Trait: urinary albumin to creatinine ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007778
Description
  • quantification of the ratio of albumin to creatinine in a urine sample
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000822
(GRS_UACR)
PGP000206 |
Teumer A et al. Nat Commun (2019)
Urinary albumin to creatinine ratio urinary albumin to creatinine ratio 59
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000822/ScoringFiles/PGS000822.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002203 PGS000822
(GRS_UACR)
PSS001079|
European Ancestry|
232,751 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Microalbuminuria Odds Ratio (OR, top 25% vs bottom 25%): 1.69 [1.64, 1.75]
Beta (top 25% vs bottom 25%): 0.527 (0.018)
PPM002204 PGS000822
(GRS_UACR)
PSS001074|
European Ancestry|
182,870 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Disorders of lipid metabolism OR: 1.58
β: 0.46 (0.07)
PCs(1-10), sex
PPM002206 PGS000822
(GRS_UACR)
PSS001074|
European Ancestry|
182,870 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Mixed hyperlipidemia OR: 1.69
β: 0.53 (0.11)
PCs(1-10), sex
PPM002207 PGS000822
(GRS_UACR)
PSS001078|
European Ancestry|
121,142 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Fuchs' dystrophy OR: 6.68 [3.06, 14.59]
β: 1.9 (0.4)
PCs(1-10), sex
PPM002208 PGS000822
(GRS_UACR)
PSS001073|
European Ancestry|
182,884 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Hypertension OR: 1.38
β: 0.32 (0.07)
PCs(1-10), sex
PPM002209 PGS000822
(GRS_UACR)
PSS001073|
European Ancestry|
182,884 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Essential hypertension OR: 1.37
β: 0.32 (0.07)
PCs(1-10), sex
PPM002210 PGS000822
(GRS_UACR)
PSS001077|
European Ancestry|
186,343 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Proteinuria OR: 2.7 [1.76, 4.14]
β: 0.99 (0.22)
PCs(1-10), sex
PPM002212 PGS000822
(GRS_UACR)
PSS001075|
European Ancestry|
188,088 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Gout and other crystal arthropathies OR: 1.58
β: 0.46 (0.1)
PCs(1-10), sex
PPM002213 PGS000822
(GRS_UACR)
PSS001076|
European Ancestry|
73,407 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Hypercholesterolemia OR: 1.47
β: 0.39 (0.09)
PCs(1-10), sex
PPM002205 PGS000822
(GRS_UACR)
PSS001074|
European Ancestry|
182,870 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Hyperlipidemia OR: 1.58
β: 0.46 (0.07)
PCs(1-10), sex
PPM002211 PGS000822
(GRS_UACR)
PSS001075|
European Ancestry|
188,088 individuals
PGP000206 |
Teumer A et al. Nat Commun (2019)
Reported Trait: Gout OR: 1.6
β: 0.47 (0.1)
PCs(1-10), sex

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001073 Cases were individuals with hypertension. Of the 136,370 cases, 136,053 had essential hypertension.
[
  • 136,370 cases
  • , 46,514 controls
]
European MVP
PSS001074 Cases were individuals with disorders of lipid metabolism. Of the 141,461 cases, 141,331 had hyperlipidemia and 19,150 had mixed hyperlipidemia.
[
  • 141,461 cases
  • , 41,409 controls
]
European MVP
PSS001075 Cases were individuals with gout and other crystal arthropathies. Of the 15,484 cases, 15,011 specifically, had gout.
[
  • 15,484 cases
  • , 172,524 controls
]
European MVP
PSS001076 Cases were individuals with hypercholesterolemia.
[
  • 31,998 cases
  • , 41,409 controls
]
European MVP
PSS001077 Cases were individuals with proteinuria.
[
  • 3,122 cases
  • , 183,221 controls
]
European MVP
PSS001078 Cases were individuals with Fuchs' disease.
[
  • 874 cases
  • , 120,268 controls
]
European MVP
PSS001079 Cases were individuals with microalbuminuria (MA). MA was defined by a urinary albumin to creatinine ratio (UACR) > 30 mg/g.
[
  • 30,014 cases
  • , 202,737 controls
]
European UKB Possible sample overlap (up to 41%) between this dataset and the dataset used to source GRS_UACR.