (0.015)
AUROC: 0.512 [0.503, 0.521] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015905 PGS003010
(ExPRSweb_Hypertension_finngen-R4-I9_PT_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.023 [0.993, 1.053]
β: 0.0224 (0.015)
AUROC: 0.507 [0.498, 0.515] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015901 PGS003011
(ExPRSweb_Hypertension_finngen-R4-I9_PLINK_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.023 [0.993, 1.054]
β: 0.0229 (0.0151)
AUROC: 0.505 [0.496, 0.514] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015897 PGS003012
(ExPRSweb_Hypertension_finngen-R4-I9_DBSLMM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.019 [0.99, 1.05]
β: 0.0193 (0.0149)
AUROC: 0.502 [0.493, 0.511] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015903 PGS003013
(ExPRSweb_Hypertension_finngen-R4-I9_PRSCS_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.991 [0.962, 1.02]
β: -0.00951 (0.0149)
AUROC: 0.5 [0.491, 0.509] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015883 PGS003014
(ExPRSweb_Hypertension_I10_LASSOSUM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.065 [1.035, 1.097]
β: 0.0634 (0.015)
AUROC: 0.517 [0.509, 0.526] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015886 PGS003015
(ExPRSweb_Hypertension_I10_PT_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.07 [1.039, 1.102]
β: 0.0677 (0.015)
AUROC: 0.522 [0.513, 0.53] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015884 PGS003016
(ExPRSweb_Hypertension_I10_PLINK_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.066 [1.035, 1.098]
β: 0.064 (0.015)
AUROC: 0.521 [0.512, 0.53] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015882 PGS003017
(ExPRSweb_Hypertension_I10_DBSLMM_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.006 [0.977, 1.036]
β: 0.0057 (0.015)
AUROC: 0.492 [0.484, 0.502] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015885 PGS003018
(ExPRSweb_Hypertension_I10_PRSCS_MGI_20211120)
PSS010008|
European Ancestry|
23,316 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.07 [1.038, 1.102]
β: 0.0672 (0.015)
AUROC: 0.519 [0.51, 0.527] SEX,AGE,Batch,PC1,PC2,PC3,PC4
PPM015890 PGS003019
(ExPRSweb_Hypertension_finngen-R4-FG_LASSOSUM_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.016 [1.004, 1.027]
β: 0.0156 (0.00586)
AUROC: 0.505 [0.502, 0.509] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015896 PGS003020
(ExPRSweb_Hypertension_finngen-R4-FG_PT_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.992 [0.98, 1.003]
β: -0.00832 (0.00587)
AUROC: 0.506 [0.503, 0.509] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015892 PGS003021
(ExPRSweb_Hypertension_finngen-R4-FG_PLINK_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.01 [0.999, 1.022]
β: 0.0101 (0.00587)
AUROC: 0.503 [0.5, 0.507] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015888 PGS003022
(ExPRSweb_Hypertension_finngen-R4-FG_DBSLMM_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.002 [0.99, 1.013]
β: 0.0015 (0.00585)
AUROC: 0.491 [0.488, 0.494] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015894 PGS003023
(ExPRSweb_Hypertension_finngen-R4-FG_PRSCS_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.012 [1.001, 1.024]
β: 0.012 (0.00587)
AUROC: 0.506 [0.502, 0.509] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015900 PGS003024
(ExPRSweb_Hypertension_finngen-R4-I9_LASSOSUM_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.01 [0.998, 1.022]
β: 0.00982 (0.00587)
AUROC: 0.503 [0.5, 0.507] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015906 PGS003025
(ExPRSweb_Hypertension_finngen-R4-I9_PT_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 0.991 [0.98, 1.002]
β: -0.00913 (0.00587)
AUROC: 0.504 [0.501, 0.507] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015902 PGS003026
(ExPRSweb_Hypertension_finngen-R4-I9_PLINK_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.006 [0.994, 1.018]
β: 0.00592 (0.00587)
AUROC: 0.502 [0.498, 0.505] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015898 PGS003027
(ExPRSweb_Hypertension_finngen-R4-I9_DBSLMM_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.0 [0.989, 1.011]
β: -7e-05 (0.00584)
AUROC: 0.492 [0.489, 0.494] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4
PPM015904 PGS003028
(ExPRSweb_Hypertension_finngen-R4-I9_PRSCS_UKB_20211120)
PSS010030|
European Ancestry|
203,639 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Hypertension OR: 1.009 [0.997, 1.021]
β: 0.00888 (0.00587)
AUROC: 0.505 [0.502, 0.509] Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007757 2,484 individuals African American or Afro-Caribbean Carribean UKB
PSS004406
[
  • 2,406 cases
  • , 5,425 controls
]
South Asian UKB
PSS000822 87,413 individuals European UKB
PSS008412 1,200 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009310 20,000 individuals European UK (+ Ireland) UKB
PSS004711
[
  • 2,034 cases
  • , 4,463 controls
]
African unspecified UKB
PSS004712
[
  • 298 cases
  • , 1,406 controls
]
East Asian UKB
PSS004713
[
  • 5,400 cases
  • , 19,505 controls
]
European non-white British ancestry UKB
PSS004714
[
  • 2,513 cases
  • , 5,318 controls
]
South Asian UKB
PSS004715
[
  • 16,689 cases
  • , 50,736 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS009784 913 individuals East Asian UKB
PSS009783 6,438 individuals African unspecified UKB
PSS009785 43,392 individuals European Non-British European UKB
PSS009786 7,948 individuals South Asian UKB
PSS010008 PheCode 401.1 (http://phewascatalog.org/); Binary
[
  • 11,612 cases
  • , 11,704 controls
]
European MGI
PSS009084 4,136 individuals European Poland (NE Europe) UKB
PSS008192 6,331 individuals South Asian India (South Asia) UKB
PSS004349
[
  • 2,919 cases
  • , 3,578 controls
]
African unspecified UKB
PSS004350
[
  • 446 cases
  • , 1,258 controls
]
East Asian UKB
PSS004351
[
  • 7,648 cases
  • , 17,257 controls
]
European non-white British ancestry UKB
PSS004352
[
  • 3,161 cases
  • , 4,670 controls
]
South Asian UKB
PSS004353
[
  • 22,882 cases
  • , 44,543 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS010030 PheCode 401.1 (http://phewascatalog.org/); Binary
[
  • 38,801 cases
  • , 164,838 controls
]
European UKB
PSS009654
[
  • 1,284 cases
  • , 960 controls
]
,
61.0 % Male samples
European NR
PSS008861 3,924 individuals African unspecified Nigeria (West Africa) UKB
PSS009939 39,444 individuals European
(Finnish)
FinnGen
PSS007974 1,810 individuals East Asian China (East Asia) UKB
PSS004403
[
  • 1,956 cases
  • , 4,541 controls
]
African unspecified UKB
PSS004404
[
  • 259 cases
  • , 1,445 controls
]
East Asian UKB
PSS004405
[
  • 4,864 cases
  • , 20,041 controls
]
European non-white British ancestry UKB
PSS008638 6,660 individuals European Italy (South Europe) UKB
PSS004407
[
  • 15,118 cases
  • , 52,307 controls
]
European white British ancestry UKB Testing cohort (heldout set)