Trait: hippocampal CA4 volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009396
Description Volume of hippocampal CA4.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003633
(L_CA4_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 head volume hippocampal CA4 volume 22,605
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003633/ScoringFiles/PGS003633.txt.gz
PGS003634
(L_CA4_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 body volume hippocampal CA4 volume 375
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003634/ScoringFiles/PGS003634.txt.gz
PGS003635
(R_CA4_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA4 head volume hippocampal CA4 volume 12,506
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003635/ScoringFiles/PGS003635.txt.gz
PGS003636
(R_CA4_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA4 body volume hippocampal CA4 volume 3,322
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003636/ScoringFiles/PGS003636.txt.gz
PGS003637
(L_CA4_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 head volume hippocampal CA4 volume 84,284
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003637/ScoringFiles/PGS003637.txt.gz
PGS003638
(L_CA4_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 body volume hippocampal CA4 volume 894
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003638/ScoringFiles/PGS003638.txt.gz
PGS003639
(R_CA4_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA4 head volume hippocampal CA4 volume 3,200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003639/ScoringFiles/PGS003639.txt.gz
PGS003640
(R_CA4_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA4 body volume hippocampal CA4 volume 497
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003640/ScoringFiles/PGS003640.txt.gz
PGS003641
(L_CA4_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 head volume hippocampal CA4 volume 48
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003641/ScoringFiles/PGS003641.txt.gz
PGS003642
(L_CA4_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA4 body volume hippocampal CA4 volume 3,644
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003642/ScoringFiles/PGS003642.txt.gz
PGS003643
(R_CA4_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA4 head volume hippocampal CA4 volume 73,791
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003643/ScoringFiles/PGS003643.txt.gz
PGS003644
(R_CA4_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA4 body volume hippocampal CA4 volume 10,113
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003644/ScoringFiles/PGS003644.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018301 PGS003633
(L_CA4_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA4 head volume — — R²: 0.01738 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018302 PGS003634
(L_CA4_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA4 body volume — — R²: 0.01659 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018322 PGS003635
(R_CA4_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA4 head volume — — R²: 0.00944 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018323 PGS003636
(R_CA4_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA4 body volume — — R²: 0.01436 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018345 PGS003637
(L_CA4_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA4 head volume — — R²: 0.00534 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018346 PGS003638
(L_CA4_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA4 body volume — — R²: 0.00901 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018366 PGS003639
(R_CA4_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA4 head volume — — R²: 0.00383 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018367 PGS003640
(R_CA4_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA4 body volume — — R²: 0.0079 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018389 PGS003641
(L_CA4_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA4 head volume — — R²: 0.00336 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018390 PGS003642
(L_CA4_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA4 body volume — — R²: 0.01072 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018410 PGS003643
(R_CA4_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA4 head volume — — R²: 0.00344 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018411 PGS003644
(R_CA4_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA4 body volume — — R²: 0.01166 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010958 — — 1,999 individuals — East Asian — CHIMGEN —