Trait: mean corpuscular volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004526
Description A mean corpuscular volume is the result of calculation of the mean volume of erythrocytes in a blood sample.
Trait category
Hematological measurement
Synonyms 2 synonyms
  • MCV
  • mean cell volume
Mapped term MedDRA:10027008

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000101
(mcv)
PGP000051 |
Xu Y et al. Cell Genom (2022)
Mean corpuscular volume mean corpuscular volume 25,001
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000101/ScoringFiles/PGS000101.txt.gz
PGS000176
(mcv)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean corpuscular volume mean corpuscular volume 685
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000176/ScoringFiles/PGS000176.txt.gz
PGS000181
(mscv)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean sphered corpuscular volume mean corpuscular volume 761
-
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000181/ScoringFiles/PGS000181.txt.gz
PGS001220
(GBE_INI30040)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Mean corpuscular volume mean corpuscular volume 17,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001220/ScoringFiles/PGS001220.txt.gz
PGS001990
(portability-PLR_MCV)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Mean corpuscular volume mean corpuscular volume 47,916
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001990/ScoringFiles/PGS001990.txt.gz
PGS002207
(portability-ldpred2_MCV)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Mean corpuscular volume mean corpuscular volume 564,228
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002207/ScoringFiles/PGS002207.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000234 PGS000101
(mcv)
PSS000166|
European Ancestry|
81,431 individuals
PGP000051 |
Xu Y et al. Cell Genom (2022)
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.5624 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000235 PGS000101
(mcv)
PSS000140|
European Ancestry|
40,080 individuals
PGP000051 |
Xu Y et al. Cell Genom (2022)
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.47754 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000553 PGS000176
(mcv)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular volume : 0.1665 sex, age, 10 genetic PCs
PPM000532 PGS000176
(mcv)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular volume : 0.15931 sex, age, 10 genetic PCs
PPM001774 PGS000176
(mcv)
PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Mean corpuscular volume Pearson correlation coefficent (r): 0.23
PPM008634 PGS001220
(GBE_INI30040)
PSS006926|
African Ancestry|
6,139 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean corpuscular volume : 0.03909 [0.02986, 0.04833]
Incremental R2 (full-covars): 0.01317
PGS R2 (no covariates): 0.01523 [0.00932, 0.02114]
age, sex, UKB array type, Genotype PCs
PPM008635 PGS001220
(GBE_INI30040)
PSS006927|
East Asian Ancestry|
1,655 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean corpuscular volume : 0.09134 [0.06532, 0.11737]
Incremental R2 (full-covars): 0.03736
PGS R2 (no covariates): 0.05987 [0.03807, 0.08167]
age, sex, UKB array type, Genotype PCs
PPM008636 PGS001220
(GBE_INI30040)
PSS006928|
European Ancestry|
24,175 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean corpuscular volume : 0.20688 [0.19792, 0.21584]
Incremental R2 (full-covars): 0.15861
PGS R2 (no covariates): 0.17414 [0.16558, 0.1827]
age, sex, UKB array type, Genotype PCs
PPM008637 PGS001220
(GBE_INI30040)
PSS006929|
South Asian Ancestry|
7,520 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean corpuscular volume : 0.12834 [0.11451, 0.14216]
Incremental R2 (full-covars): 0.07837
PGS R2 (no covariates): 0.08395 [0.0722, 0.0957]
age, sex, UKB array type, Genotype PCs
PPM008638 PGS001220
(GBE_INI30040)
PSS006930|
European Ancestry|
65,638 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean corpuscular volume : 0.21614 [0.21064, 0.22164]
Incremental R2 (full-covars): 0.19948
PGS R2 (no covariates): 0.20189 [0.19648, 0.2073]
age, sex, UKB array type, Genotype PCs
PPM010795 PGS001990
(portability-PLR_MCV)
PSS009378|
European Ancestry|
19,423 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.4447 [0.4333, 0.4559] sex, age, birth date, deprivation index, 16 PCs
PPM010796 PGS001990
(portability-PLR_MCV)
PSS009152|
European Ancestry|
4,002 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.3969 [0.3704, 0.4228] sex, age, birth date, deprivation index, 16 PCs
PPM010797 PGS001990
(portability-PLR_MCV)
PSS008706|
European Ancestry|
6,437 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.3414 [0.3196, 0.3628] sex, age, birth date, deprivation index, 16 PCs
PPM010799 PGS001990
(portability-PLR_MCV)
PSS008258|
South Asian Ancestry|
6,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2987 [0.2756, 0.3214] sex, age, birth date, deprivation index, 16 PCs
PPM010800 PGS001990
(portability-PLR_MCV)
PSS008036|
East Asian Ancestry|
1,762 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2426 [0.1979, 0.2863] sex, age, birth date, deprivation index, 16 PCs
PPM010801 PGS001990
(portability-PLR_MCV)
PSS007822|
African Ancestry|
2,342 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2067 [0.1674, 0.2453] sex, age, birth date, deprivation index, 16 PCs
PPM010802 PGS001990
(portability-PLR_MCV)
PSS008926|
African Ancestry|
3,711 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.1227 [0.0908, 0.1543] sex, age, birth date, deprivation index, 16 PCs
PPM010798 PGS001990
(portability-PLR_MCV)
PSS008480|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2898 [0.2355, 0.3422] sex, age, birth date, deprivation index, 16 PCs
PPM012503 PGS002207
(portability-ldpred2_MCV)
PSS009378|
European Ancestry|
19,423 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.4393 [0.4279, 0.4506] sex, age, birth date, deprivation index, 16 PCs
PPM012504 PGS002207
(portability-ldpred2_MCV)
PSS009152|
European Ancestry|
4,002 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.3883 [0.3616, 0.4144] sex, age, birth date, deprivation index, 16 PCs
PPM012506 PGS002207
(portability-ldpred2_MCV)
PSS008480|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2809 [0.2264, 0.3337] sex, age, birth date, deprivation index, 16 PCs
PPM012507 PGS002207
(portability-ldpred2_MCV)
PSS008258|
South Asian Ancestry|
6,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2928 [0.2696, 0.3156] sex, age, birth date, deprivation index, 16 PCs
PPM012508 PGS002207
(portability-ldpred2_MCV)
PSS008036|
East Asian Ancestry|
1,762 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2554 [0.211, 0.2988] sex, age, birth date, deprivation index, 16 PCs
PPM012509 PGS002207
(portability-ldpred2_MCV)
PSS007822|
African Ancestry|
2,342 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.2029 [0.1636, 0.2416] sex, age, birth date, deprivation index, 16 PCs
PPM012505 PGS002207
(portability-ldpred2_MCV)
PSS008706|
European Ancestry|
6,437 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.3311 [0.3091, 0.3527] sex, age, birth date, deprivation index, 16 PCs
PPM012510 PGS002207
(portability-ldpred2_MCV)
PSS008926|
African Ancestry|
3,711 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean corpuscular volume Partial Correlation (partial-r): 0.139 [0.1072, 0.1705] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008036 1,762 individuals East Asian China (East Asia) UKB
PSS000166 81,431 individuals,
46.0 % Male samples
Mean = 57.26 years
Range = [40.15, 71.1] years
European UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS000140 40,080 individuals,
50.0 % Male samples
Mean = 43.82 years
Range = [18.0, 76.4] years
European INTERVAL
PSS008706 6,437 individuals European Italy (South Europe) UKB
PSS007822 2,342 individuals African American or Afro-Caribbean Carribean UKB
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB
PSS006926 6,139 individuals African unspecified UKB
PSS006927 1,655 individuals East Asian UKB
PSS006928 24,175 individuals European non-white British ancestry UKB
PSS006929 7,520 individuals South Asian UKB
PSS006930 65,638 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS008480 1,153 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008258 6,078 individuals South Asian India (South Asia) UKB
PSS008926 3,711 individuals African unspecified Nigeria (West Africa) UKB
PSS009152 4,002 individuals European Poland (NE Europe) UKB
PSS009378 19,423 individuals European UK (+ Ireland) UKB