Trait: serum gamma-glutamyl transferase measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004532
Description
  • Serum gamma-glutamyl transferase level measurement is the quantification of gamma-glutamyl transferase in blood. Gamma-glutamyl transferase is used as a marker for liver/bile duct problems and alcohol abuse.
Trait category
Liver enzyme measurement
Synonyms 4 synonyms
  • GGT measurement
  • Gamma gluatamyl transferase levels
  • Gamma glutamyl transpeptidase levels
  • gamma glutamyl transferase measurement
Mapped term(s) SNOMEDCT:313849004

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000683
(snpnet.Gamma_glutamyltransferase)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Gamma glutamyltransferase [U/L] serum gamma-glutamyl transferase measurement 17,323
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000683/ScoringFiles/PGS000683.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001551 PGS000683
(snpnet.Gamma_glutamyltransferase)
PSS000693|
European Ancestry|
63,756 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Gamma glutamyltransferase [U/L] : 0.24765
Spearman's ρ: 0.375
Age, sex, PCs(1-40)
PPM001516 PGS000683
(snpnet.Gamma_glutamyltransferase)
PSS000692|
South Asian Ancestry|
7,336 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Gamma glutamyltransferase [U/L] : 0.20072
Spearman's ρ: 0.338
Age, sex, PCs(1-40)
PPM001481 PGS000683
(snpnet.Gamma_glutamyltransferase)
PSS000691|
European Ancestry|
23,560 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Gamma glutamyltransferase [U/L] : 0.26555
Spearman's ρ: 0.36
Age, sex, PCs(1-40)
PPM001446 PGS000683
(snpnet.Gamma_glutamyltransferase)
PSS000690|
East Asian Ancestry|
1,081 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Gamma glutamyltransferase [U/L] : 0.16131
Spearman's ρ: 0.33
Age, sex, PCs(1-40)
PPM001411 PGS000683
(snpnet.Gamma_glutamyltransferase)
PSS000689|
African Ancestry|
6,015 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Gamma glutamyltransferase [U/L] : 0.12099
Spearman's ρ: 0.187
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000689 6,015 individuals African unspecified UKB
PSS000690 1,081 individuals East Asian UKB
PSS000691 23,560 individuals European Non-British White UKB
PSS000692 7,336 individuals South Asian UKB
PSS000693 63,756 individuals European
(British)
UKB