Trait: creatinine measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004518
Description A creatinine measurement is a measure of the metabolite creatinine in a sample. For example, in the serum, where it can be used in assessment of kidney function.
Trait category
Other measurement
Synonyms 3 synonyms
  • creatinine levels
  • serum creatinine levels
  • serum creatinine measurement
Mapped term NCIt:C61023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000678
(snpnet.Creatinine)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Creatinine [umol/L] creatinine measurement 21,027
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000678/ScoringFiles/PGS000678.txt.gz - Check Terms/Licenses
PGS001945
(portability-PLR_log_creatinine)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Creatinine creatinine measurement 76,800
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001945/ScoringFiles/PGS001945.txt.gz
PGS002163
(portability-ldpred2_log_creatinine)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Creatinine creatinine measurement 835,964
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002163/ScoringFiles/PGS002163.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001406 PGS000678
(snpnet.Creatinine)
PSS000667|
African Ancestry|
6,016 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine [umol/L] : 0.37051
Spearman's ρ: 0.146
Age, sex, PCs(1-40)
PPM001441 PGS000678
(snpnet.Creatinine)
PSS000668|
East Asian Ancestry|
1,081 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine [umol/L] : 0.44314
Spearman's ρ: 0.229
Age, sex, PCs(1-40)
PPM001476 PGS000678
(snpnet.Creatinine)
PSS000674|
European Ancestry|
23,576 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine [umol/L] : 0.3939
Spearman's ρ: 0.325
Age, sex, PCs(1-40)
PPM001511 PGS000678
(snpnet.Creatinine)
PSS000675|
South Asian Ancestry|
7,339 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine [umol/L] : 0.40587
Spearman's ρ: 0.283
Age, sex, PCs(1-40)
PPM001546 PGS000678
(snpnet.Creatinine)
PSS000676|
European Ancestry|
63,758 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine [umol/L] : 0.41565
Spearman's ρ: 0.337
Age, sex, PCs(1-40)
PPM001579 PGS000678
(snpnet.Creatinine)
PSS000800|
European Ancestry|
2,129 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine [umol/L] Spearman's ρ: 0.24 Age, sex
PPM007315 PGS000678
(snpnet.Creatinine)
PSS007131|
African Ancestry|
6,097 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Creatinine : 0.1805 [0.16358, 0.19743]
Incremental R2 (full-covars): 0.00023
PGS R2 (no covariates): 0.0048 [0.00145, 0.00815]
age, sex, UKB array type, Genotype PCs
PPM007316 PGS000678
(snpnet.Creatinine)
PSS007132|
East Asian Ancestry|
1,615 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Creatinine : 0.30903 [0.27263, 0.34543]
Incremental R2 (full-covars): 0.0006
PGS R2 (no covariates): 0.01099 [0.00116, 0.02081]
age, sex, UKB array type, Genotype PCs
PPM007317 PGS000678
(snpnet.Creatinine)
PSS007133|
European Ancestry|
23,762 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Creatinine : 0.23065 [0.22147, 0.23982]
Incremental R2 (full-covars): 0.00126
PGS R2 (no covariates): 0.04345 [0.0385, 0.0484]
age, sex, UKB array type, Genotype PCs
PPM007318 PGS000678
(snpnet.Creatinine)
PSS007134|
South Asian Ancestry|
7,427 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Creatinine : 0.2107 [0.19466, 0.22675]
Incremental R2 (full-covars): 0.00063
PGS R2 (no covariates): 0.02244 [0.01595, 0.02892]
age, sex, UKB array type, Genotype PCs
PPM007319 PGS000678
(snpnet.Creatinine)
PSS007135|
European Ancestry|
64,433 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.
Reported Trait: Creatinine : 0.23859 [0.23298, 0.24421]
Incremental R2 (full-covars): 0.00127
PGS R2 (no covariates): 0.04554 [0.04246, 0.04861]
age, sex, UKB array type, Genotype PCs
PPM010441 PGS001945
(portability-PLR_log_creatinine)
PSS007883|
African Ancestry|
2,345 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.1379 [0.0978, 0.1776] sex, age, birth date, deprivation index, 16 PCs
PPM010435 PGS001945
(portability-PLR_log_creatinine)
PSS009439|
European Ancestry|
18,993 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3568 [0.3443, 0.3691] sex, age, birth date, deprivation index, 16 PCs
PPM010436 PGS001945
(portability-PLR_log_creatinine)
PSS009213|
European Ancestry|
3,950 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3499 [0.3221, 0.377] sex, age, birth date, deprivation index, 16 PCs
PPM010437 PGS001945
(portability-PLR_log_creatinine)
PSS008767|
European Ancestry|
6,322 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3344 [0.3123, 0.3562] sex, age, birth date, deprivation index, 16 PCs
PPM010438 PGS001945
(portability-PLR_log_creatinine)
PSS008541|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3425 [0.2894, 0.3936] sex, age, birth date, deprivation index, 16 PCs
PPM010439 PGS001945
(portability-PLR_log_creatinine)
PSS008319|
South Asian Ancestry|
6,003 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.2881 [0.2647, 0.3112] sex, age, birth date, deprivation index, 16 PCs
PPM010440 PGS001945
(portability-PLR_log_creatinine)
PSS008096|
East Asian Ancestry|
1,716 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.2465 [0.2013, 0.2907] sex, age, birth date, deprivation index, 16 PCs
PPM010442 PGS001945
(portability-PLR_log_creatinine)
PSS008987|
African Ancestry|
3,655 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.1382 [0.1062, 0.17] sex, age, birth date, deprivation index, 16 PCs
PPM012151 PGS002163
(portability-ldpred2_log_creatinine)
PSS009439|
European Ancestry|
18,993 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.353 [0.3405, 0.3654] sex, age, birth date, deprivation index, 16 PCs
PPM012152 PGS002163
(portability-ldpred2_log_creatinine)
PSS009213|
European Ancestry|
3,950 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3476 [0.3198, 0.3748] sex, age, birth date, deprivation index, 16 PCs
PPM012153 PGS002163
(portability-ldpred2_log_creatinine)
PSS008767|
European Ancestry|
6,322 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3305 [0.3083, 0.3523] sex, age, birth date, deprivation index, 16 PCs
PPM012154 PGS002163
(portability-ldpred2_log_creatinine)
PSS008541|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.3278 [0.2741, 0.3794] sex, age, birth date, deprivation index, 16 PCs
PPM012157 PGS002163
(portability-ldpred2_log_creatinine)
PSS007883|
African Ancestry|
2,345 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.1607 [0.1208, 0.2] sex, age, birth date, deprivation index, 16 PCs
PPM012158 PGS002163
(portability-ldpred2_log_creatinine)
PSS008987|
African Ancestry|
3,655 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.1261 [0.0939, 0.1579] sex, age, birth date, deprivation index, 16 PCs
PPM012155 PGS002163
(portability-ldpred2_log_creatinine)
PSS008319|
South Asian Ancestry|
6,003 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.2731 [0.2495, 0.2964] sex, age, birth date, deprivation index, 16 PCs
PPM012156 PGS002163
(portability-ldpred2_log_creatinine)
PSS008096|
East Asian Ancestry|
1,716 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Creatinine Partial Correlation (partial-r): 0.24 [0.1946, 0.2844] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007883 2,345 individuals African American or Afro-Caribbean Carribean UKB
PSS008541 1,124 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009439 18,993 individuals European UK (+ Ireland) UKB
PSS007131 6,097 individuals African unspecified UKB
PSS007132 1,615 individuals East Asian UKB
PSS007133 23,762 individuals European non-white British ancestry UKB
PSS007134 7,427 individuals South Asian UKB
PSS007135 64,433 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS009213 3,950 individuals European Poland (NE Europe) UKB
PSS008319 6,003 individuals South Asian India (South Asia) UKB
PSS008987 3,655 individuals African unspecified Nigeria (West Africa) UKB
PSS008096 1,716 individuals East Asian China (East Asia) UKB
PSS000667 6,016 individuals African unspecified UKB
PSS000668 1,081 individuals East Asian UKB
PSS000674 23,576 individuals European Non-British White UKB
PSS000800 2,129 individuals European Participants self-identifying as white MESA
PSS008767 6,322 individuals European Italy (South Europe) UKB
PSS000675 7,339 individuals South Asian UKB
PSS000676 63,758 individuals European
(British)
UKB