Trait: forced expiratory volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004314
Description Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Trait category
Other measurement
Synonyms 3 synonyms
  • FEV1
  • FEVt
  • timed vital capacity
Mapped terms 3 mapped terms
  • MeSH:D005541
  • MedDRA:10016984
  • NCIt:C120933

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001236
(GBE_INI3063)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Lung function (FEV1) forced expiratory volume 17,732
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001236/ScoringFiles/PGS001236.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008689 PGS001236
(GBE_INI3063)
PSS007091|
African Ancestry|
5,865 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FEV1 : 0.37563 [0.35703, 0.39423]
Incremental R2 (full-covars): -0.00395
PGS R2 (no covariates): 0.00371 [0.00076, 0.00666]
age, sex, UKB array type, Genotype PCs
PPM008690 PGS001236
(GBE_INI3063)
PSS007092|
East Asian Ancestry|
1,590 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FEV1 : 0.48044 [0.44632, 0.51457]
Incremental R2 (full-covars): 0.01654
PGS R2 (no covariates): 0.03258 [0.01603, 0.04912]
age, sex, UKB array type, Genotype PCs
PPM008691 PGS001236
(GBE_INI3063)
PSS007093|
European Ancestry|
22,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FEV1 : 0.5167 [0.50807, 0.52533]
Incremental R2 (full-covars): 0.0401
PGS R2 (no covariates): 0.04225 [0.03736, 0.04714]
age, sex, UKB array type, Genotype PCs
PPM008692 PGS001236
(GBE_INI3063)
PSS007094|
South Asian Ancestry|
7,147 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FEV1 : 0.46546 [0.44931, 0.4816]
Incremental R2 (full-covars): 0.01517
PGS R2 (no covariates): 0.0239 [0.01722, 0.03059]
age, sex, UKB array type, Genotype PCs
PPM008693 PGS001236
(GBE_INI3063)
PSS007095|
European Ancestry|
62,090 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: FEV1 : 0.51484 [0.50958, 0.52009]
Incremental R2 (full-covars): 0.04356
PGS R2 (no covariates): 0.04413 [0.0411, 0.04716]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007091 5,865 individuals African unspecified UKB
PSS007092 1,590 individuals East Asian UKB
PSS007093 22,831 individuals European non-white British ancestry UKB
PSS007094 7,147 individuals South Asian UKB
PSS007095 62,090 individuals European white British ancestry UKB Testing cohort (heldout set)