Trait: insomnia

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004698
Description A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep. [NCIT: P378]
Trait category
Neurological disorder
Synonyms 2 synonyms
  • insomnia
  • insomnia (disease)
Mapped terms 13 mapped terms
  • HP:0100785
  • ICD10CM:G47.0
  • ICD10WHO:G47.0
  • ICD9:780.52
  • MESH:D007319
  • MONDO:0013600
  • MedDRA:10022437
  • NCIT:C28286
  • NCIt:C28286
  • OMIM:614163
  • SCTID:193462001
  • SNOMEDCT:193462001
  • UMLS:C0393770

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000908
(PRS_Insomnia)
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Insomnia insomnia 2,746,982
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000908/ScoringFiles/PGS000908.txt.gz
PGS001932
(portability-PLR_insomnia)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Sleeplessness / insomnia insomnia 37,712
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001932/ScoringFiles/PGS001932.txt.gz
PGS002149
(portability-ldpred2_insomnia)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Sleeplessness / insomnia insomnia 926,585
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002149/ScoringFiles/PGS002149.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002950 PGS000908
(PRS_Insomnia)
PSS001293|
European Ancestry|
5,713 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Sertraline takers OR: 1.06 [0.99, 1.14] Variance explained (Nagelkerke's R2*100): 0.09 sex, age at study enrollment, genetic PCs 1-20
PPM002951 PGS000908
(PRS_Insomnia)
PSS001289|
European Ancestry|
4,362 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Escitalopram takers OR: 1.12 [1.03, 1.21] Variance explained (Nagelkerke's R2*100): 0.27 sex, age at study enrollment, genetic PCs 1-20
PPM002952 PGS000908
(PRS_Insomnia)
PSS001294|
European Ancestry|
3,964 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Venlafaxine takers OR: 1.03 [0.95, 1.11] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002953 PGS000908
(PRS_Insomnia)
PSS001285|
European Ancestry|
1,655 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Amitriptyline takers OR: 1.28 [1.07, 1.52] Variance explained (Nagelkerke's R2*100): 1.03 sex, age at study enrollment, genetic PCs 1-20
PPM002954 PGS000908
(PRS_Insomnia)
PSS001291|
European Ancestry|
1,986 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Mirtazapine takers OR: 1.03 [0.88, 1.2] Variance explained (Nagelkerke's R2*100): 0.01 sex, age at study enrollment, genetic PCs 1-20
PPM002955 PGS000908
(PRS_Insomnia)
PSS001287|
European Ancestry|
2,523 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Desvenlafaxine takers OR: 1.13 [1.03, 1.25] Variance explained (Nagelkerke's R2*100): 0.38 sex, age at study enrollment, genetic PCs 1-20
PPM002956 PGS000908
(PRS_Insomnia)
PSS001286|
European Ancestry|
2,585 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Citalopram takers OR: 1.08 [0.96, 1.21] Variance explained (Nagelkerke's R2*100): 0.12 sex, age at study enrollment, genetic PCs 1-20
PPM002957 PGS000908
(PRS_Insomnia)
PSS001290|
European Ancestry|
3,665 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Fluoxetine takers OR: 1.03 [0.94, 1.13] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002958 PGS000908
(PRS_Insomnia)
PSS001288|
European Ancestry|
1,994 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Duloxetine takers OR: 1.14 [1.02, 1.28] Variance explained (Nagelkerke's R2*100): 0.4 sex, age at study enrollment, genetic PCs 1-20
PPM002959 PGS000908
(PRS_Insomnia)
PSS001292|
European Ancestry|
1,577 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Paroxetine takers OR: 1.16 [1.01, 1.33] Variance explained (Nagelkerke's R2*100): 0.47 sex, age at study enrollment, genetic PCs 1-20
PPM010331 PGS001932
(portability-PLR_insomnia)
PSS009419|
European Ancestry|
19,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1248 [0.1111, 0.1384] sex, age, birth date, deprivation index, 16 PCs
PPM010332 PGS001932
(portability-PLR_insomnia)
PSS009193|
European Ancestry|
4,116 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1003 [0.0699, 0.1305] sex, age, birth date, deprivation index, 16 PCs
PPM010333 PGS001932
(portability-PLR_insomnia)
PSS008747|
European Ancestry|
6,626 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1093 [0.0854, 0.133] sex, age, birth date, deprivation index, 16 PCs
PPM010334 PGS001932
(portability-PLR_insomnia)
PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0776 [0.0195, 0.1353] sex, age, birth date, deprivation index, 16 PCs
PPM010335 PGS001932
(portability-PLR_insomnia)
PSS008299|
South Asian Ancestry|
6,199 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0768 [0.052, 0.1015] sex, age, birth date, deprivation index, 16 PCs
PPM010337 PGS001932
(portability-PLR_insomnia)
PSS007863|
African Ancestry|
2,460 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0475 [0.0078, 0.087] sex, age, birth date, deprivation index, 16 PCs
PPM010338 PGS001932
(portability-PLR_insomnia)
PSS008967|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.033 [0.0013, 0.0645] sex, age, birth date, deprivation index, 16 PCs
PPM010336 PGS001932
(portability-PLR_insomnia)
PSS008076|
East Asian Ancestry|
1,788 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0473 sex, age, birth date, deprivation index, 16 PCs
PPM012040 PGS002149
(portability-ldpred2_insomnia)
PSS009193|
European Ancestry|
4,116 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1208 [0.0905, 0.1508] sex, age, birth date, deprivation index, 16 PCs
PPM012039 PGS002149
(portability-ldpred2_insomnia)
PSS009419|
European Ancestry|
19,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1411 [0.1275, 0.1547] sex, age, birth date, deprivation index, 16 PCs
PPM012041 PGS002149
(portability-ldpred2_insomnia)
PSS008747|
European Ancestry|
6,626 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1253 [0.1015, 0.149] sex, age, birth date, deprivation index, 16 PCs
PPM012042 PGS002149
(portability-ldpred2_insomnia)
PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0852 [0.0271, 0.1427] sex, age, birth date, deprivation index, 16 PCs
PPM012043 PGS002149
(portability-ldpred2_insomnia)
PSS008299|
South Asian Ancestry|
6,199 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0985 [0.0737, 0.1231] sex, age, birth date, deprivation index, 16 PCs
PPM012044 PGS002149
(portability-ldpred2_insomnia)
PSS008076|
East Asian Ancestry|
1,788 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0345 [-0.0122, 0.081] sex, age, birth date, deprivation index, 16 PCs
PPM012045 PGS002149
(portability-ldpred2_insomnia)
PSS007863|
African Ancestry|
2,460 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0283 [-0.0114, 0.0679] sex, age, birth date, deprivation index, 16 PCs
PPM012046 PGS002149
(portability-ldpred2_insomnia)
PSS008967|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0314 sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001294
[
  • 793 cases
  • , 3,171 controls
]
European AGDS
PSS008967 3,863 individuals African unspecified Nigeria (West Africa) UKB
PSS009193 4,116 individuals European Poland (NE Europe) UKB
PSS008521 1,153 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009419 19,978 individuals European UK (+ Ireland) UKB
PSS008747 6,626 individuals European Italy (South Europe) UKB
PSS008299 6,199 individuals South Asian India (South Asia) UKB
PSS008076 1,788 individuals East Asian China (East Asia) UKB
PSS007863 2,460 individuals African American or Afro-Caribbean Carribean UKB
PSS001285
[
  • 140 cases
  • , 1,515 controls
]
European AGDS
PSS001286
[
  • 367 cases
  • , 2,218 controls
]
European AGDS
PSS001287
[
  • 488 cases
  • , 2,035 controls
]
European AGDS
PSS001288
[
  • 382 cases
  • , 1,612 controls
]
European AGDS
PSS001289
[
  • 712 cases
  • , 3,650 controls
]
European AGDS
PSS001290
[
  • 582 cases
  • , 3,083 controls
]
European AGDS
PSS001291
[
  • 186 cases
  • , 1,800 controls
]
European AGDS
PSS001292
[
  • 235 cases
  • , 1,342 controls
]
European AGDS
PSS001293
[
  • 1,018 cases
  • , 4,695 controls
]
European AGDS