Trait: vital capacity

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004312
Description The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Trait category
Other measurement
Synonyms 2 synonyms
  • FVC
  • forced vital capacity
Mapped terms 4 mapped terms
  • MeSH:D014797
  • MedDRA:10047579
  • NCIt:C111361
  • SNOMEDCT:268379003

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001237
(GBE_INI3062)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Lung function (FVC) vital capacity 20,921
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001237/ScoringFiles/PGS001237.txt.gz
PGS001922
(portability-PLR_FVC)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Forced vital capacity (FVC), Best measure vital capacity 85,349
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001922/ScoringFiles/PGS001922.txt.gz
PGS002138
(portability-ldpred2_FVC)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Forced vital capacity (FVC), Best measure vital capacity 940,300
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002138/ScoringFiles/PGS002138.txt.gz
PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002327/ScoringFiles/PGS002327.txt.gz
PGS002399
(lung_FVCzSMOKE.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 9,469
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002399/ScoringFiles/PGS002399.txt.gz
PGS002448
(lung_FVCzSMOKE.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 29,603
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002448/ScoringFiles/PGS002448.txt.gz
PGS002497
(lung_FVCzSMOKE.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 134,519
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002497/ScoringFiles/PGS002497.txt.gz
PGS002546
(lung_FVCzSMOKE.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 2,327
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002546/ScoringFiles/PGS002546.txt.gz
PGS002595
(lung_FVCzSMOKE.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 1,235
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002595/ScoringFiles/PGS002595.txt.gz
PGS002644
(lung_FVCzSMOKE.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 592,696
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002644/ScoringFiles/PGS002644.txt.gz
PGS002693
(lung_FVCzSMOKE.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Forced Vital Capacity vital capacity 986,815
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002693/ScoringFiles/PGS002693.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008694 PGS001237
(GBE_INI3062)
PSS007081|
African Ancestry|
5,865 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC : 0.38605 [0.3675, 0.40459]
Incremental R2 (full-covars): -0.00854
PGS R2 (no covariates): 0.00449 [0.00125, 0.00774]
age, sex, UKB array type, Genotype PCs
PPM008695 PGS001237
(GBE_INI3062)
PSS007082|
East Asian Ancestry|
1,590 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC : 0.48915 [0.45529, 0.52301]
Incremental R2 (full-covars): 0.0239
PGS R2 (no covariates): 0.03634 [0.01893, 0.05375]
age, sex, UKB array type, Genotype PCs
PPM008696 PGS001237
(GBE_INI3062)
PSS007083|
European Ancestry|
22,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC : 0.53532 [0.52687, 0.54376]
Incremental R2 (full-covars): 0.04669
PGS R2 (no covariates): 0.04902 [0.04379, 0.05425]
age, sex, UKB array type, Genotype PCs
PPM008697 PGS001237
(GBE_INI3062)
PSS007084|
South Asian Ancestry|
7,147 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC : 0.42603 [0.40944, 0.44262]
Incremental R2 (full-covars): 0.00884
PGS R2 (no covariates): 0.02153 [0.01517, 0.02789]
age, sex, UKB array type, Genotype PCs
PPM008698 PGS001237
(GBE_INI3062)
PSS007085|
European Ancestry|
62,090 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FVC : 0.51644 [0.5112, 0.52169]
Incremental R2 (full-covars): 0.04662
PGS R2 (no covariates): 0.04936 [0.04617, 0.05255]
age, sex, UKB array type, Genotype PCs
PPM010255 PGS001922
(portability-PLR_FVC)
PSS009370|
European Ancestry|
15,118 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.3635 [0.3496, 0.3773] sex, age, birth date, deprivation index, 16 PCs
PPM010257 PGS001922
(portability-PLR_FVC)
PSS008698|
European Ancestry|
4,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.3258 [0.2995, 0.3517] sex, age, birth date, deprivation index, 16 PCs
PPM010258 PGS001922
(portability-PLR_FVC)
PSS008472|
Greater Middle Eastern Ancestry|
163 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.307 [0.1505, 0.4486] sex, age, birth date, deprivation index, 16 PCs
PPM010256 PGS001922
(portability-PLR_FVC)
PSS009144|
European Ancestry|
2,907 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.346 [0.3135, 0.3777] sex, age, birth date, deprivation index, 16 PCs
PPM011955 PGS002138
(portability-ldpred2_FVC)
PSS009370|
European Ancestry|
15,118 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.3604 [0.3464, 0.3742] sex, age, birth date, deprivation index, 16 PCs
PPM011956 PGS002138
(portability-ldpred2_FVC)
PSS009144|
European Ancestry|
2,907 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.3369 [0.3042, 0.3689] sex, age, birth date, deprivation index, 16 PCs
PPM011957 PGS002138
(portability-ldpred2_FVC)
PSS008698|
European Ancestry|
4,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.3329 [0.3066, 0.3586] sex, age, birth date, deprivation index, 16 PCs
PPM011958 PGS002138
(portability-ldpred2_FVC)
PSS008472|
Greater Middle Eastern Ancestry|
163 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Forced vital capacity (FVC), Best measure Partial Correlation (partial-r): 0.3085 [0.1521, 0.4499] sex, age, birth date, deprivation index, 16 PCs
PPM013190 PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.1004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013092 PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0293 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013141 PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0397 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013239 PGS002327
(lung_FVCzSMOKE.BOLT-LMM)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0676 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013380 PGS002399
(lung_FVCzSMOKE.P+T.0.0001)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013429 PGS002399
(lung_FVCzSMOKE.P+T.0.0001)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0043 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013478 PGS002399
(lung_FVCzSMOKE.P+T.0.0001)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0424 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013527 PGS002399
(lung_FVCzSMOKE.P+T.0.0001)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0256 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013576 PGS002448
(lung_FVCzSMOKE.P+T.0.001)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013674 PGS002448
(lung_FVCzSMOKE.P+T.0.001)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0381 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013723 PGS002448
(lung_FVCzSMOKE.P+T.0.001)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0045 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013625 PGS002448
(lung_FVCzSMOKE.P+T.0.001)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0052 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013772 PGS002497
(lung_FVCzSMOKE.P+T.0.01)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013821 PGS002497
(lung_FVCzSMOKE.P+T.0.01)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013919 PGS002497
(lung_FVCzSMOKE.P+T.0.01)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0025 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013870 PGS002497
(lung_FVCzSMOKE.P+T.0.01)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0295 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013968 PGS002546
(lung_FVCzSMOKE.P+T.1e-06)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014017 PGS002546
(lung_FVCzSMOKE.P+T.1e-06)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0154 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014066 PGS002546
(lung_FVCzSMOKE.P+T.1e-06)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0241 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014115 PGS002546
(lung_FVCzSMOKE.P+T.1e-06)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0168 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014164 PGS002595
(lung_FVCzSMOKE.P+T.5e-08)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0051 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014213 PGS002595
(lung_FVCzSMOKE.P+T.5e-08)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0052 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014262 PGS002595
(lung_FVCzSMOKE.P+T.5e-08)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0168 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014311 PGS002595
(lung_FVCzSMOKE.P+T.5e-08)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0107 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014360 PGS002644
(lung_FVCzSMOKE.PolyFun-pred)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0296 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014409 PGS002644
(lung_FVCzSMOKE.PolyFun-pred)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0531 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014458 PGS002644
(lung_FVCzSMOKE.PolyFun-pred)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1044 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014507 PGS002644
(lung_FVCzSMOKE.PolyFun-pred)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0707 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014556 PGS002693
(lung_FVCzSMOKE.SBayesR)
PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0276 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014605 PGS002693
(lung_FVCzSMOKE.SBayesR)
PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0474 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014654 PGS002693
(lung_FVCzSMOKE.SBayesR)
PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0952 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014703 PGS002693
(lung_FVCzSMOKE.SBayesR)
PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0658 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009751 4,243 individuals African unspecified UKB
PSS009752 679 individuals East Asian UKB
PSS007081 5,865 individuals African unspecified UKB
PSS007082 1,590 individuals East Asian UKB
PSS007083 22,831 individuals European non-white British ancestry UKB
PSS007084 7,147 individuals South Asian UKB
PSS007085 62,090 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009753 34,753 individuals European Non-British European UKB
PSS009754 5,538 individuals South Asian UKB
PSS008472 163 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009144 2,907 individuals European Poland (NE Europe) UKB
PSS009370 15,118 individuals European UK (+ Ireland) UKB
PSS008698 4,520 individuals European Italy (South Europe) UKB