Trait: lean body mass

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004995
Description The weight of all organs and tissue in an individual less the weight of the individual's body fat.
Trait category
Other measurement
Mapped terms 2 mapped terms
  • NCIt:C71258
  • SNOMEDCT:248362003

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001165
(GBE_INI23125)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Arm fat free mass (L) lean body mass 30,360
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001165/ScoringFiles/PGS001165.txt.gz
PGS001166
(GBE_INI23117)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Leg fat free mass (L) lean body mass 30,340
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001166/ScoringFiles/PGS001166.txt.gz
PGS001167
(GBE_INI23113)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Leg fat-free mass (R) lean body mass 32,046
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001167/ScoringFiles/PGS001167.txt.gz
PGS001168
(GBE_INI23129)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Trunk fat free mass lean body mass 34,749
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001168/ScoringFiles/PGS001168.txt.gz
PGS001169
(GBE_INI23101)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Whole body fat free mass lean body mass 34,486
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001169/ScoringFiles/PGS001169.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008545 PGS001165
(GBE_INI23125)
PSS005151|
African Ancestry|
6,299 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Arm fat-free mass (L) : 0.5894 [0.57408, 0.60472]
Incremental R2 (full-covars): 0.00951
PGS R2 (no covariates): 0.01764 [0.0113, 0.02399]
age, sex, UKB array type, Genotype PCs
PPM008546 PGS001165
(GBE_INI23125)
PSS005152|
East Asian Ancestry|
1,678 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Arm fat-free mass (L) : 0.74448 [0.72359, 0.76538]
Incremental R2 (full-covars): 0.0034
PGS R2 (no covariates): 0.01331 [0.00252, 0.0241]
age, sex, UKB array type, Genotype PCs
PPM008547 PGS001165
(GBE_INI23125)
PSS005153|
European Ancestry|
24,457 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Arm fat-free mass (L) : 0.73779 [0.7322, 0.74339]
Incremental R2 (full-covars): 0.03937
PGS R2 (no covariates): 0.0417 [0.03684, 0.04656]
age, sex, UKB array type, Genotype PCs
PPM008548 PGS001165
(GBE_INI23125)
PSS005154|
South Asian Ancestry|
7,647 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Arm fat-free mass (L) : 0.66424 [0.65212, 0.67635]
Incremental R2 (full-covars): 0.03058
PGS R2 (no covariates): 0.02351 [0.01688, 0.03014]
age, sex, UKB array type, Genotype PCs
PPM008549 PGS001165
(GBE_INI23125)
PSS005155|
European Ancestry|
66,234 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Arm fat-free mass (L) : 0.73264 [0.72918, 0.73609]
Incremental R2 (full-covars): 0.04461
PGS R2 (no covariates): 0.04544 [0.04237, 0.04851]
age, sex, UKB array type, Genotype PCs
PPM008550 PGS001166
(GBE_INI23117)
PSS005111|
African Ancestry|
6,303 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (L) : 0.53187 [0.51528, 0.54846]
Incremental R2 (full-covars): 0.00841
PGS R2 (no covariates): 0.0152 [0.0093, 0.0211]
age, sex, UKB array type, Genotype PCs
PPM008551 PGS001166
(GBE_INI23117)
PSS005112|
East Asian Ancestry|
1,679 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (L) : 0.72443 [0.7022, 0.74666]
Incremental R2 (full-covars): 0.00342
PGS R2 (no covariates): 0.01608 [0.00425, 0.0279]
age, sex, UKB array type, Genotype PCs
PPM008552 PGS001166
(GBE_INI23117)
PSS005113|
European Ancestry|
24,461 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (L) : 0.7007 [0.69448, 0.70692]
Incremental R2 (full-covars): 0.0443
PGS R2 (no covariates): 0.0464 [0.0413, 0.0515]
age, sex, UKB array type, Genotype PCs
PPM008553 PGS001166
(GBE_INI23117)
PSS005114|
South Asian Ancestry|
7,649 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (L) : 0.65024 [0.63775, 0.66272]
Incremental R2 (full-covars): 0.03375
PGS R2 (no covariates): 0.0265 [0.01948, 0.03352]
age, sex, UKB array type, Genotype PCs
PPM008554 PGS001166
(GBE_INI23117)
PSS005115|
European Ancestry|
66,253 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (L) : 0.69394 [0.69009, 0.69779]
Incremental R2 (full-covars): 0.05093
PGS R2 (no covariates): 0.05064 [0.04742, 0.05387]
age, sex, UKB array type, Genotype PCs
PPM008555 PGS001167
(GBE_INI23113)
PSS005096|
African Ancestry|
6,305 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (R) : 0.53747 [0.52099, 0.55395]
Incremental R2 (full-covars): 0.00943
PGS R2 (no covariates): 0.01562 [0.00964, 0.0216]
age, sex, UKB array type, Genotype PCs
PPM008556 PGS001167
(GBE_INI23113)
PSS005097|
East Asian Ancestry|
1,680 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (R) : 0.72975 [0.70788, 0.75163]
Incremental R2 (full-covars): 0.00171
PGS R2 (no covariates): 0.01431 [0.00314, 0.02549]
age, sex, UKB array type, Genotype PCs
PPM008557 PGS001167
(GBE_INI23113)
PSS005098|
European Ancestry|
24,461 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (R) : 0.70588 [0.69974, 0.71201]
Incremental R2 (full-covars): 0.04477
PGS R2 (no covariates): 0.0455 [0.04045, 0.05056]
age, sex, UKB array type, Genotype PCs
PPM008558 PGS001167
(GBE_INI23113)
PSS005099|
South Asian Ancestry|
7,649 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (R) : 0.65682 [0.64451, 0.66914]
Incremental R2 (full-covars): 0.03381
PGS R2 (no covariates): 0.02711 [0.02002, 0.0342]
age, sex, UKB array type, Genotype PCs
PPM008559 PGS001167
(GBE_INI23113)
PSS005100|
European Ancestry|
66,257 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Leg fat-free mass (R) : 0.69994 [0.69615, 0.70373]
Incremental R2 (full-covars): 0.05103
PGS R2 (no covariates): 0.04961 [0.04641, 0.0528]
age, sex, UKB array type, Genotype PCs
PPM008560 PGS001168
(GBE_INI23129)
PSS005171|
African Ancestry|
6,298 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Trunk fat-free mass : 0.59642 [0.58127, 0.61157]
Incremental R2 (full-covars): 0.01057
PGS R2 (no covariates): 0.0178 [0.01143, 0.02418]
age, sex, UKB array type, Genotype PCs
PPM008561 PGS001168
(GBE_INI23129)
PSS005172|
East Asian Ancestry|
1,677 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Trunk fat-free mass : 0.73696 [0.71556, 0.75835]
Incremental R2 (full-covars): 0.01146
PGS R2 (no covariates): 0.0221 [0.00833, 0.03588]
age, sex, UKB array type, Genotype PCs
PPM008562 PGS001168
(GBE_INI23129)
PSS005173|
European Ancestry|
24,445 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Trunk fat-free mass : 0.76298 [0.75784, 0.76812]
Incremental R2 (full-covars): 0.04792
PGS R2 (no covariates): 0.04719 [0.04205, 0.05233]
age, sex, UKB array type, Genotype PCs
PPM008563 PGS001168
(GBE_INI23129)
PSS005174|
South Asian Ancestry|
7,645 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Trunk fat-free mass : 0.69077 [0.67939, 0.70215]
Incremental R2 (full-covars): 0.03748
PGS R2 (no covariates): 0.03123 [0.02365, 0.03881]
age, sex, UKB array type, Genotype PCs
PPM008564 PGS001168
(GBE_INI23129)
PSS005175|
European Ancestry|
66,210 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Trunk fat-free mass : 0.76832 [0.76525, 0.77138]
Incremental R2 (full-covars): 0.05259
PGS R2 (no covariates): 0.05253 [0.04925, 0.05581]
age, sex, UKB array type, Genotype PCs
PPM008565 PGS001169
(GBE_INI23101)
PSS005046|
African Ancestry|
6,304 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Whole body fat-free mass : 0.60157 [0.58655, 0.61659]
Incremental R2 (full-covars): 0.01013
PGS R2 (no covariates): 0.01873 [0.0122, 0.02526]
age, sex, UKB array type, Genotype PCs
PPM008566 PGS001169
(GBE_INI23101)
PSS005047|
East Asian Ancestry|
1,680 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Whole body fat-free mass : 0.75252 [0.73217, 0.77286]
Incremental R2 (full-covars): 0.00794
PGS R2 (no covariates): 0.01884 [0.00608, 0.03161]
age, sex, UKB array type, Genotype PCs
PPM008567 PGS001169
(GBE_INI23101)
PSS005048|
European Ancestry|
24,463 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Whole body fat-free mass : 0.75918 [0.75397, 0.76439]
Incremental R2 (full-covars): 0.04637
PGS R2 (no covariates): 0.04707 [0.04193, 0.0522]
age, sex, UKB array type, Genotype PCs
PPM008568 PGS001169
(GBE_INI23101)
PSS005049|
South Asian Ancestry|
7,649 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Whole body fat-free mass : 0.69559 [0.68435, 0.70683]
Incremental R2 (full-covars): 0.03597
PGS R2 (no covariates): 0.02818 [0.02096, 0.03541]
age, sex, UKB array type, Genotype PCs
PPM008569 PGS001169
(GBE_INI23101)
PSS005050|
European Ancestry|
66,262 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Whole body fat-free mass : 0.76094 [0.75779, 0.76409]
Incremental R2 (full-covars): 0.05193
PGS R2 (no covariates): 0.05222 [0.04895, 0.05548]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005046 6,304 individuals African unspecified UKB
PSS005047 1,680 individuals East Asian UKB
PSS005096 6,305 individuals African unspecified UKB
PSS005097 1,680 individuals East Asian UKB
PSS005098 24,461 individuals European non-white British ancestry UKB
PSS005099 7,649 individuals South Asian UKB
PSS005100 66,257 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS005111 6,303 individuals African unspecified UKB
PSS005112 1,679 individuals East Asian UKB
PSS005113 24,461 individuals European non-white British ancestry UKB
PSS005114 7,649 individuals South Asian UKB
PSS005115 66,253 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS005151 6,299 individuals African unspecified UKB
PSS005152 1,678 individuals East Asian UKB
PSS005153 24,457 individuals European non-white British ancestry UKB
PSS005154 7,647 individuals South Asian UKB
PSS005155 66,234 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS005171 6,298 individuals African unspecified UKB
PSS005172 1,677 individuals East Asian UKB
PSS005173 24,445 individuals European non-white British ancestry UKB
PSS005174 7,645 individuals South Asian UKB
PSS005175 66,210 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS005048 24,463 individuals European non-white British ancestry UKB
PSS005049 7,649 individuals South Asian UKB
PSS005050 66,262 individuals European white British ancestry UKB Testing cohort (heldout set)