Trait: nicotine dependence

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003768
Description Physical and psychological dependence on nicotine. [NCIT: P378]
Trait category
Neurological disorder
Synonyms 28 synonyms
  • Cigarette Smoking
  • Dependence, Nicotine
  • Dependence, Tobacco
  • Disorder, Nicotine Use
  • Disorder, Tobacco Use
  • Disorder, Tobacco-Use
  • NICOTINE USE DIS
  • Nicotine Addiction
  • Nicotine Use Disorder
  • Nicotine Use Disorders
  • Smoking, Cigarette
  • Smoking, Tobacco
  • Smokings, Tobacco
  • TOBACCO USE DIS
  • Tobacco Dependence
  • Tobacco Dependences
  • Tobacco Smoking
  • Tobacco Smokings
  • Tobacco Use Disorder
  • Tobacco Use Disorders
  • Tobacco-Use Disorder
  • Use Disorder, Nicotine
  • nicotine addiction
  • nicotine addiction, protection from
  • nicotine dependence
  • nicotine dependence, protection against
  • smoking
  • tobacco use disorder
Mapped terms 14 mapped terms
  • DOID:0050742
  • ICD10:F17
  • ICD10CM:F17
  • ICD9:305.1
  • MESH:D014029
  • MONDO:0008575
  • MeSH:D012907
  • MeSH:D014029
  • MedDRA:10057852
  • NCIT:C54203
  • NCIt:C54203
  • OMIM:188890
  • SCTID:56294008
  • SNOMEDCT:56294008

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001830
(portability-PLR_318)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Tobacco use disorder nicotine dependence 13,838
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001830/ScoringFiles/PGS001830.txt.gz
PGS002037
(portability-ldpred2_318)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Tobacco use disorder nicotine dependence 847,691
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002037/ScoringFiles/PGS002037.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009533 PGS001830
(portability-PLR_318)
PSS009300|
European Ancestry|
19,400 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0557 [0.0416, 0.0697] sex, age, birth date, deprivation index, 16 PCs
PPM009534 PGS001830
(portability-PLR_318)
PSS009074|
European Ancestry|
4,022 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0092 [-0.0218, 0.0401] sex, age, birth date, deprivation index, 16 PCs
PPM009535 PGS001830
(portability-PLR_318)
PSS008628|
European Ancestry|
6,548 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0603 [0.0361, 0.0845] sex, age, birth date, deprivation index, 16 PCs
PPM009536 PGS001830
(portability-PLR_318)
PSS008402|
Greater Middle Eastern Ancestry|
1,180 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0076 [-0.05, 0.0651] sex, age, birth date, deprivation index, 16 PCs
PPM009537 PGS001830
(portability-PLR_318)
PSS008182|
South Asian Ancestry|
6,249 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0361 [0.0113, 0.0609] sex, age, birth date, deprivation index, 16 PCs
PPM009538 PGS001830
(portability-PLR_318)
PSS007967|
East Asian Ancestry|
1,800 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0404 [-0.0061, 0.0867] sex, age, birth date, deprivation index, 16 PCs
PPM009539 PGS001830
(portability-PLR_318)
PSS007748|
African Ancestry|
2,445 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): -0.0084 [-0.0482, 0.0314] sex, age, birth date, deprivation index, 16 PCs
PPM009540 PGS001830
(portability-PLR_318)
PSS008852|
African Ancestry|
3,876 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0032 [-0.0284, 0.0347] sex, age, birth date, deprivation index, 16 PCs
PPM011163 PGS002037
(portability-ldpred2_318)
PSS009300|
European Ancestry|
19,400 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0741 [0.0601, 0.0881] sex, age, birth date, deprivation index, 16 PCs
PPM011164 PGS002037
(portability-ldpred2_318)
PSS009074|
European Ancestry|
4,022 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0253 [-0.0056, 0.0563] sex, age, birth date, deprivation index, 16 PCs
PPM011166 PGS002037
(portability-ldpred2_318)
PSS008402|
Greater Middle Eastern Ancestry|
1,180 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.043 [-0.0146, 0.1003] sex, age, birth date, deprivation index, 16 PCs
PPM011167 PGS002037
(portability-ldpred2_318)
PSS008182|
South Asian Ancestry|
6,249 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0598 [0.035, 0.0845] sex, age, birth date, deprivation index, 16 PCs
PPM011168 PGS002037
(portability-ldpred2_318)
PSS007967|
East Asian Ancestry|
1,800 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0244 [-0.0221, 0.0708] sex, age, birth date, deprivation index, 16 PCs
PPM011169 PGS002037
(portability-ldpred2_318)
PSS007748|
African Ancestry|
2,445 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0244 [-0.0154, 0.0642] sex, age, birth date, deprivation index, 16 PCs
PPM011170 PGS002037
(portability-ldpred2_318)
PSS008852|
African Ancestry|
3,876 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): -0.0199 [-0.0514, 0.0117] sex, age, birth date, deprivation index, 16 PCs
PPM011165 PGS002037
(portability-ldpred2_318)
PSS008628|
European Ancestry|
6,548 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Tobacco use disorder Partial Correlation (partial-r): 0.0812 [0.0571, 0.1053] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007748 2,445 individuals African American or Afro-Caribbean Carribean UKB
PSS008402 1,180 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009074 4,022 individuals European Poland (NE Europe) UKB
PSS009300 19,400 individuals European UK (+ Ireland) UKB
PSS008628 6,548 individuals European Italy (South Europe) UKB
PSS008182 6,249 individuals South Asian India (South Asia) UKB
PSS008852 3,876 individuals African unspecified Nigeria (West Africa) UKB
PSS007967 1,800 individuals East Asian China (East Asia) UKB