Trait: apolipoprotein A 1 measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004614
Description
  • Is a quantification of serum lipoprotein A. Apolipoprotein A-I, encoded in humans by the APOA1 gene and is the major protein component of high density lipoprotein (HDL) in plasma. It is is implicated as a risk factor for atherosclerotic diseases such as coronary heart disease and stroke.
Trait category
Cardiovascular measurement
Inflammatory measurement
Lipid or lipoprotein measurement
Synonyms 2 synonyms
  • Serum amyloid A-1 protein levels
  • lipoprotein A-1 levels

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000671
(snpnet.Apolipoprotein_A)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Apolipoprotein A [g/L] apolipoprotein A 1 measurement 19,324
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000671/ScoringFiles/PGS000671.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001399 PGS000671
(snpnet.Apolipoprotein_A)
PSS000637|
African Ancestry|
5,550 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Apolipoprotein A [g/L] : 0.1486
Spearman's ρ: 0.213
Age, sex, PCs(1-40)
PPM001434 PGS000671
(snpnet.Apolipoprotein_A)
PSS000638|
East Asian Ancestry|
974 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Apolipoprotein A [g/L] : 0.32046
Spearman's ρ: 0.329
Age, sex, PCs(1-40)
PPM001469 PGS000671
(snpnet.Apolipoprotein_A)
PSS000639|
European Ancestry|
21,403 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Apolipoprotein A [g/L] : 0.31504
Spearman's ρ: 0.385
Age, sex, PCs(1-40)
PPM001504 PGS000671
(snpnet.Apolipoprotein_A)
PSS000640|
South Asian Ancestry|
6,682 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Apolipoprotein A [g/L] : 0.29281
Spearman's ρ: 0.358
Age, sex, PCs(1-40)
PPM001539 PGS000671
(snpnet.Apolipoprotein_A)
PSS000641|
European Ancestry|
57,932 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Apolipoprotein A [g/L] : 0.30509
Spearman's ρ: 0.398
Age, sex, PCs(1-40)
PPM001580 PGS000671
(snpnet.Apolipoprotein_A)
PSS000795|
European Ancestry|
1,378 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Apolipoprotein A [g/L] Spearman's ρ: 0.241 Age, sex

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000795 1,378 individuals European Participants self-identifying as white MESA
PSS000637 5,550 individuals African unspecified UKB
PSS000638 974 individuals East Asian UKB
PSS000639 21,403 individuals European Non-British White UKB
PSS000640 6,682 individuals South Asian UKB
PSS000641 57,932 individuals European
(British)
UKB