Trait: apolipoprotein A-IV measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007848
Description quantification of serum lipoprotein A-IV. Apolipoprotein A-IV, encoded in humans by the APOA4 gene, a 376-residue mature O-linked glycoprotein.
Trait category
Lipid or lipoprotein measurement
Synonym lipoprotein A-IV levels

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003491
(cont-decay-apoA)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Apolipoprotein A apolipoprotein A-IV measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003491/ScoringFiles/PGS003491.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017419 PGS003491
(cont-decay-apoA)
 PSS010870|
European Ancestry|
17,435 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017503 PGS003491
(cont-decay-apoA)
 PSS010786|
European Ancestry|
3,551 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017587 PGS003491
(cont-decay-apoA)
 PSS010618|
European Ancestry|
5,626 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017671 PGS003491
(cont-decay-apoA)
 PSS010534|
Greater Middle Eastern Ancestry|
1,004 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017755 PGS003491
(cont-decay-apoA)
 PSS010198|
European Ancestry|
2,045 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017839 PGS003491
(cont-decay-apoA)
 PSS010450|
South Asian Ancestry|
5,419 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.13 sex, age, deprivation index, PC1-16 —
PPM017923 PGS003491
(cont-decay-apoA)
 PSS010366|
East Asian Ancestry|
1,533 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM018007 PGS003491
(cont-decay-apoA)
 PSS010282|
African Ancestry|
2,140 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM018091 PGS003491
(cont-decay-apoA)
 PSS010702|
African Ancestry|
3,363 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Apolipoprotein A — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010366 — — 1,533 individuals,
34.0 % Male samples
 Mean = 52.4 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS010786 — — 3,551 individuals,
39.0 % Male samples
 Mean = 54.4 years
Sd = 7.6 years		 European Polish UKB —
PSS010534 — — 1,004 individuals,
60.0 % Male samples
 Mean = 51.9 years
Sd = 7.9 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010282 — — 2,140 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010702 — — 3,363 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010450 — — 5,419 individuals,
55.0 % Male samples
 Mean = 53.2 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010870 — — 17,435 individuals,
47.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010198 — — 2,045 individuals,
46.0 % Male samples
 Mean = 58.0 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS010618 — — 5,626 individuals,
46.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —