Trait: sex hormone-binding globulin

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003941
  • A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Trait category
Other trait
Synonyms 11 synonyms
  • Binding Globulin, Testosterone-Estradiol
  • Globulin, Sex Hormone-Binding
  • Globulin, Testosterone-Estradiol Binding
  • Hormone-Binding Globulin, Sex
  • SHBG
  • Sex Hormone Binding Globulin
  • Sex Steroid Binding Protein
  • Sex Steroid-Binding Protein
  • Steroid-Binding Protein, Sex
  • Testosterone Estradiol Binding Globulin
  • Testosterone-Estradiol Binding Globulin
Mapped terms 2 mapped terms
  • MeSH:D012738
  • NCIt:C17128

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
East Asian
South Asian
Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000561 |
Jung H et al. Commun Biol (2024)
SHBG (nmol/L) sex hormone-binding globulin 1,059,939

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020455 PGS004340
European Ancestry|
56,192 individuals
PGP000561 |
Jung H et al. Commun Biol (2024)
Reported Trait: SHBG (nmol/L) PGS R2 (no covariates): 0.26166

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011364 56,192 individuals European UKB