Trait: hippocampus molecular layer volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009397
Description Volume of hippocampus molecular layer.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003681
(L_molecular_layer_HP_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left molecular layer hippocampus proper head volume hippocampus molecular layer volume 6,707
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003681/ScoringFiles/PGS003681.txt.gz
PGS003682
(L_molecular_layer_HP_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left molecular layer hippocampus proper body volume hippocampus molecular layer volume 75,245
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003682/ScoringFiles/PGS003682.txt.gz
PGS003683
(R_molecular_layer_HP_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right molecular layer hippocampus proper head volume hippocampus molecular layer volume 14,560
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003683/ScoringFiles/PGS003683.txt.gz
PGS003684
(R_molecular_layer_HP_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right molecular layer hippocampus proper body volume hippocampus molecular layer volume 5,578
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003684/ScoringFiles/PGS003684.txt.gz
PGS003685
(L_molecular_layer_HP_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left molecular layer hippocampus proper head volume hippocampus molecular layer volume 17,451
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003685/ScoringFiles/PGS003685.txt.gz
PGS003686
(L_molecular_layer_HP_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left molecular layer hippocampus proper body volume hippocampus molecular layer volume 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003686/ScoringFiles/PGS003686.txt.gz
PGS003687
(R_molecular_layer_HP_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right molecular layer hippocampus proper head volume hippocampus molecular layer volume 2,371
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003687/ScoringFiles/PGS003687.txt.gz
PGS003688
(R_molecular_layer_HP_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right molecular layer hippocampus proper body volume hippocampus molecular layer volume 1,889
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003688/ScoringFiles/PGS003688.txt.gz
PGS003689
(L_molecular_layer_HP_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left molecular layer hippocampus proper head volume hippocampus molecular layer volume 23,227
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003689/ScoringFiles/PGS003689.txt.gz
PGS003690
(L_molecular_layer_HP_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left molecular layer hippocampus proper body volume hippocampus molecular layer volume 3,763
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003690/ScoringFiles/PGS003690.txt.gz
PGS003691
(R_molecular_layer_HP_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right molecular layer hippocampus proper head volume hippocampus molecular layer volume 20,460
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003691/ScoringFiles/PGS003691.txt.gz
PGS003692
(R_molecular_layer_HP_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right molecular layer hippocampus proper body volume hippocampus molecular layer volume 52,329
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003692/ScoringFiles/PGS003692.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018296 PGS003681
(L_molecular_layer_HP_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left molecular layer hippocampus proper head volume — — R²: 0.02047 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018297 PGS003682
(L_molecular_layer_HP_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left molecular layer hippocampus proper body volume — — R²: 0.00935 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018317 PGS003683
(R_molecular_layer_HP_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right molecular layer hippocampus proper head volume — — R²: 0.01761 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018318 PGS003684
(R_molecular_layer_HP_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right molecular layer hippocampus proper body volume — — R²: 0.01361 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018340 PGS003685
(L_molecular_layer_HP_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left molecular layer hippocampus proper head volume — — R²: 0.00923 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018341 PGS003686
(L_molecular_layer_HP_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left molecular layer hippocampus proper body volume — — R²: 0.00701 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018361 PGS003687
(R_molecular_layer_HP_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right molecular layer hippocampus proper head volume — — R²: 0.01188 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018362 PGS003688
(R_molecular_layer_HP_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right molecular layer hippocampus proper body volume — — R²: 0.01243 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018384 PGS003689
(L_molecular_layer_HP_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left molecular layer hippocampus proper head volume — — R²: 0.00673 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018385 PGS003690
(L_molecular_layer_HP_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left molecular layer hippocampus proper body volume — — R²: 0.00534 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018405 PGS003691
(R_molecular_layer_HP_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right molecular layer hippocampus proper head volume — — R²: 0.00607 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018406 PGS003692
(R_molecular_layer_HP_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right molecular layer hippocampus proper body volume — — R²: 0.00656 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010958 — — 1,999 individuals — East Asian — CHIMGEN —