Trait: total blood protein measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004536
Description
  • A total blood protein measurement is a quantification of protein in a blood sample. It is used as a marker for disease and nutrition. It is performed in the liquid portion of blood and typically measures albumin and globulin.
Trait category
Hematological measurement
Synonyms 2 synonyms
  • TBP
  • serum total protein

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000698
(snpnet.Total_protein)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Total protein [g/L] total blood protein measurement 16,420
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000698/ScoringFiles/PGS000698.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001496 PGS000698
(snpnet.Total_protein)
PSS000769|
European Ancestry|
21,516 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total protein [g/L] : 0.11654
Spearman's ρ: 0.282
Age, sex, PCs(1-40)
PPM001461 PGS000698
(snpnet.Total_protein)
PSS000768|
East Asian Ancestry|
984 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total protein [g/L] : 0.09275
Spearman's ρ: 0.247
Age, sex, PCs(1-40)
PPM001566 PGS000698
(snpnet.Total_protein)
PSS000771|
European Ancestry|
58,196 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total protein [g/L] : 0.11218
Spearman's ρ: 0.284
Age, sex, PCs(1-40)
PPM001531 PGS000698
(snpnet.Total_protein)
PSS000770|
South Asian Ancestry|
6,687 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total protein [g/L] : 0.10522
Spearman's ρ: 0.258
Age, sex, PCs(1-40)
PPM001426 PGS000698
(snpnet.Total_protein)
PSS000767|
African Ancestry|
5,573 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Total protein [g/L] : 0.04363
Spearman's ρ: 0.144
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000767 5,573 individuals African unspecified UKB
PSS000768 984 individuals East Asian UKB
PSS000769 21,516 individuals European Non-British White UKB
PSS000770 6,687 individuals South Asian UKB
PSS000771 58,196 individuals European
(British)
UKB