Trait: mean corpuscular hemoglobin concentration

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004528
Description
  • The mean corpuscular hemoglobin concentration is a measure of the concentration of hemoglobin in a given volume of packed red blood cell
Trait category
Hematological measurement
Synonyms 6 synonyms
  • CHCM
  • Corpuscular HGB Concentration Mean
  • Corpuscular Hemoglobin Concentration Mean
  • Erythrocyte Corpuscular Hemoglobin Concentration Mean
  • MCHC
  • mean corpuscular haemoglobin concentration
Mapped term(s) NCIt:C139067

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000100
(mchc)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Mean corpuscular hemoglobin concentration mean corpuscular hemoglobin concentration 252
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000100/ScoringFiles/PGS000100.txt.gz
PGS000175
(mchc)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean corpuscular hemoglobin concentration mean corpuscular hemoglobin concentration 224
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000175/ScoringFiles/PGS000175.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000531 PGS000175
(mchc)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular hemoglobin concentration : 0.05159 sex, age, 10 genetic PCs
PPM000551 PGS000175
(mchc)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Mean corpuscular hemoglobin concentration : 0.04796 sex, age, 10 genetic PCs
PPM000233 PGS000100
(mchc)
PSS000139|
European Ancestry|
40,265 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Mean corpuscular hemoglobin concentration Pearson correlation coefficent (r): 0.2642 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000232 PGS000100
(mchc)
PSS000165|
European Ancestry|
81,570 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Mean corpuscular hemoglobin concentration Pearson correlation coefficent (r): 0.2755 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM001772 PGS000175
(mchc)
PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Mean cell hemoglobin concentration Pearson correlation coefficent (r): 0.12

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000165 81,570 individuals,
46.0 % Male samples
Mean = 57.27 years
Range = [39.98, 70.7] years
European UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000139 40,265 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000291 39,260 individuals European INTERVAL
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB