Trait: IGF-1 measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004627
Description
  • Is the quantification of Insulin-like growth factor 1 (IGF-1), also called somatomedin C. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Levels of IGF-1 are known to increase in some cancers.
Trait category
Other measurement
Synonyms Insulin-Like Growth Factor 1 levels

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000687
(snpnet.IGF_1)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
IGF-1 [nmol/L] IGF-1 measurement 23,443
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000687/ScoringFiles/PGS000687.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001555 PGS000687
(snpnet.IGF_1)
PSS000713|
European Ancestry|
63,393 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.20434
Spearman's ρ: 0.369
Age, sex, PCs(1-40)
PPM001520 PGS000687
(snpnet.IGF_1)
PSS000712|
South Asian Ancestry|
7,283 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.20212
Spearman's ρ: 0.313
Age, sex, PCs(1-40)
PPM001485 PGS000687
(snpnet.IGF_1)
PSS000711|
European Ancestry|
23,453 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.22328
Spearman's ρ: 0.362
Age, sex, PCs(1-40)
PPM001450 PGS000687
(snpnet.IGF_1)
PSS000710|
East Asian Ancestry|
1,074 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.17702
Spearman's ρ: 0.258
Age, sex, PCs(1-40)
PPM001415 PGS000687
(snpnet.IGF_1)
PSS000709|
African Ancestry|
5,974 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.11454
Spearman's ρ: 0.182
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000711 23,453 individuals European Non-British White UKB
PSS000712 7,283 individuals South Asian UKB
PSS000713 63,393 individuals European
(British)
UKB
PSS000709 5,974 individuals African unspecified UKB
PSS000710 1,074 individuals East Asian UKB