Trait: vital capacity

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004312
Description The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Trait category
Other measurement
Synonyms 2 synonyms
  • FVC
  • forced vital capacity
Mapped terms 4 mapped terms
  • MeSH:D014797
  • MedDRA:10047579
  • NCIt:C111361
  • SNOMEDCT:268379003

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001237
(GBE_INI3062)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Lung function (FVC) vital capacity 20,921
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001237/ScoringFiles/PGS001237.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008694 PGS001237
(GBE_INI3062)
PSS007081|
African Ancestry|
5,865 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FVC : 0.38605 [0.3675, 0.40459]
Incremental R2 (full-covars): -0.00854
PGS R2 (no covariates): 0.00449 [0.00125, 0.00774]
age, sex, UKB array type, Genotype PCs
PPM008695 PGS001237
(GBE_INI3062)
PSS007082|
East Asian Ancestry|
1,590 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FVC : 0.48915 [0.45529, 0.52301]
Incremental R2 (full-covars): 0.0239
PGS R2 (no covariates): 0.03634 [0.01893, 0.05375]
age, sex, UKB array type, Genotype PCs
PPM008696 PGS001237
(GBE_INI3062)
PSS007083|
European Ancestry|
22,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FVC : 0.53532 [0.52687, 0.54376]
Incremental R2 (full-covars): 0.04669
PGS R2 (no covariates): 0.04902 [0.04379, 0.05425]
age, sex, UKB array type, Genotype PCs
PPM008697 PGS001237
(GBE_INI3062)
PSS007084|
South Asian Ancestry|
7,147 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FVC : 0.42603 [0.40944, 0.44262]
Incremental R2 (full-covars): 0.00884
PGS R2 (no covariates): 0.02153 [0.01517, 0.02789]
age, sex, UKB array type, Genotype PCs
PPM008698 PGS001237
(GBE_INI3062)
PSS007085|
European Ancestry|
62,090 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FVC : 0.51644 [0.5112, 0.52169]
Incremental R2 (full-covars): 0.04662
PGS R2 (no covariates): 0.04936 [0.04617, 0.05255]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007081 5,865 individuals African unspecified UKB
PSS007082 1,590 individuals East Asian UKB
PSS007083 22,831 individuals European non-white British ancestry UKB
PSS007084 7,147 individuals South Asian UKB
PSS007085 62,090 individuals European white British ancestry UKB Testing cohort (heldout set)