Trait: body height

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004339
Description The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.
Trait category
Body measurement
Synonym height
Mapped terms 3 mapped terms
  • MeSH:D001827
  • MedDRA:10005891
  • NCIt:C25347

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000297
(GRS3290_Height)
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Height body height 3,290
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000297/ScoringFiles/PGS000297.txt.gz
PGS000758
(LASSO_Height)
PGP000163 |
Lu T et al. J Clin Endocrinol Metab (2021)
Adult standing height body height 33,938
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000758/ScoringFiles/PGS000758.txt.gz - Check Terms/Licenses
PGS001229
(GBE_INI50)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Standing height body height 51,209
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001229/ScoringFiles/PGS001229.txt.gz
PGS001405
(GBE_INI12144)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Height body height 3,166
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001405/ScoringFiles/PGS001405.txt.gz
PGS001929
(portability-PLR_height)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Standing height body height 156,514
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001929/ScoringFiles/PGS001929.txt.gz
PGS002146
(portability-ldpred2_height)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Standing height body height 922,538
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002146/ScoringFiles/PGS002146.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000757 PGS000297
(GRS3290_Height)
PSS000375|
European Ancestry|
1,313 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.1172 Sex, age
PPM000758 PGS000297
(GRS3290_Height)
PSS000376|
European Ancestry|
1,354 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.1368 Sex, age
PPM000759 PGS000297
(GRS3290_Height)
PSS000377|
European Ancestry|
1,174 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.1273 Sex, age
PPM000760 PGS000297
(GRS3290_Height)
PSS000378|
European Ancestry|
1,095 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.1382 Sex, age
PPM000756 PGS000297
(GRS3290_Height)
PSS000374|
European Ancestry|
1,318 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.1192 Sex, age
PPM000786 PGS000297
(GRS3290_Height)
PSS000369|
European Ancestry|
334 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.087 Sex, age
PPM000787 PGS000297
(GRS3290_Height)
PSS000370|
European Ancestry|
329 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.0755 Sex, age
PPM000788 PGS000297
(GRS3290_Height)
PSS000371|
European Ancestry|
288 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.0887 Sex, age
PPM000789 PGS000297
(GRS3290_Height)
PSS000372|
European Ancestry|
265 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.0986 Sex, age
PPM000790 PGS000297
(GRS3290_Height)
PSS000373|
European Ancestry|
245 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Height (cm) : 0.1158 Sex, age
PPM001768 PGS000297
(GRS3290_Height)
PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Height Pearson correlation coefficent (r): 0.15
PPM001931 PGS000758
(LASSO_Height)
PSS000967|
European Ancestry|
941 individuals
PGP000163 |
Lu T et al. J Clin Endocrinol Metab (2021)
Reported Trait: Short stature in adulthood AUROC: 0.843 [0.796, 0.89] Area under the precision-recall curve (AUPRC): 0.284 [0.102, 0.5] Sex 33,783 SNPs were utilised from the 33,938 SNP score.
PPM001932 PGS000758
(LASSO_Height)
PSS000967|
European Ancestry|
941 individuals
PGP000163 |
Lu T et al. J Clin Endocrinol Metab (2021)
Reported Trait: Short stature in adulthood (females) OR: 0.62 [0.5, 0.75] AUROC: 0.861 [0.814, 0.907] Area under the precision-recall curve (AUPRC): 0.373 [0.087, 0.651] 33,783 SNPs were utilised from the 33,938 SNP score.
PPM001930 PGS000758
(LASSO_Height)
PSS000967|
European Ancestry|
941 individuals
PGP000163 |
Lu T et al. J Clin Endocrinol Metab (2021)
Reported Trait: Standing height in adulthood : 0.71 [0.679, 0.741] Sex 33,783 SNPs were utilised from the 33,938 SNP score.
PPM001933 PGS000758
(LASSO_Height)
PSS000967|
European Ancestry|
941 individuals
PGP000163 |
Lu T et al. J Clin Endocrinol Metab (2021)
Reported Trait: Short stature in adulthood (males) OR: 0.7 [0.57, 0.83] AUROC: 0.82 [0.731, 0.909] Area under the precision-recall curve (AUPRC): 0.181 [0.044, 0.518] 33,783 SNPs were utilised from the 33,938 SNP score.
PPM001929 PGS000758
(LASSO_Height)
PSS000969|
European Ancestry|
81,902 individuals
PGP000163 |
Lu T et al. J Clin Endocrinol Metab (2021)
Reported Trait: Standing height in adulthood : 0.711 [0.708, 0.714] Age, sex, recruitment center, genotyping array, PCs(1-20)
PPM008659 PGS001229
(GBE_INI50)
PSS007396|
African Ancestry|
6,407 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Standing height : 0.50012 [0.48294, 0.5173]
Incremental R2 (full-covars): 0.02391
PGS R2 (no covariates): 0.03665 [0.02769, 0.04561]
age, sex, UKB array type, Genotype PCs
PPM008660 PGS001229
(GBE_INI50)
PSS007397|
East Asian Ancestry|
1,697 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Standing height : 0.60758 [0.5786, 0.63657]
Incremental R2 (full-covars): 0.06552
PGS R2 (no covariates): 0.09127 [0.06525, 0.11728]
age, sex, UKB array type, Genotype PCs
PPM008661 PGS001229
(GBE_INI50)
PSS007398|
European Ancestry|
24,826 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Standing height : 0.7018 [0.69559, 0.708]
Incremental R2 (full-covars): 0.16478
PGS R2 (no covariates): 0.1861 [0.17738, 0.19482]
age, sex, UKB array type, Genotype PCs
PPM008662 PGS001229
(GBE_INI50)
PSS007399|
South Asian Ancestry|
7,650 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Standing height : 0.66523 [0.65314, 0.67732]
Incremental R2 (full-covars): 0.08156
PGS R2 (no covariates): 0.08889 [0.07686, 0.10092]
age, sex, UKB array type, Genotype PCs
PPM008663 PGS001229
(GBE_INI50)
PSS007400|
European Ancestry|
67,298 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Standing height : 0.71726 [0.71364, 0.72087]
Incremental R2 (full-covars): 0.17893
PGS R2 (no covariates): 0.17757 [0.17234, 0.1828]
age, sex, UKB array type, Genotype PCs
PPM005231 PGS001405
(GBE_INI12144)
PSS004802|
East Asian Ancestry|
133 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Height : 0.509 [0.47581, 0.5422]
Incremental R2 (full-covars): 0.00258
PGS R2 (no covariates): 0.00401 [-0.00197, 0.00998]
age, sex, UKB array type, Genotype PCs
PPM005230 PGS001405
(GBE_INI12144)
PSS004801|
African Ancestry|
253 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Height : 0.58747 [0.5721, 0.60284]
Incremental R2 (full-covars): 0.01915
PGS R2 (no covariates): 0.00938 [0.00471, 0.01404]
age, sex, UKB array type, Genotype PCs
PPM005232 PGS001405
(GBE_INI12144)
PSS004803|
European Ancestry|
2,131 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Height : 0.59354 [0.58576, 0.60132]
Incremental R2 (full-covars): 0.04611
PGS R2 (no covariates): 0.05219 [0.04681, 0.05757]
age, sex, UKB array type, Genotype PCs
PPM005233 PGS001405
(GBE_INI12144)
PSS004804|
South Asian Ancestry|
414 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Height : 0.56418 [0.54969, 0.57868]
Incremental R2 (full-covars): 0.03739
PGS R2 (no covariates): 0.02079 [0.01454, 0.02704]
age, sex, UKB array type, Genotype PCs
PPM005234 PGS001405
(GBE_INI12144)
PSS004805|
European Ancestry|
6,641 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Height : 0.59871 [0.59403, 0.6034]
Incremental R2 (full-covars): 0.05016
PGS R2 (no covariates): 0.05141 [0.04816, 0.05466]
age, sex, UKB array type, Genotype PCs
PPM010307 PGS001929
(portability-PLR_height)
PSS009416|
European Ancestry|
19,953 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.6344 [0.626, 0.6426] sex, age, birth date, deprivation index, 16 PCs
PPM010308 PGS001929
(portability-PLR_height)
PSS009190|
European Ancestry|
4,126 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.6098 [0.5902, 0.6286] sex, age, birth date, deprivation index, 16 PCs
PPM010310 PGS001929
(portability-PLR_height)
PSS008518|
Greater Middle Eastern Ancestry|
1,180 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.5167 [0.4732, 0.5576] sex, age, birth date, deprivation index, 16 PCs
PPM010311 PGS001929
(portability-PLR_height)
PSS008296|
South Asian Ancestry|
6,152 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.4923 [0.4731, 0.511] sex, age, birth date, deprivation index, 16 PCs
PPM010312 PGS001929
(portability-PLR_height)
PSS008073|
East Asian Ancestry|
1,801 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.4504 [0.4125, 0.4866] sex, age, birth date, deprivation index, 16 PCs
PPM010313 PGS001929
(portability-PLR_height)
PSS007860|
African Ancestry|
2,450 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.3454 [0.3099, 0.3799] sex, age, birth date, deprivation index, 16 PCs
PPM010314 PGS001929
(portability-PLR_height)
PSS008964|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.2731 [0.2436, 0.3021] sex, age, birth date, deprivation index, 16 PCs
PPM010309 PGS001929
(portability-PLR_height)
PSS008744|
European Ancestry|
6,633 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.5938 [0.578, 0.6092] sex, age, birth date, deprivation index, 16 PCs
PPM012015 PGS002146
(portability-ldpred2_height)
PSS009416|
European Ancestry|
19,953 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.6133 [0.6046, 0.6219] sex, age, birth date, deprivation index, 16 PCs
PPM012016 PGS002146
(portability-ldpred2_height)
PSS009190|
European Ancestry|
4,126 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.5922 [0.5719, 0.6117] sex, age, birth date, deprivation index, 16 PCs
PPM012017 PGS002146
(portability-ldpred2_height)
PSS008744|
European Ancestry|
6,633 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.5752 [0.5589, 0.5911] sex, age, birth date, deprivation index, 16 PCs
PPM012018 PGS002146
(portability-ldpred2_height)
PSS008518|
Greater Middle Eastern Ancestry|
1,180 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.4948 [0.4501, 0.5371] sex, age, birth date, deprivation index, 16 PCs
PPM012019 PGS002146
(portability-ldpred2_height)
PSS008296|
South Asian Ancestry|
6,152 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.4752 [0.4556, 0.4943] sex, age, birth date, deprivation index, 16 PCs
PPM012020 PGS002146
(portability-ldpred2_height)
PSS008073|
East Asian Ancestry|
1,801 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.4297 [0.3911, 0.4668] sex, age, birth date, deprivation index, 16 PCs
PPM012021 PGS002146
(portability-ldpred2_height)
PSS007860|
African Ancestry|
2,450 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.3207 [0.2846, 0.356] sex, age, birth date, deprivation index, 16 PCs
PPM012022 PGS002146
(portability-ldpred2_height)
PSS008964|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Standing height Partial Correlation (partial-r): 0.2554 [0.2256, 0.2847] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008518 1,180 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009416 19,953 individuals European UK (+ Ireland) UKB
PSS004801 253 individuals African unspecified UKB
PSS004802 133 individuals East Asian UKB
PSS004803 2,131 individuals European non-white British ancestry UKB
PSS004804 414 individuals South Asian UKB
PSS004805 6,641 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009190 4,126 individuals European Poland (NE Europe) UKB
PSS008296 6,152 individuals South Asian India (South Asia) UKB
PSS007396 6,407 individuals African unspecified UKB
PSS007397 1,697 individuals East Asian UKB
PSS007398 24,826 individuals European non-white British ancestry UKB
PSS007399 7,650 individuals South Asian UKB
PSS007400 67,298 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS000369 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 334 individuals,
69.2 % Male samples
Mean = 11.1 years
Sd = 0.48 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000370 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 329 individuals,
69.2 % Male samples
Mean = 12.81 years
Sd = 0.59 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000371 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 288 individuals,
69.2 % Male samples
Mean = 15.83 years
Sd = 0.6 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000372 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 265 individuals,
69.2 % Male samples
Mean = 19.2 years
Sd = 0.66 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000373 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 245 individuals,
69.2 % Male samples
Mean = 22.04 years
Sd = 0.69 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000374 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,318 individuals,
47.6 % Male samples
Mean = 11.1 years European TRAILS
PSS000375 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,313 individuals,
47.6 % Male samples
Mean = 13.5 years European TRAILS
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years
European TRAILS
PSS000377 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,174 individuals,
47.6 % Male samples
Mean = 19.2 years European TRAILS
PSS000378 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,095 individuals,
47.6 % Male samples
Mean = 22.4 years European TRAILS
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB
PSS000967
[
  • 21 cases
  • , 920 controls
]
,
42.5 % Male samples
European ALSPAC
PSS000969 81,902 individuals,
45.9 % Male samples
European UKB This dataset is independent of UKB source/training and model selection datasets
PSS008964 3,863 individuals African unspecified Nigeria (West Africa) UKB
PSS008073 1,801 individuals East Asian China (East Asia) UKB
PSS008744 6,633 individuals European Italy (South Europe) UKB
PSS007860 2,450 individuals African American or Afro-Caribbean Carribean UKB