Trait: creatinine clearance measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007934
Description
  • The clearance rate of creatinine, that is, the volume of plasma that is cleared of creatinine by the kidneys per unit time. Creatinine clearance is calculated using the level of creatinine in a sample of urine, usually one collected over a period of 24 hours, the corresponding plasma creatinine level, and the volume of urine excreted. It is used as an approximation of the glomerular filtration rate (GFR).
Trait category
Other measurement
Mapped term(s) CMO:0000765

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000679
(snpnet.Creatinine_in_urine)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Creatinine in urine [umol/L] creatinine clearance measurement 5,469
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000679/ScoringFiles/PGS000679.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001512 PGS000679
(snpnet.Creatinine_in_urine)
PSS000672|
South Asian Ancestry|
7,009 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine in urine [umol/L] : 0.16585
Spearman's ρ: 0.056
Age, sex, PCs(1-40)
PPM001547 PGS000679
(snpnet.Creatinine_in_urine)
PSS000673|
European Ancestry|
62,142 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine in urine [umol/L] : 0.14919
Spearman's ρ: 0.077
Age, sex, PCs(1-40)
PPM001477 PGS000679
(snpnet.Creatinine_in_urine)
PSS000671|
European Ancestry|
22,875 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine in urine [umol/L] : 0.16134
Spearman's ρ: 0.068
Age, sex, PCs(1-40)
PPM001442 PGS000679
(snpnet.Creatinine_in_urine)
PSS000670|
East Asian Ancestry|
1,045 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine in urine [umol/L] : 0.16547
Spearman's ρ: 0.049
Age, sex, PCs(1-40)
PPM001407 PGS000679
(snpnet.Creatinine_in_urine)
PSS000669|
African Ancestry|
5,789 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Creatinine in urine [umol/L] : 0.11165
Spearman's ρ: 0.035
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000669 5,789 individuals African unspecified UKB
PSS000670 1,045 individuals East Asian UKB
PSS000671 22,875 individuals European Non-British White UKB
PSS000672 7,009 individuals South Asian UKB
PSS000673 62,142 individuals European
(British)
UKB