Trait: bone quantitative ultrasound measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004514
Description A bone quantitative ultrasound measurement is the output of a an ultrasound process in which bones are assayed using ultrasound and information about bone density, cortical thickness, elasticity and microarchitecture may be returned.
Trait category
Other measurement
Synonyms 2 synonyms
  • bone quantitative ultrasound
  • broadband ultrasound attenuation
Child trait(s) calcaneal bone quantitative ultrasound measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "bone quantitative ultrasound measurement" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000657
(gSOS)
PGP000120 |
Forgetta V et al. PLoS Med (2020)
Heel quantitative ultrasound speed of sound (SOS) calcaneal bone quantitative ultrasound measurement 21,716
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz - Check Terms/Licenses
PGS000951
(GBE_INI3144)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Heel Broadband ultrasound attenuation, direct entry bone quantitative ultrasound measurement 13,735
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000951/ScoringFiles/PGS000951.txt.gz
PGS000952
(GBE_INI3147)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 14,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000952/ScoringFiles/PGS000952.txt.gz
PGS000953
(GBE_INI4101)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Left heel broadband ultrasound attenuation bone quantitative ultrasound measurement 7,688
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000953/ScoringFiles/PGS000953.txt.gz
PGS000954
(GBE_INI4104)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Left heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 9,272
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000954/ScoringFiles/PGS000954.txt.gz
PGS000955
(GBE_INI4120)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Right heel broadband ultrasound attenuation bone quantitative ultrasound measurement 7,069
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000955/ScoringFiles/PGS000955.txt.gz
PGS000956
(GBE_INI4123)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Right heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 9,756
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000956/ScoringFiles/PGS000956.txt.gz
PGS001529
(GBE_INI3146)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Speed of sound through heel calcaneal bone quantitative ultrasound measurement 13,172
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001529/ScoringFiles/PGS001529.txt.gz
PGS001530
(GBE_INI4103)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Speed of sound through heel (L) calcaneal bone quantitative ultrasound measurement 8,419
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001530/ScoringFiles/PGS001530.txt.gz
PGS001531
(GBE_INI4122)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Speed of sound through heel (R) calcaneal bone quantitative ultrasound measurement 8,912
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001531/ScoringFiles/PGS001531.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001343 PGS000657
(gSOS)
PSS000586|
European Ancestry|
4,741 individuals
PGP000120 |
Forgetta V et al. PLoS Med (2020)
Reported Trait: Heel bone speed of sound : 0.2318 [0.2266, 0.2369]
PPM001344 PGS000657
(gSOS)
PSS000585|
Multi-ancestry (including European)|
21,408 individuals
PGP000120 |
Forgetta V et al. PLoS Med (2020)
Reported Trait: Screening incorporating a gSOS-based screening step Positive Predictive Value (PPV): 0.954
Reduction in individuals requiring Clinical-Risk-Factor FRAX tests (%): 37.0
Percent reduction in individuals requiring BMD FRAX Tests (%): 41.0
PPM001867 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.66, 0.79] Age, sex
PPM001852 PGS000657
(gSOS)
PSS000937|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.65, 0.71]
PPM001853 PGS000657
(gSOS)
PSS000937|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.64, 0.73] Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS
PPM001854 PGS000657
(gSOS)
PSS000936|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.67, 0.87] Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] Basline fracture risk (FRAX), fracture-related drug use
PPM001855 PGS000657
(gSOS)
PSS000936|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.64, 0.78]
PPM001856 PGS000657
(gSOS)
PSS000936|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.64, 0.89] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS
PPM001857 PGS000657
(gSOS)
PSS000933|
European Ancestry|
12,678 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture in fracture-related drug users OR: 0.78 [0.68, 0.88] Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] Basline fracture risk (FRAX)
PPM001858 PGS000657
(gSOS)
PSS000932|
European Ancestry|
12,678 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: incident hip fracture in fracture-related drug users OR: 0.77 [0.61, 0.98] Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] Basline fracture risk (FRAX)
PPM001859 PGS000657
(gSOS)
PSS000935|
European Ancestry|
67,336 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs OR: 0.57 [0.54, 0.61] Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] Basline fracture risk (FRAX)
PPM001860 PGS000657
(gSOS)
PSS000934|
European Ancestry|
67,336 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs OR: 0.36 [0.3, 0.43] Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] Basline fracture risk (FRAX)
PPM001861 PGS000657
(gSOS)
PSS000951|
European Ancestry|
90,172 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture AUROC: 0.734 [0.727, 0.74] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.68 [1.47, 1.89] Age, sex
PPM001862 PGS000657
(gSOS)
PSS000950|
European Ancestry|
90,172 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture AUROC: 0.798 [0.791, 0.805] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.2 [1.02, 1.41] Age, sex
PPM001863 PGS000657
(gSOS)
PSS000944|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture C-index: 0.623 [0.603, 0.642] Sex
PPM001864 PGS000657
(gSOS)
PSS000943|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture C-index: 0.672 [0.65, 0.695] Sex
PPM001865 PGS000657
(gSOS)
PSS000948|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.65, 0.72] AUROC: 0.68 [0.673, 0.688] Age, sex
PPM001868 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.76 [0.69, 0.85] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001869 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.61, 0.78] Age, sex
PPM001870 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.61, 0.85] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001871 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.68, 0.81] Age, sex
PPM001872 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.68, 0.83] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001873 PGS000657
(gSOS)
PSS000938|
East Asian Ancestry|
25,034 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.79 [0.71, 0.88] Age, sex Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001874 PGS000657
(gSOS)
PSS000938|
East Asian Ancestry|
25,034 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.74, 0.92] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001875 PGS000657
(gSOS)
PSS000947|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.73 [0.63, 0.84] AUROC: 0.739 [0.724, 0.754] Age, sex
PPM001876 PGS000657
(gSOS)
PSS000947|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.86] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001877 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.73 [0.64, 0.83] Age, sex
PPM001878 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.87] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001879 PGS000657
(gSOS)
PSS000939|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.63, 0.93] Age, sex
PPM001880 PGS000657
(gSOS)
PSS000939|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.58, 0.95] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001881 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.7, 0.84] Age, sex
PPM001882 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.84] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM001883 PGS000657
(gSOS)
PSS000949|
European Ancestry|
4,717 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.71 [0.59, 0.85] Clinical risk factor-based score (FRAX-CRF)
PPM001884 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.67, 0.81] Clinical risk factor-based score (FRAX-CRF)
PPM001885 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.63, 0.81] Clinical risk factor-based score (FRAX-CRF)
PPM001886 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.77 [0.7, 0.84] Clinical risk factor-based score (FRAX-CRF)
PPM001887 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.65, 0.83] Clinical risk factor-based score (FRAX-CRF)
PPM001888 PGS000657
(gSOS)
PSS000939|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.8 [0.67, 0.96] Clinical risk factor-based score (FRAX-CRF)
PPM001889 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.69, 0.84] Clinical risk factor-based score (FRAX-CRF)
PPM001890 PGS000657
(gSOS)
PSS000949|
European Ancestry|
4,717 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.9] Age, sex, measured femoral neck bone mineral density
PPM001891 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] Age, sex, measured femoral neck bone mineral density
PPM001892 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.68, 0.88] Age, sex, measured femoral neck bone mineral density
PPM001893 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] Age, sex, measured femoral neck bone mineral density
PPM001894 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.85 [0.75, 0.97] Age, sex, measured femoral neck bone mineral density
PPM001895 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.83 [0.76, 0.93] Age, sex, measured femoral neck bone mineral density
PPM001896 PGS000657
(gSOS)
PSS000949|
European Ancestry|
4,717 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.89] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001897 PGS000657
(gSOS)
PSS000942|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.71, 0.85] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001898 PGS000657
(gSOS)
PSS000940|
European Ancestry|
1,880 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.66, 0.85] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001899 PGS000657
(gSOS)
PSS000946|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.89] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001900 PGS000657
(gSOS)
PSS000941|
European Ancestry|
4,663 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.87] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001901 PGS000657
(gSOS)
PSS000945|
European Ancestry|
3,615 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture OR: 0.8 [0.73, 0.88] Clinical risk factor-based score including bone mineral density (FRAX-BMD)
PPM001902 PGS000657
(gSOS)
PSS000944|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture C-index: 0.66 [0.641, 0.679] Clinical risk factor-based score (FRAX-CRF)
PPM001903 PGS000657
(gSOS)
PSS000943|
European Ancestry|
8,278 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident hip fracture C-index: 0.682 [0.66, 0.704] Clinical risk factor-based score (FRAX-CRF)
PPM001851 PGS000657
(gSOS)
PSS000937|
European Ancestry|
80,014 individuals
PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] Basline fracture risk (FRAX), fracture-related drug use
PPM001866 PGS000657
(gSOS)
PSS000948|
European Ancestry|
80,014 individuals
PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis
PPM007075 PGS001529
(GBE_INI3146)
PSS007231|
African Ancestry|
1,434 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel : 0.03275 [0.02202, 0.04347]
Incremental R2 (full-covars): 0.0181
PGS R2 (no covariates): 0.01912 [0.01081, 0.02743]
age, sex, UKB array type, Genotype PCs
PPM007076 PGS001529
(GBE_INI3146)
PSS007232|
East Asian Ancestry|
500 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel : 0.10987 [0.07399, 0.14575]
Incremental R2 (full-covars): 0.07069
PGS R2 (no covariates): 0.08324 [0.05108, 0.11541]
age, sex, UKB array type, Genotype PCs
PPM007077 PGS001529
(GBE_INI3146)
PSS007233|
European Ancestry|
7,691 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel : 0.17225 [0.16143, 0.18307]
Incremental R2 (full-covars): 0.13354
PGS R2 (no covariates): 0.13618 [0.12614, 0.14622]
age, sex, UKB array type, Genotype PCs
PPM007078 PGS001529
(GBE_INI3146)
PSS007234|
South Asian Ancestry|
1,449 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel : 0.11013 [0.09349, 0.12678]
Incremental R2 (full-covars): 0.08026
PGS R2 (no covariates): 0.08576 [0.07067, 0.10085]
age, sex, UKB array type, Genotype PCs
PPM007079 PGS001529
(GBE_INI3146)
PSS007235|
European Ancestry|
24,146 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel : 0.18117 [0.17451, 0.18783]
Incremental R2 (full-covars): 0.13986
PGS R2 (no covariates): 0.14001 [0.13386, 0.14616]
age, sex, UKB array type, Genotype PCs
PPM007095 PGS001530
(GBE_INI4103)
PSS007281|
African Ancestry|
3,560 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (L) : 0.02043 [0.01363, 0.02724]
Incremental R2 (full-covars): 0.00372
PGS R2 (no covariates): 0.00552 [0.00193, 0.00911]
age, sex, UKB array type, Genotype PCs
PPM007096 PGS001530
(GBE_INI4103)
PSS007282|
East Asian Ancestry|
781 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (L) : 0.1024 [0.07518, 0.12962]
Incremental R2 (full-covars): 0.0813
PGS R2 (no covariates): 0.08045 [0.05573, 0.10516]
age, sex, UKB array type, Genotype PCs
PPM007097 PGS001530
(GBE_INI4103)
PSS007283|
European Ancestry|
10,636 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (L) : 0.16053 [0.15218, 0.16889]
Incremental R2 (full-covars): 0.10916
PGS R2 (no covariates): 0.11118 [0.10382, 0.11854]
age, sex, UKB array type, Genotype PCs
PPM007098 PGS001530
(GBE_INI4103)
PSS007284|
South Asian Ancestry|
5,043 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (L) : 0.07631 [0.06501, 0.0876]
Incremental R2 (full-covars): 0.05214
PGS R2 (no covariates): 0.05376 [0.04404, 0.06347]
age, sex, UKB array type, Genotype PCs
PPM007099 PGS001530
(GBE_INI4103)
PSS007285|
European Ancestry|
25,716 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (L) : 0.16377 [0.15866, 0.16887]
Incremental R2 (full-covars): 0.11885
PGS R2 (no covariates): 0.118 [0.11343, 0.12257]
age, sex, UKB array type, Genotype PCs
PPM007105 PGS001531
(GBE_INI4122)
PSS007311|
African Ancestry|
3,592 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (R) : 0.02141 [0.01445, 0.02837]
Incremental R2 (full-covars): 0.0063
PGS R2 (no covariates): 0.00698 [0.00295, 0.01101]
age, sex, UKB array type, Genotype PCs
PPM007106 PGS001531
(GBE_INI4122)
PSS007312|
East Asian Ancestry|
782 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (R) : 0.09852 [0.07171, 0.12534]
Incremental R2 (full-covars): 0.07672
PGS R2 (no covariates): 0.07776 [0.05339, 0.10214]
age, sex, UKB array type, Genotype PCs
PPM007107 PGS001531
(GBE_INI4122)
PSS007313|
European Ancestry|
10,633 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (R) : 0.16134 [0.15298, 0.16971]
Incremental R2 (full-covars): 0.10988
PGS R2 (no covariates): 0.11176 [0.10439, 0.11914]
age, sex, UKB array type, Genotype PCs
PPM007108 PGS001531
(GBE_INI4122)
PSS007314|
South Asian Ancestry|
5,041 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (R) : 0.07785 [0.06646, 0.08924]
Incremental R2 (full-covars): 0.05682
PGS R2 (no covariates): 0.05742 [0.04742, 0.06742]
age, sex, UKB array type, Genotype PCs
PPM007109 PGS001531
(GBE_INI4122)
PSS007315|
European Ancestry|
25,728 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Speed of sound through heel (R) : 0.17507 [0.16986, 0.18028]
Incremental R2 (full-covars): 0.12574
PGS R2 (no covariates): 0.12479 [0.12013, 0.12946]
age, sex, UKB array type, Genotype PCs
PPM007591 PGS000953
(GBE_INI4101)
PSS007278|
European Ancestry|
10,636 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (L) : 0.18344 [0.17475, 0.19212]
Incremental R2 (full-covars): 0.09737
PGS R2 (no covariates): 0.09704 [0.09006, 0.10403]
age, sex, UKB array type, Genotype PCs
PPM007579 PGS000951
(GBE_INI3144)
PSS007226|
African Ancestry|
2,252 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel Broadband ultrasound attenuation, direct entry : 0.03865 [0.02946, 0.04783]
Incremental R2 (full-covars): 0.01472
PGS R2 (no covariates): 0.01564 [0.00966, 0.02163]
age, sex, UKB array type, Genotype PCs
PPM007580 PGS000951
(GBE_INI3144)
PSS007227|
East Asian Ancestry|
795 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel Broadband ultrasound attenuation, direct entry : 0.09355 [0.06728, 0.11982]
Incremental R2 (full-covars): 0.05152
PGS R2 (no covariates): 0.05375 [0.03296, 0.07454]
age, sex, UKB array type, Genotype PCs
PPM007581 PGS000951
(GBE_INI3144)
PSS007228|
European Ancestry|
12,376 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel Broadband ultrasound attenuation, direct entry : 0.1963 [0.18746, 0.20514]
Incremental R2 (full-covars): 0.11678
PGS R2 (no covariates): 0.11778 [0.11026, 0.1253]
age, sex, UKB array type, Genotype PCs
PPM007582 PGS000951
(GBE_INI3144)
PSS007229|
South Asian Ancestry|
2,312 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel Broadband ultrasound attenuation, direct entry : 0.09722 [0.08476, 0.10969]
Incremental R2 (full-covars): 0.05231
PGS R2 (no covariates): 0.05582 [0.04594, 0.06569]
age, sex, UKB array type, Genotype PCs
PPM007583 PGS000951
(GBE_INI3144)
PSS007230|
European Ancestry|
38,830 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel Broadband ultrasound attenuation, direct entry : 0.20634 [0.2009, 0.21179]
Incremental R2 (full-covars): 0.11895
PGS R2 (no covariates): 0.11837 [0.11379, 0.12295]
age, sex, UKB array type, Genotype PCs
PPM007584 PGS000952
(GBE_INI3147)
PSS007236|
African Ancestry|
2,253 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry : 0.03462 [0.02589, 0.04335]
Incremental R2 (full-covars): 0.01756
PGS R2 (no covariates): 0.01829 [0.01183, 0.02474]
age, sex, UKB array type, Genotype PCs
PPM007585 PGS000952
(GBE_INI3147)
PSS007237|
East Asian Ancestry|
795 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry : 0.09836 [0.07157, 0.12516]
Incremental R2 (full-covars): 0.06627
PGS R2 (no covariates): 0.06933 [0.04611, 0.09255]
age, sex, UKB array type, Genotype PCs
PPM007586 PGS000952
(GBE_INI3147)
PSS007238|
European Ancestry|
12,376 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry : 0.18809 [0.17935, 0.19684]
Incremental R2 (full-covars): 0.13505
PGS R2 (no covariates): 0.13677 [0.12885, 0.1447]
age, sex, UKB array type, Genotype PCs
PPM007587 PGS000952
(GBE_INI3147)
PSS007239|
South Asian Ancestry|
2,312 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry : 0.10193 [0.08923, 0.11462]
Incremental R2 (full-covars): 0.06757
PGS R2 (no covariates): 0.07119 [0.06022, 0.08216]
age, sex, UKB array type, Genotype PCs
PPM007588 PGS000952
(GBE_INI3147)
PSS007240|
European Ancestry|
38,834 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry : 0.1966 [0.19122, 0.20198]
Incremental R2 (full-covars): 0.1419
PGS R2 (no covariates): 0.14158 [0.13671, 0.14646]
age, sex, UKB array type, Genotype PCs
PPM007589 PGS000953
(GBE_INI4101)
PSS007276|
African Ancestry|
3,559 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (L) : 0.03758 [0.02851, 0.04665]
Incremental R2 (full-covars): 0.00859
PGS R2 (no covariates): 0.00936 [0.0047, 0.01402]
age, sex, UKB array type, Genotype PCs
PPM007590 PGS000953
(GBE_INI4101)
PSS007277|
East Asian Ancestry|
781 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (L) : 0.10345 [0.07612, 0.13077]
Incremental R2 (full-covars): 0.07295
PGS R2 (no covariates): 0.07189 [0.0483, 0.09547]
age, sex, UKB array type, Genotype PCs
PPM007592 PGS000953
(GBE_INI4101)
PSS007279|
South Asian Ancestry|
5,043 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (L) : 0.08632 [0.07443, 0.0982]
Incremental R2 (full-covars): 0.04895
PGS R2 (no covariates): 0.04892 [0.03961, 0.05823]
age, sex, UKB array type, Genotype PCs
PPM007593 PGS000953
(GBE_INI4101)
PSS007280|
European Ancestry|
25,716 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (L) : 0.19239 [0.18705, 0.19774]
Incremental R2 (full-covars): 0.09654
PGS R2 (no covariates): 0.09575 [0.09152, 0.09997]
age, sex, UKB array type, Genotype PCs
PPM007594 PGS000954
(GBE_INI4104)
PSS007286|
African Ancestry|
3,560 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) : 0.02571 [0.01811, 0.0333]
Incremental R2 (full-covars): 0.00528
PGS R2 (no covariates): 0.00688 [0.00288, 0.01088]
age, sex, UKB array type, Genotype PCs
PPM007595 PGS000954
(GBE_INI4104)
PSS007287|
East Asian Ancestry|
781 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) : 0.10298 [0.0757, 0.13026]
Incremental R2 (full-covars): 0.08296
PGS R2 (no covariates): 0.082 [0.05708, 0.10691]
age, sex, UKB array type, Genotype PCs
PPM007596 PGS000954
(GBE_INI4104)
PSS007288|
European Ancestry|
10,636 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) : 0.17491 [0.16634, 0.18348]
Incremental R2 (full-covars): 0.11202
PGS R2 (no covariates): 0.11274 [0.10534, 0.12014]
age, sex, UKB array type, Genotype PCs
PPM007597 PGS000954
(GBE_INI4104)
PSS007289|
South Asian Ancestry|
5,043 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) : 0.08121 [0.06962, 0.0928]
Incremental R2 (full-covars): 0.05294
PGS R2 (no covariates): 0.05414 [0.0444, 0.06389]
age, sex, UKB array type, Genotype PCs
PPM007598 PGS000954
(GBE_INI4104)
PSS007290|
European Ancestry|
25,716 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) : 0.17984 [0.17459, 0.18509]
Incremental R2 (full-covars): 0.11708
PGS R2 (no covariates): 0.11589 [0.11135, 0.12043]
age, sex, UKB array type, Genotype PCs
PPM007599 PGS000955
(GBE_INI4120)
PSS007306|
African Ancestry|
3,591 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (R) : 0.03102 [0.02273, 0.03932]
Incremental R2 (full-covars): 0.0053
PGS R2 (no covariates): 0.00612 [0.00234, 0.0099]
age, sex, UKB array type, Genotype PCs
PPM007600 PGS000955
(GBE_INI4120)
PSS007307|
East Asian Ancestry|
782 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (R) : 0.1074 [0.07968, 0.13512]
Incremental R2 (full-covars): 0.06527
PGS R2 (no covariates): 0.06337 [0.04102, 0.08571]
age, sex, UKB array type, Genotype PCs
PPM007601 PGS000955
(GBE_INI4120)
PSS007308|
European Ancestry|
10,633 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (R) : 0.18118 [0.17253, 0.18984]
Incremental R2 (full-covars): 0.09282
PGS R2 (no covariates): 0.09341 [0.08653, 0.10029]
age, sex, UKB array type, Genotype PCs
PPM007602 PGS000955
(GBE_INI4120)
PSS007309|
South Asian Ancestry|
5,040 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (R) : 0.08322 [0.07151, 0.09493]
Incremental R2 (full-covars): 0.05145
PGS R2 (no covariates): 0.05095 [0.04147, 0.06044]
age, sex, UKB array type, Genotype PCs
PPM007603 PGS000955
(GBE_INI4120)
PSS007310|
European Ancestry|
25,727 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel broadband ultrasound attenuation (R) : 0.20708 [0.20164, 0.21253]
Incremental R2 (full-covars): 0.10115
PGS R2 (no covariates): 0.10011 [0.09582, 0.10441]
age, sex, UKB array type, Genotype PCs
PPM007604 PGS000956
(GBE_INI4123)
PSS007316|
African Ancestry|
3,592 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) : 0.02463 [0.01719, 0.03208]
Incremental R2 (full-covars): 0.00617
PGS R2 (no covariates): 0.00698 [0.00295, 0.01101]
age, sex, UKB array type, Genotype PCs
PPM007605 PGS000956
(GBE_INI4123)
PSS007317|
East Asian Ancestry|
782 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) : 0.09886 [0.07201, 0.12571]
Incremental R2 (full-covars): 0.07542
PGS R2 (no covariates): 0.07555 [0.05147, 0.09963]
age, sex, UKB array type, Genotype PCs
PPM007606 PGS000956
(GBE_INI4123)
PSS007318|
European Ancestry|
10,633 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) : 0.17521 [0.16663, 0.18378]
Incremental R2 (full-covars): 0.11145
PGS R2 (no covariates): 0.11271 [0.10531, 0.12011]
age, sex, UKB array type, Genotype PCs
PPM007607 PGS000956
(GBE_INI4123)
PSS007319|
South Asian Ancestry|
5,041 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) : 0.08263 [0.07095, 0.0943]
Incremental R2 (full-covars): 0.05817
PGS R2 (no covariates): 0.05816 [0.0481, 0.06821]
age, sex, UKB array type, Genotype PCs
PPM007608 PGS000956
(GBE_INI4123)
PSS007320|
European Ancestry|
25,728 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) : 0.19359 [0.18823, 0.19894]
Incremental R2 (full-covars): 0.1242
PGS R2 (no covariates): 0.12266 [0.11802, 0.1273]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000940 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit.
[
  • 337 cases
  • , 1,543 controls
]
,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
European MrOS-SWE
PSS000941 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 273 cases
  • , 4,390 controls
]
,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000942 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 560 cases
  • , 4,103 controls
]
,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000943 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 829 cases
  • , 7,449 controls
]
,
56.33 % Male samples
European MrOS-USA, SOF
PSS000944 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,267 cases
  • , 7,011 controls
]
,
56.33 % Male samples
European MrOS-USA, SOF
PSS000945 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 556 cases
  • , 3,059 controls
]
,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European SOF
PSS000946 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 707 cases
  • , 2,908 controls
]
,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European SOF
PSS000947 Cases included individuals with a hip fracture that occurred after the baseline visit.
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB
PSS000948 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722.
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB
PSS000949 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722.
[
  • 125 cases
  • , 4,592 controls
]
European UKB
PSS000950 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,167 cases
  • , 89,005 controls
]
,
31.61 % Male samples
European MrOS-SWE, MrOS-USA, SOF, UKB
PSS000951 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. UKB cohort: Sitespecific major osteoporotic fractures were defined basedon ICD10 codes of primary diagnoses (M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722) and self-reported medical history. Range = [4.5, 14.5] years
[
  • 2,793 cases
  • , 87,379 controls
]
,
31.61 % Male samples
European MrOS-SWE, MrOS-USA, SOF, UKB
PSS007231 1,434 individuals African unspecified UKB
PSS007232 500 individuals East Asian UKB
PSS007233 7,691 individuals European non-white British ancestry UKB
PSS007234 1,449 individuals South Asian UKB
PSS007235 24,146 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007230 38,830 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007228 12,376 individuals European non-white British ancestry UKB
PSS007238 12,376 individuals European non-white British ancestry UKB
PSS007239 2,312 individuals South Asian UKB
PSS007240 38,834 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS000585 4,741 individuals,
47.5 % Male samples
Mean = 55.8 years
Sd = 7.6 years
European UKB
PSS000585 6,704 individuals,
49.3 % Male samples
Mean = 62.6 years
Sd = 9.9 years
European, NR CLSA
PSS000585 3,426 individuals,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European, NR SOF
PSS000585 4,657 individuals,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000585 1,880 individuals,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
European
(Swedish)
MrOS-SWE
PSS000586 4,741 individuals,
47.5 % Male samples
Mean = 55.8 years
Sd = 7.6 years
European UKB
PSS007236 2,253 individuals African unspecified UKB
PSS007229 2,312 individuals South Asian UKB
PSS007237 795 individuals East Asian UKB
PSS007276 3,559 individuals African unspecified UKB
PSS007277 781 individuals East Asian UKB
PSS007278 10,636 individuals European non-white British ancestry UKB
PSS007279 5,043 individuals South Asian UKB
PSS007280 25,716 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007281 3,560 individuals African unspecified UKB
PSS007282 781 individuals East Asian UKB
PSS007283 10,636 individuals European non-white British ancestry UKB
PSS007284 5,043 individuals South Asian UKB
PSS007285 25,716 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007286 3,560 individuals African unspecified UKB
PSS007287 781 individuals East Asian UKB
PSS007288 10,636 individuals European non-white British ancestry UKB
PSS007289 5,043 individuals South Asian UKB
PSS007290 25,716 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007306 3,591 individuals African unspecified UKB
PSS007307 782 individuals East Asian UKB
PSS007308 10,633 individuals European non-white British ancestry UKB
PSS007309 5,040 individuals South Asian UKB
PSS007310 25,727 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007311 3,592 individuals African unspecified UKB
PSS007312 782 individuals East Asian UKB
PSS007313 10,633 individuals European non-white British ancestry UKB
PSS007314 5,041 individuals South Asian UKB
PSS007315 25,728 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007316 3,592 individuals African unspecified UKB
PSS007317 782 individuals East Asian UKB
PSS007318 10,633 individuals European non-white British ancestry UKB
PSS007319 5,041 individuals South Asian UKB
PSS007320 25,728 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS007227 795 individuals East Asian UKB
PSS007226 2,252 individuals African unspecified UKB
PSS000932 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 68 cases
  • , 12,610 controls
]
,
40.52 % Male samples
Mean = 58.6 years
Sd = 7.7 years
European UKB
PSS000933 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 256 cases
  • , 12,422 controls
]
,
40.52 % Male samples
Mean = 58.6 years
Sd = 7.6 years
European UKB
PSS000934 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322
[
  • 141 cases
  • , 67,195 controls
]
,
46.27 % Male samples
Mean = 56.5 years
Sd = 8.2 years
European UKB
PSS000935 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321
[
  • 933 cases
  • , 66,403 controls
]
,
46.27 % Male samples
Mean = 56.5 years
Sd = 8.1 years
European UKB
PSS000936 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.1 years
European UKB
PSS000937 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB
PSS000938 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit.
[
  • 323 cases
  • , 24,711 controls
]
,
42.7 % Male samples
Mean = 53.7 years
Sd = 11.0 years
East Asian CKB
PSS000939 Cases included individuals with a hip fracture that occurred after the baseline visit.
[
  • 129 cases
  • , 1,751 controls
]
,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
European MrOS-SWE