Trait: mean reticulocyte volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010701
Description Mean volume of reticulocyte cells
Trait category
Hematological measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000180
(mrv)
PGP000078 |
Vuckovic D et al. Cell (2020)
Mean reticulocyte volume mean reticulocyte volume 629
-
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000180/ScoringFiles/PGS000180.txt.gz
PGS000987
(GBE_INI30260)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Mean reticulocyte volume mean reticulocyte volume 13,277
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000987/ScoringFiles/PGS000987.txt.gz
PGS002003
(portability-PLR_reticulocyte_volume)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Mean reticulocyte volume mean reticulocyte volume 24,536
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002003/ScoringFiles/PGS002003.txt.gz
PGS002221
(portability-ldpred2_reticulocyte_volume)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Mean reticulocyte volume mean reticulocyte volume 523,074
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002221/ScoringFiles/PGS002221.txt.gz
PGS003567
(cont-decay-reticulocyte_volume)
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Mean reticulocyte volume mean reticulocyte volume 979,739
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003567/ScoringFiles/PGS003567.txt.gz
PGS003948
(INI30260)
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Mean reticulocyte volume mean reticulocyte volume 18,832
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003948/ScoringFiles/PGS003948.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007703 PGS000987
(GBE_INI30260)
PSS007026|
African Ancestry|
5,973 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean reticulocyte volume : 0.03718 [0.02815, 0.0462]
Incremental R2 (full-covars): 0.02777
PGS R2 (no covariates): 0.02867 [0.02068, 0.03667]
age, sex, UKB array type, Genotype PCs
PPM007704 PGS000987
(GBE_INI30260)
PSS007027|
East Asian Ancestry|
1,623 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean reticulocyte volume : 0.08812 [0.06247, 0.11377]
Incremental R2 (full-covars): 0.07173
PGS R2 (no covariates): 0.07447 [0.05053, 0.0984]
age, sex, UKB array type, Genotype PCs
PPM007705 PGS000987
(GBE_INI30260)
PSS007028|
European Ancestry|
23,687 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean reticulocyte volume : 0.1616 [0.15323, 0.16997]
Incremental R2 (full-covars): 0.14435
PGS R2 (no covariates): 0.1455 [0.1374, 0.15359]
age, sex, UKB array type, Genotype PCs
PPM007706 PGS000987
(GBE_INI30260)
PSS007029|
South Asian Ancestry|
7,323 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean reticulocyte volume : 0.13294 [0.11894, 0.14694]
Incremental R2 (full-covars): 0.09343
PGS R2 (no covariates): 0.09786 [0.08537, 0.11036]
age, sex, UKB array type, Genotype PCs
PPM007707 PGS000987
(GBE_INI30260)
PSS007030|
European Ancestry|
64,570 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Mean reticulocyte volume : 0.15675 [0.15171, 0.16179]
Incremental R2 (full-covars): 0.14554
PGS R2 (no covariates): 0.14631 [0.14138, 0.15124]
age, sex, UKB array type, Genotype PCs
PPM010898 PGS002003
(portability-PLR_reticulocyte_volume)
PSS009487|
European Ancestry|
19,120 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3934 [0.3814, 0.4054] sex, age, birth date, deprivation index, 16 PCs
PPM010899 PGS002003
(portability-PLR_reticulocyte_volume)
PSS009261|
European Ancestry|
3,924 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3882 [0.3612, 0.4145] sex, age, birth date, deprivation index, 16 PCs
PPM010900 PGS002003
(portability-PLR_reticulocyte_volume)
PSS008815|
European Ancestry|
6,298 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3774 [0.356, 0.3984] sex, age, birth date, deprivation index, 16 PCs
PPM010901 PGS002003
(portability-PLR_reticulocyte_volume)
PSS008589|
Greater Middle Eastern Ancestry|
1,127 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3348 [0.2815, 0.3861] sex, age, birth date, deprivation index, 16 PCs
PPM010902 PGS002003
(portability-PLR_reticulocyte_volume)
PSS008367|
South Asian Ancestry|
5,935 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3217 [0.2986, 0.3443] sex, age, birth date, deprivation index, 16 PCs
PPM010903 PGS002003
(portability-PLR_reticulocyte_volume)
PSS008143|
East Asian Ancestry|
1,722 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.2638 [0.219, 0.3074] sex, age, birth date, deprivation index, 16 PCs
PPM010904 PGS002003
(portability-PLR_reticulocyte_volume)
PSS007931|
African Ancestry|
2,293 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.2125 [0.1729, 0.2514] sex, age, birth date, deprivation index, 16 PCs
PPM010905 PGS002003
(portability-PLR_reticulocyte_volume)
PSS009035|
African Ancestry|
3,602 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.1616 [0.1296, 0.1934] sex, age, birth date, deprivation index, 16 PCs
PPM012614 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS009487|
European Ancestry|
19,120 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3894 [0.3773, 0.4014] sex, age, birth date, deprivation index, 16 PCs
PPM012615 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS009261|
European Ancestry|
3,924 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3877 [0.3608, 0.4141] sex, age, birth date, deprivation index, 16 PCs
PPM012616 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS008815|
European Ancestry|
6,298 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3736 [0.3521, 0.3947] sex, age, birth date, deprivation index, 16 PCs
PPM012617 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS008589|
Greater Middle Eastern Ancestry|
1,127 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3308 [0.2773, 0.3823] sex, age, birth date, deprivation index, 16 PCs
PPM012618 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS008367|
South Asian Ancestry|
5,935 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.3152 [0.2921, 0.338] sex, age, birth date, deprivation index, 16 PCs
PPM012619 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS008143|
East Asian Ancestry|
1,722 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.2541 [0.2091, 0.298] sex, age, birth date, deprivation index, 16 PCs
PPM012620 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS007931|
African Ancestry|
2,293 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.2118 [0.1722, 0.2507] sex, age, birth date, deprivation index, 16 PCs
PPM012621 PGS002221
(portability-ldpred2_reticulocyte_volume)
PSS009035|
African Ancestry|
3,602 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Mean reticulocyte volume Partial Correlation (partial-r): 0.1834 [0.1516, 0.2149] sex, age, birth date, deprivation index, 16 PCs
PPM017495 PGS003567
(cont-decay-reticulocyte_volume)
PSS010934|
European Ancestry|
19,112 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.15 sex, age, deprivation index, PC1-16
PPM017579 PGS003567
(cont-decay-reticulocyte_volume)
PSS010850|
European Ancestry|
3,913 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.15 sex, age, deprivation index, PC1-16
PPM017663 PGS003567
(cont-decay-reticulocyte_volume)
PSS010682|
European Ancestry|
6,144 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.13 sex, age, deprivation index, PC1-16
PPM017747 PGS003567
(cont-decay-reticulocyte_volume)
PSS010598|
Greater Middle Eastern Ancestry|
1,097 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.1 sex, age, deprivation index, PC1-16
PPM017831 PGS003567
(cont-decay-reticulocyte_volume)
PSS010262|
European Ancestry|
2,221 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.16 sex, age, deprivation index, PC1-16
PPM017915 PGS003567
(cont-decay-reticulocyte_volume)
PSS010514|
South Asian Ancestry|
5,886 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.1 sex, age, deprivation index, PC1-16
PPM017999 PGS003567
(cont-decay-reticulocyte_volume)
PSS010430|
East Asian Ancestry|
1,711 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.06 sex, age, deprivation index, PC1-16
PPM018083 PGS003567
(cont-decay-reticulocyte_volume)
PSS010346|
African Ancestry|
2,281 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.04 sex, age, deprivation index, PC1-16
PPM018167 PGS003567
(cont-decay-reticulocyte_volume)
PSS010766|
African Ancestry|
3,574 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Mean reticulocyte volume partial-R2: 0.03 sex, age, deprivation index, PC1-16
PPM019059 PGS003948
(INI30260)
PSS011140|
European Ancestry|
64,861 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Mean reticulocyte volume : 0.16087 [0.1558, 0.16594]
PGS R2 (no covariates): 0.14603 [0.14111, 0.15095]
Incremental R2 (full-covars): 0.14515
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)
PPM019060 PGS003948
(INI30260)
PSS011099|
European Ancestry|
2,770 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Mean reticulocyte volume : 0.17217 [0.14717, 0.19717]
PGS R2 (no covariates): 0.14414 [0.1205, 0.16779]
Incremental R2 (full-covars): 0.14281
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)
PPM019061 PGS003948
(INI30260)
PSS011111|
South Asian Ancestry|
1,393 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Mean reticulocyte volume : 0.13781 [0.10535, 0.17027]
PGS R2 (no covariates): 0.11019 [0.08024, 0.14015]
Incremental R2 (full-covars): 0.10391
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)
PPM019062 PGS003948
(INI30260)
PSS011152|
African Ancestry|
1,124 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Mean reticulocyte volume : 0.03874 [0.01751, 0.05997]
PGS R2 (no covariates): 0.03349 [0.01364, 0.05333]
Incremental R2 (full-covars): 0.033
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)
PPM019063 PGS003948
(INI30260)
PSS011169|
Multi-ancestry (excluding European)|
7,578 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Mean reticulocyte volume : 0.15509 [0.14052, 0.16966]
PGS R2 (no covariates): 0.13046 [0.11671, 0.14422]
Incremental R2 (full-covars): 0.11887
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011140 64,861 individuals European
(white British ancestry)
UKB
PSS009035 3,602 individuals African unspecified Nigeria (West Africa) UKB
PSS008143 1,722 individuals East Asian China (East Asia) UKB
PSS011152 1,124 individuals African unspecified UKB
PSS010934 19,112 individuals,
46.0 % Male samples
Mean = 56.9 years
Sd = 7.9 years
European white British UKB
PSS010682 6,144 individuals,
45.0 % Male samples
Mean = 54.4 years
Sd = 8.4 years
European Italian UKB
PSS011169 7,578 individuals East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB
PSS010430 1,711 individuals,
33.0 % Male samples
Mean = 52.4 years
Sd = 7.8 years
East Asian Chinese UKB
PSS008815 6,298 individuals European Italy (South Europe) UKB
PSS007026 5,973 individuals African unspecified UKB
PSS007931 2,293 individuals African American or Afro-Caribbean Carribean UKB
PSS007027 1,623 individuals East Asian UKB
PSS007028 23,687 individuals European non-white British ancestry UKB
PSS007029 7,323 individuals South Asian UKB
PSS007030 64,570 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS010850 3,913 individuals,
38.0 % Male samples
Mean = 54.3 years
Sd = 7.5 years
European Polish UKB
PSS010598 1,097 individuals,
59.0 % Male samples
Mean = 52.0 years
Sd = 8.0 years
Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB
PSS008589 1,127 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009487 19,120 individuals European UK (+ Ireland) UKB
PSS010346 2,281 individuals,
37.0 % Male samples
Mean = 52.4 years
Sd = 8.0 years
African American or Afro-Caribbean Caribbean UKB
PSS011099 2,770 individuals European
(non-white British ancestry)
UKB
PSS011111 1,393 individuals South Asian UKB
PSS009261 3,924 individuals European Poland (NE Europe) UKB
PSS008367 5,935 individuals South Asian India (South Asia) UKB
PSS010766 3,574 individuals,
47.0 % Male samples
Mean = 51.9 years
Sd = 8.1 years
African unspecified Nigerian UKB
PSS010514 5,886 individuals,
55.0 % Male samples
Mean = 53.3 years
Sd = 8.4 years
South Asian Indian UKB
PSS010262 2,221 individuals,
45.0 % Male samples
Mean = 58.0 years
Sd = 7.1 years
European Ashkenazi UKB