Trait: intraocular pressure measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004695
Description
  • Is a quantification of intraocular pressure. Increased intraocular pressure is a heritable risk factor for primary open angle glaucoma.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000124
(IOP_AS)
PGP000061 |
MacGregor S et al. Nat Genet (2018)
Intraocular pressure intraocular pressure measurement 103
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000124/ScoringFiles/PGS000124.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000403 PGS000124
(IOP_AS)
PSS000231|
European Ancestry|
4,672 individuals
PGP000061 |
MacGregor S et al. Nat Genet (2018)
Reported Trait: Advanced glaucoma AUROC: 0.65 [0.63, 0.66] sex, first 4 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000231 Advanced primary open-angle glaucoma
[
  • 1,734 cases
  • , 2,938 controls
]
European ANZRAG Samples come from Phase 1 and Phase 2 of ANZRAG.