Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0005782 |
Description | Age-related hearing impairment is characterized by a symmetric sensorineural hearing loss that is most pronounced in the high frequencies. Age of onset, progression, and severity of age-related hearing impairment (ARHI) show great variation in the population, but with a demonstrable increased prevalence in males. [EFO: 0005782] | Trait category |
Neurological disorder
|
Synonyms |
3 synonyms
|
Mapped terms |
2 mapped terms
|
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | Ancestry distribution | Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000762 (PRS_HD) |
PGP000165 | Cherny SS et al. Eur J Hum Genet (2020) |
Hearing difficulties | age-related hearing impairment | 100,325 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000762/ScoringFiles/PGS000762.txt.gz |
PGS000763 (PRS_HAID) |
PGP000165 | Cherny SS et al. Eur J Hum Genet (2020) |
Hearing aid use | age-related hearing impairment | 4,270 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000763/ScoringFiles/PGS000763.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001938 | PGS000762 (PRS_HD) |
PSS000972| European Ancestry| 3,636 individuals |
PGP000165 | Cherny SS et al. Eur J Hum Genet (2020) |
Reported Trait: Hearing difficulties | — | — | R²: 0.0911 | Age, sex | — |
PPM001937 | PGS000763 (PRS_HAID) |
PSS000971| European Ancestry| 2,912 individuals |
PGP000165 | Cherny SS et al. Eur J Hum Genet (2020) |
Reported Trait: Hearing aid use | — | — | R²: 0.1923 | Age, sex | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000972 | Hearing difficulty cases were defined as responding either ‘Yes, diagnosed by doctor or health professional’ or ‘Yes, not diagnosed by health professional’ to ‘Do you suffer from hearing loss?’ while participants that responded ‘No’ were assigned as controls. | — | [ ,
8.5 % Male samples |
Mean = 60.34 years Sd = 10.18 years |
European (British) |
— | TwinsUK | — |
PSS000971 | Hearing aid use cases responded ‘Yes’ to either ‘Do you wear a hearing aid?’ or ‘Wearing a hearing aid’ while controls responded ‘No’. | — | [ ,
8.0 % Male samples |
Mean = 59.32 years Sd = 9.69 years |
European (British) |
— | TwinsUK | — |