Trait: C-reactive protein measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004458
Description C-reactive protein (CRP) measurement is a measurement of the level of C-reactive protein in the blood. Levels are known to rise in response to inflammation, CRP is therefore used as a clinical measure of inflammation. The measurement is used in the process of clinical diagnosis as high levels of CRP are associated with cardiovascular disease, diabetes and hypertension and in some cancers.
Trait category
Inflammatory measurement
Synonym C-reactive protein level
Mapped terms 2 mapped terms
  • NCIt:C64548
  • SNOMEDCT:55235003

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000314
(GRS77_CRP)
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
C-reactive protein C-reactive protein measurement 77
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000314/ScoringFiles/PGS000314.txt.gz
PGS000675
(snpnet.C_reactive_protein)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
C-reactive protein [mg/L] C-reactive protein measurement 17,378
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000675/ScoringFiles/PGS000675.txt.gz - Check Terms/Licenses
PGS001946
(portability-PLR_log_CRP)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
C-reactive protein C-reactive protein measurement 71,444
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001946/ScoringFiles/PGS001946.txt.gz
PGS002164
(portability-ldpred2_log_CRP)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
C-reactive protein C-reactive protein measurement 736,345
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002164/ScoringFiles/PGS002164.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000784 PGS000314
(GRS77_CRP)
PSS000376|
European Ancestry|
1,354 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: C-reactive protein (mg/l) : 0.0369 Sex, age
PPM001438 PGS000675
(snpnet.C_reactive_protein)
PSS000653|
East Asian Ancestry|
1,077 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: C-reactive protein [mg/L] : 0.10659
Spearman's ρ: 0.274
Age, sex, PCs(1-40)
PPM001473 PGS000675
(snpnet.C_reactive_protein)
PSS000654|
European Ancestry|
23,534 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: C-reactive protein [mg/L] : 0.15954
Spearman's ρ: 0.346
Age, sex, PCs(1-40)
PPM001508 PGS000675
(snpnet.C_reactive_protein)
PSS000655|
South Asian Ancestry|
7,316 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: C-reactive protein [mg/L] : 0.13562
Spearman's ρ: 0.315
Age, sex, PCs(1-40)
PPM001543 PGS000675
(snpnet.C_reactive_protein)
PSS000656|
European Ancestry|
63,656 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: C-reactive protein [mg/L] : 0.14786
Spearman's ρ: 0.353
Age, sex, PCs(1-40)
PPM001593 PGS000675
(snpnet.C_reactive_protein)
PSS000801|
European Ancestry|
2,128 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: C-reactive protein [mg/L] Spearman's ρ: 0.254 Age, sex
PPM001403 PGS000675
(snpnet.C_reactive_protein)
PSS000652|
African Ancestry|
6,006 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: C-reactive protein [mg/L] : 0.07691
Spearman's ρ: 0.196
Age, sex, PCs(1-40)
PPM007302 PGS000675
(snpnet.C_reactive_protein)
PSS007138|
European Ancestry|
23,721 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: C-reactive protein : 0.03906 [0.03434, 0.04378]
Incremental R2 (full-covars): 0.02747
PGS R2 (no covariates): 0.03496 [0.03048, 0.03945]
age, sex, UKB array type, Genotype PCs
PPM007303 PGS000675
(snpnet.C_reactive_protein)
PSS007139|
South Asian Ancestry|
7,404 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: C-reactive protein : 0.05308 [0.04342, 0.06274]
Incremental R2 (full-covars): 0.03091
PGS R2 (no covariates): 0.04237 [0.03364, 0.0511]
age, sex, UKB array type, Genotype PCs
PPM007304 PGS000675
(snpnet.C_reactive_protein)
PSS007140|
European Ancestry|
64,332 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: C-reactive protein : 0.03346 [0.03079, 0.03613]
Incremental R2 (full-covars): 0.02832
PGS R2 (no covariates): 0.03414 [0.03145, 0.03684]
age, sex, UKB array type, Genotype PCs
PPM007300 PGS000675
(snpnet.C_reactive_protein)
PSS007136|
African Ancestry|
6,088 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: C-reactive protein : 0.03482 [0.02607, 0.04358]
Incremental R2 (full-covars): 0.01008
PGS R2 (no covariates): 0.01186 [0.00663, 0.01709]
age, sex, UKB array type, Genotype PCs
PPM007301 PGS000675
(snpnet.C_reactive_protein)
PSS007137|
East Asian Ancestry|
1,611 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: C-reactive protein : 0.03926 [0.02122, 0.05729]
Incremental R2 (full-covars): 0.02473
PGS R2 (no covariates): 0.02923 [0.0135, 0.04496]
age, sex, UKB array type, Genotype PCs
PPM010443 PGS001946
(portability-PLR_log_CRP)
PSS009430|
European Ancestry|
18,962 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3858 [0.3736, 0.3978] sex, age, birth date, deprivation index, 16 PCs
PPM010444 PGS001946
(portability-PLR_log_CRP)
PSS009204|
European Ancestry|
3,944 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3769 [0.3497, 0.4034] sex, age, birth date, deprivation index, 16 PCs
PPM010445 PGS001946
(portability-PLR_log_CRP)
PSS008758|
European Ancestry|
6,308 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3495 [0.3276, 0.371] sex, age, birth date, deprivation index, 16 PCs
PPM010446 PGS001946
(portability-PLR_log_CRP)
PSS008532|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3484 [0.2954, 0.3991] sex, age, birth date, deprivation index, 16 PCs
PPM010447 PGS001946
(portability-PLR_log_CRP)
PSS008310|
South Asian Ancestry|
5,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3629 [0.3406, 0.3847] sex, age, birth date, deprivation index, 16 PCs
PPM010448 PGS001946
(portability-PLR_log_CRP)
PSS008087|
East Asian Ancestry|
1,710 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3027 [0.2588, 0.3454] sex, age, birth date, deprivation index, 16 PCs
PPM010449 PGS001946
(portability-PLR_log_CRP)
PSS007874|
African Ancestry|
2,339 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.215 [0.1758, 0.2534] sex, age, birth date, deprivation index, 16 PCs
PPM010450 PGS001946
(portability-PLR_log_CRP)
PSS008978|
African Ancestry|
3,653 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.1982 [0.1667, 0.2292] sex, age, birth date, deprivation index, 16 PCs
PPM012159 PGS002164
(portability-ldpred2_log_CRP)
PSS009430|
European Ancestry|
18,962 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3745 [0.3621, 0.3866] sex, age, birth date, deprivation index, 16 PCs
PPM012161 PGS002164
(portability-ldpred2_log_CRP)
PSS008758|
European Ancestry|
6,308 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3368 [0.3147, 0.3585] sex, age, birth date, deprivation index, 16 PCs
PPM012162 PGS002164
(portability-ldpred2_log_CRP)
PSS008532|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3562 [0.3036, 0.4067] sex, age, birth date, deprivation index, 16 PCs
PPM012163 PGS002164
(portability-ldpred2_log_CRP)
PSS008310|
South Asian Ancestry|
5,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3591 [0.3368, 0.3811] sex, age, birth date, deprivation index, 16 PCs
PPM012164 PGS002164
(portability-ldpred2_log_CRP)
PSS008087|
East Asian Ancestry|
1,710 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.3014 [0.2574, 0.3441] sex, age, birth date, deprivation index, 16 PCs
PPM012165 PGS002164
(portability-ldpred2_log_CRP)
PSS007874|
African Ancestry|
2,339 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.2015 [0.1621, 0.2402] sex, age, birth date, deprivation index, 16 PCs
PPM012166 PGS002164
(portability-ldpred2_log_CRP)
PSS008978|
African Ancestry|
3,653 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.2093 [0.178, 0.2402] sex, age, birth date, deprivation index, 16 PCs
PPM012160 PGS002164
(portability-ldpred2_log_CRP)
PSS009204|
European Ancestry|
3,944 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: C-reactive protein Partial Correlation (partial-r): 0.364 [0.3366, 0.3909] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008532 1,124 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009430 18,962 individuals European UK (+ Ireland) UKB
PSS007136 6,088 individuals African unspecified UKB
PSS007137 1,611 individuals East Asian UKB
PSS007138 23,721 individuals European non-white British ancestry UKB
PSS007139 7,404 individuals South Asian UKB
PSS007140 64,332 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009204 3,944 individuals European Poland (NE Europe) UKB
PSS008310 5,978 individuals South Asian India (South Asia) UKB
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years
European TRAILS
PSS008978 3,653 individuals African unspecified Nigeria (West Africa) UKB
PSS008087 1,710 individuals East Asian China (East Asia) UKB
PSS000652 6,006 individuals African unspecified UKB
PSS000653 1,077 individuals East Asian UKB
PSS000654 23,534 individuals European Non-British White UKB
PSS000655 7,316 individuals South Asian UKB
PSS000656 63,656 individuals European
(British)
UKB
PSS008758 6,308 individuals European Italy (South Europe) UKB
PSS000801 2,128 individuals European Participants self-identifying as white MESA
PSS007874 2,339 individuals African American or Afro-Caribbean Carribean UKB