Trait: QRS duration

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005055
Description QRS duration is a measurement of the combined duration of the Q, R and S waves of the human heart's electric cycle
Trait category
Cardiovascular measurement
Synonym QRS interval

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000736
(PRS_QRS)
 PGP000144 |
Tadros R et al. Eur Heart J (2019)
 QRS duration QRS duration 26
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000736/ScoringFiles/PGS000736.txt.gz
PGS001525
(GBE_INI12340)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 QRS duration QRS duration 401
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001525/ScoringFiles/PGS001525.txt.gz
PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 QRS duration QRS duration 1,967
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001948/ScoringFiles/PGS001948.txt.gz
PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 QRS duration QRS duration 471,172
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002166/ScoringFiles/PGS002166.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001760 PGS000736
(PRS_QRS)
 PSS000905|
European Ancestry|
1,185 individuals
 PGP000144 |
Tadros R et al. Eur Heart J (2019)
 Reported Trait: Ajmaline-induced Type I Brugada syndrome electrocardiogram OR: 1.047 [1.031, 1.063] — — — —
PPM001753 PGS000736
(PRS_QRS)
 PSS000906|
European Ancestry|
1,193 individuals
 PGP000144 |
Tadros R et al. Eur Heart J (2019)
 Reported Trait: QRS slope in non SCN5A mutation carriers β: 0.93 (0.2) — Correlation coefficient (r): 0.14 — —
PPM001751 PGS000736
(PRS_QRS)
 PSS000906|
European Ancestry|
1,193 individuals
 PGP000144 |
Tadros R et al. Eur Heart J (2019)
 Reported Trait: Baseline QRS in non SCN5A mutation carriers — — Correlation coefficent (r): 0.15 — —
PPM001755 PGS000736
(PRS_QRS)
 PSS000904|
European Ancestry|
1,257 individuals
 PGP000144 |
Tadros R et al. Eur Heart J (2019)
 Reported Trait: QRS slope β: 0.8 (0.22) — — — —
PPM001756 PGS000736
(PRS_QRS)
 PSS000903|
European Ancestry|
295 individuals
 PGP000144 |
Tadros R et al. Eur Heart J (2019)
 Reported Trait: QRS slope β: 0.8 (0.22) — — Age, SCN5A mutation —
PPM005235 PGS001525
(GBE_INI12340)
 PSS004806|
African Ancestry|
203 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: QRS duration — — R²: 0.20692 [0.18939, 0.22446]
Incremental R2 (full-covars): 0.01284
PGS R2 (no covariates): 0.02209 [0.01502, 0.02915]		 age, sex, UKB array type, Genotype PCs —
PPM005236 PGS001525
(GBE_INI12340)
 PSS004807|
East Asian Ancestry|
102 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: QRS duration — — R²: 0.199 [0.16514, 0.23286]
Incremental R2 (full-covars): 0.01328
PGS R2 (no covariates): 0.00454 [-0.00181, 0.0109]		 age, sex, UKB array type, Genotype PCs —
PPM005237 PGS001525
(GBE_INI12340)
 PSS004808|
European Ancestry|
1,601 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: QRS duration — — R²: 0.1428 [0.13475, 0.15084]
Incremental R2 (full-covars): 0.02153
PGS R2 (no covariates): 0.01977 [0.01635, 0.02319]		 age, sex, UKB array type, Genotype PCs —
PPM005238 PGS001525
(GBE_INI12340)
 PSS004809|
South Asian Ancestry|
315 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: QRS duration — — R²: 0.20988 [0.19385, 0.2259]
Incremental R2 (full-covars): 0.00738
PGS R2 (no covariates): 0.00578 [0.00243, 0.00912]		 age, sex, UKB array type, Genotype PCs —
PPM005239 PGS001525
(GBE_INI12340)
 PSS004810|
European Ancestry|
5,223 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: QRS duration — — R²: 0.11697 [0.11241, 0.12153]
Incremental R2 (full-covars): 0.01872
PGS R2 (no covariates): 0.02164 [0.01947, 0.02382]		 age, sex, UKB array type, Genotype PCs —
PPM010461 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS008759|
European Ancestry|
487 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2468 [0.1596, 0.3301] sex, age, birth date, deprivation index, 16 PCs —
PPM010459 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS009431|
European Ancestry|
1,702 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2202 [0.1743, 0.2652] sex, age, birth date, deprivation index, 16 PCs —
PPM010462 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS008533|
Greater Middle Eastern Ancestry|
50 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.1933 [-0.1794, 0.5176] sex, age, birth date, deprivation index, 16 PCs —
PPM010463 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS008311|
South Asian Ancestry|
305 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2407 [0.1281, 0.3472] sex, age, birth date, deprivation index, 16 PCs —
PPM010464 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS008088|
East Asian Ancestry|
137 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.0168 [-0.1652, 0.1978] sex, age, birth date, deprivation index, 16 PCs —
PPM010465 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS007875|
African Ancestry|
77 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.155 [-0.11, 0.3995] sex, age, birth date, deprivation index, 16 PCs —
PPM010466 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS008979|
African Ancestry|
140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.0017 [-0.1776, 0.1809] sex, age, birth date, deprivation index, 16 PCs —
PPM010460 PGS001948
(portability-PLR_log_ECG_QRS_duration)
 PSS009205|
European Ancestry|
329 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.1602 [0.0495, 0.267] sex, age, birth date, deprivation index, 16 PCs —
PPM012175 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS009431|
European Ancestry|
1,702 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2257 [0.1798, 0.2706] sex, age, birth date, deprivation index, 16 PCs —
PPM012176 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS009205|
European Ancestry|
329 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.1797 [0.0695, 0.2855] sex, age, birth date, deprivation index, 16 PCs —
PPM012177 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS008759|
European Ancestry|
487 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2307 [0.143, 0.3149] sex, age, birth date, deprivation index, 16 PCs —
PPM012178 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS008533|
Greater Middle Eastern Ancestry|
50 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2134 [-0.1591, 0.5327] sex, age, birth date, deprivation index, 16 PCs —
PPM012179 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS008311|
South Asian Ancestry|
305 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2354 [0.1226, 0.3422] sex, age, birth date, deprivation index, 16 PCs —
PPM012180 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS008088|
East Asian Ancestry|
137 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.0367 [-0.1458, 0.2168] sex, age, birth date, deprivation index, 16 PCs —
PPM012181 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS007875|
African Ancestry|
77 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.1029 [-0.162, 0.354] sex, age, birth date, deprivation index, 16 PCs —
PPM012182 PGS002166
(portability-ldpred2_log_ECG_QRS_duration)
 PSS008979|
African Ancestry|
140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.0257 [-0.1542, 0.204] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004806 — — 203 individuals — African unspecified — UKB —
PSS004807 — — 102 individuals — East Asian — UKB —
PSS004808 — — 1,601 individuals — European non-white British ancestry UKB —
PSS004809 — — 315 individuals — South Asian — UKB —
PSS004810 — — 5,223 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS008979 — — 140 individuals — African unspecified Nigeria (West Africa) UKB —
PSS000903 Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.14 — 295 individuals — European — Amsterdam —
PSS000904 Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.12 — 1,257 individuals — European — Amsterdam —
PSS000905 Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.15 — 1,185 individuals — European — Amsterdam —
PSS000906 Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.13 — 1,193 individuals — European — Amsterdam —
PSS008759 — — 487 individuals — European Italy (South Europe) UKB —
PSS009431 — — 1,702 individuals — European UK (+ Ireland) UKB —
PSS008533 — — 50 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008311 — — 305 individuals — South Asian India (South Asia) UKB —
PSS008088 — — 137 individuals — East Asian China (East Asia) UKB —
PSS009205 — — 329 individuals — European Poland (NE Europe) UKB —
PSS007875 — — 77 individuals — African American or Afro-Caribbean Carribean UKB —