Trait: insulin resistance

Experimental Factor Ontology (EFO) Information
Identifier EFO_0002614
Description diminished effectiveness of insulin in lowering plasma glucose levels
Trait category
Other trait
Synonyms 2 synonyms
  • Drug resistance to insulin (disorder)
  • IR
Mapped terms 5 mapped terms
  • HP:0000855
  • MP:0005331
  • MeSH:D007333
  • MedDRA:10022489
  • NCIt:C113101

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000877
(uwGRS53_IR)
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Insulin resistance insulin resistance 53
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000877/ScoringFiles/PGS000877.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002512 PGS000877
(uwGRS53_IR)
PSS001134|
Ancestry Not Reported|
9,747 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Leg fat mass Beta (top 20% vs bottom 20%): -712.0 [-905.0, -519.0] Beta value = fat mass in grams
PPM002513 PGS000877
(uwGRS53_IR)
PSS001131|
European Ancestry|
16,687 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Incident type II diabetes Hazard Ratio (HR, top 20% vs. bottom 20%): 1.39 [1.25, 1.54]
PPM002514 PGS000877
(uwGRS53_IR)
PSS001133|
Ancestry Not Reported|
10,330 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Alanine aminotransferase levels β: 0.054 (0.009)
PPM002515 PGS000877
(uwGRS53_IR)
PSS001133|
Ancestry Not Reported|
10,330 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Gamma glutamyl transferase levels β: 0.054 (0.009)
PPM002508 PGS000877
(uwGRS53_IR)
PSS001129|
Ancestry Not Reported|
2,764 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Insulin sensitivity β: -0.09 (0.019)
PPM002509 PGS000877
(uwGRS53_IR)
PSS001130|
Ancestry Not Reported|
4,769 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Insulin sensitivity index β: -0.1 (0.016)
PPM002510 PGS000877
(uwGRS53_IR)
PSS001132|
Multi-ancestry (including European)|
276,194 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Type II diabetes OR: 1.12 [1.11, 1.14]
PPM002511 PGS000877
(uwGRS53_IR)
PSS001128|
Ancestry Not Reported|
194,427 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Coronary heart disease OR: 1.05 [1.04, 1.06]
PPM020263 PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Coronary artey disease Odds Ratio (OR, top 25% vs bottom 25%): 1.21 [1.03, 1.42]
PPM020264 PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Coronary artey disease Odds Ratio (OR, top 25% vs bottom 25%): 1.25 [1.06, 1.48] Gender, age, smoking status, hypertension
PPM020265 PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Three-vessel coronary artery disease Odds Ratio (OR, top 25% vs bottom 25%): 1.41 [1.1, 1.82] Gender, age, smoking status, hypertension
PPM020266 PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Three-vessel coronary artery disease Odds Ratio (OR, top 25% vs bottom 25%): 1.36 [1.06, 1.47]

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001128 Cases were individuals with coronary heart disease
[
  • 63,746 cases
  • , 130,681 controls
]
Not reported CARDIoGRAMplusC4D
PSS001129 All individuals had insulin sensitivity measured by euglycemic clamp or insulin suppression. 2,764 individuals Not reported GENESIS
PSS001130 All individuals had insulin sensitivity index calculated via frequently sampled oral glucose tolerance tests. 4,769 individuals Not reported MAGIC
PSS001131 Cases were individuals that developed type II diabetes Mean = 8.0 years
[
  • 7,420 cases
  • , 9,267 controls
]
European InterAct
PSS001132 Cases were individuals with type II diabetes
[
  • 45,836 cases
  • , 230,358 controls
]
European, NR European, NR DIAGRAM, InterAct, UKB
PSS001133 Individuals were used to calculate alanine aminotransferase and gamma glutamyl transferase levels 10,330 individuals Not reported Fenland
PSS001134 Individuals were used to calculate leg fat mass using dual-energy X-ray absorptiometry. 9,747 individuals Not reported Fenland
PSS011314 Cases are individuals with significant coronary artery disease. Of the 2,725 individuals with coronary artery disease, 1,345 were defined as having one-vessel, 705 were defined as having two-vessel and 675 were defined as having three-vessel coronary artey disease.
[
  • 2,725 cases
  • , 2,238 controls
]
,
64.7 % Male samples
Mean = 65.2 years
Sd = 11.3 years
European COGEN