Trait: Cannabis use

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007585
Description The consumption of the recreational drug cannabis (also known as marijuna and a number of other colloquial names). Cannabis use is illegal in some countries but not in others.
Trait category
Biological process
Synonyms 2 synonyms
  • Cannabis consumption
  • Cannabis use behaviour
Mapped term MedDRA:10070996

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001391
(GBE_INI20453)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Ever taken cannabis Cannabis use 819
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001391/ScoringFiles/PGS001391.txt.gz
PGS001910
(portability-PLR_ever_cannabis)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Ever taken cannabis Cannabis use 9,341
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001910/ScoringFiles/PGS001910.txt.gz
PGS002125
(portability-ldpred2_ever_cannabis)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Ever taken cannabis Cannabis use 816,604
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002125/ScoringFiles/PGS002125.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005255 PGS001391
(GBE_INI20453)
PSS004906|
African Ancestry|
915 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ever taken cannabis : 0.08388 [0.07099, 0.09678]
Incremental R2 (full-covars): -0.0006
PGS R2 (no covariates): 0.00037 [-0.00056, 0.0013]
age, sex, UKB array type, Genotype PCs
PPM005256 PGS001391
(GBE_INI20453)
PSS004907|
East Asian Ancestry|
362 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ever taken cannabis : 0.02498 [0.01038, 0.03959]
Incremental R2 (full-covars): -0.00599
PGS R2 (no covariates): 0.00101 [-0.002, 0.00401]
age, sex, UKB array type, Genotype PCs
PPM005257 PGS001391
(GBE_INI20453)
PSS004908|
European Ancestry|
8,139 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ever taken cannabis : 0.08763 [0.08092, 0.09434]
Incremental R2 (full-covars): 0.00226
PGS R2 (no covariates): 0.00384 [0.00231, 0.00537]
age, sex, UKB array type, Genotype PCs
PPM005258 PGS001391
(GBE_INI20453)
PSS004909|
South Asian Ancestry|
1,047 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ever taken cannabis : 0.04702 [0.03787, 0.05616]
Incremental R2 (full-covars): -0.00092
PGS R2 (no covariates): 0.00033 [-0.00048, 0.00114]
age, sex, UKB array type, Genotype PCs
PPM005259 PGS001391
(GBE_INI20453)
PSS004910|
European Ancestry|
22,015 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ever taken cannabis : 0.06878 [0.06509, 0.07247]
Incremental R2 (full-covars): 0.00123
PGS R2 (no covariates): 0.00117 [0.00065, 0.00169]
age, sex, UKB array type, Genotype PCs
PPM010163 PGS001910
(portability-PLR_ever_cannabis)
PSS009402|
European Ancestry|
5,865 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.071 [0.0455, 0.0965] sex, age, birth date, deprivation index, 16 PCs
PPM010164 PGS001910
(portability-PLR_ever_cannabis)
PSS009176|
European Ancestry|
1,104 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0914 [0.0321, 0.1502] sex, age, birth date, deprivation index, 16 PCs
PPM010165 PGS001910
(portability-PLR_ever_cannabis)
PSS008730|
European Ancestry|
2,006 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0329 [-0.0111, 0.0768] sex, age, birth date, deprivation index, 16 PCs
PPM010166 PGS001910
(portability-PLR_ever_cannabis)
PSS008504|
Greater Middle Eastern Ancestry|
186 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0068 [-0.1456, 0.159] sex, age, birth date, deprivation index, 16 PCs
PPM010167 PGS001910
(portability-PLR_ever_cannabis)
PSS008282|
South Asian Ancestry|
784 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0078 [-0.0787, 0.0631] sex, age, birth date, deprivation index, 16 PCs
PPM010169 PGS001910
(portability-PLR_ever_cannabis)
PSS007846|
African Ancestry|
333 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0465 [-0.0647, 0.1565] sex, age, birth date, deprivation index, 16 PCs
PPM010170 PGS001910
(portability-PLR_ever_cannabis)
PSS008950|
African Ancestry|
482 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0235 [-0.1145, 0.0679] sex, age, birth date, deprivation index, 16 PCs
PPM010168 PGS001910
(portability-PLR_ever_cannabis)
PSS008059|
East Asian Ancestry|
405 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0454 [-0.1447, 0.0548] sex, age, birth date, deprivation index, 16 PCs
PPM011855 PGS002125
(portability-ldpred2_ever_cannabis)
PSS009402|
European Ancestry|
5,865 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0878 [0.0623, 0.1131] sex, age, birth date, deprivation index, 16 PCs
PPM011856 PGS002125
(portability-ldpred2_ever_cannabis)
PSS009176|
European Ancestry|
1,104 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0861 [0.0267, 0.1449] sex, age, birth date, deprivation index, 16 PCs
PPM011857 PGS002125
(portability-ldpred2_ever_cannabis)
PSS008730|
European Ancestry|
2,006 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0935 [0.0497, 0.1369] sex, age, birth date, deprivation index, 16 PCs
PPM011858 PGS002125
(portability-ldpred2_ever_cannabis)
PSS008504|
Greater Middle Eastern Ancestry|
186 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0343 [-0.1186, 0.1857] sex, age, birth date, deprivation index, 16 PCs
PPM011859 PGS002125
(portability-ldpred2_ever_cannabis)
PSS008282|
South Asian Ancestry|
784 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0754 [0.0045, 0.1455] sex, age, birth date, deprivation index, 16 PCs
PPM011860 PGS002125
(portability-ldpred2_ever_cannabis)
PSS008059|
East Asian Ancestry|
405 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): -0.0487 [-0.1479, 0.0515] sex, age, birth date, deprivation index, 16 PCs
PPM011861 PGS002125
(portability-ldpred2_ever_cannabis)
PSS007846|
African Ancestry|
333 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0181 [-0.0929, 0.1287] sex, age, birth date, deprivation index, 16 PCs
PPM011862 PGS002125
(portability-ldpred2_ever_cannabis)
PSS008950|
African Ancestry|
482 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever taken cannabis Partial Correlation (partial-r): 0.0517 [-0.0398, 0.1422] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007846 333 individuals African American or Afro-Caribbean Carribean UKB
PSS004906 915 individuals African unspecified UKB
PSS004907 362 individuals East Asian UKB
PSS004908 8,139 individuals European non-white British ancestry UKB
PSS004909 1,047 individuals South Asian UKB
PSS004910 22,015 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS008950 482 individuals African unspecified Nigeria (West Africa) UKB
PSS009176 1,104 individuals European Poland (NE Europe) UKB
PSS008504 186 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009402 5,865 individuals European UK (+ Ireland) UKB
PSS008730 2,006 individuals European Italy (South Europe) UKB
PSS008282 784 individuals South Asian India (South Asia) UKB
PSS008059 405 individuals East Asian China (East Asia) UKB