Trait: mean reticulocyte volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010701
Description Mean volume of reticulocyte cells
Trait category
Hematological measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000180
(mrv)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Mean reticulocyte volume mean reticulocyte volume 629
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000180/ScoringFiles/PGS000180.txt.gz
PGS000987
(GBE_INI30260)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Mean reticulocyte volume mean reticulocyte volume 13,277
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000987/ScoringFiles/PGS000987.txt.gz
PGS002003
(portability-PLR_reticulocyte_volume)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean reticulocyte volume mean reticulocyte volume 24,536
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002003/ScoringFiles/PGS002003.txt.gz
PGS002221
(portability-ldpred2_reticulocyte_volume)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean reticulocyte volume mean reticulocyte volume 523,074
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002221/ScoringFiles/PGS002221.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007703 PGS000987
(GBE_INI30260)
 PSS007026|
African Ancestry|
5,973 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.03718 [0.02815, 0.0462]
Incremental R2 (full-covars): 0.02777
PGS R2 (no covariates): 0.02867 [0.02068, 0.03667]		 age, sex, UKB array type, Genotype PCs —
PPM007704 PGS000987
(GBE_INI30260)
 PSS007027|
East Asian Ancestry|
1,623 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.08812 [0.06247, 0.11377]
Incremental R2 (full-covars): 0.07173
PGS R2 (no covariates): 0.07447 [0.05053, 0.0984]		 age, sex, UKB array type, Genotype PCs —
PPM007705 PGS000987
(GBE_INI30260)
 PSS007028|
European Ancestry|
23,687 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.1616 [0.15323, 0.16997]
Incremental R2 (full-covars): 0.14435
PGS R2 (no covariates): 0.1455 [0.1374, 0.15359]		 age, sex, UKB array type, Genotype PCs —
PPM007706 PGS000987
(GBE_INI30260)
 PSS007029|
South Asian Ancestry|
7,323 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.13294 [0.11894, 0.14694]
Incremental R2 (full-covars): 0.09343
PGS R2 (no covariates): 0.09786 [0.08537, 0.11036]		 age, sex, UKB array type, Genotype PCs —
PPM007707 PGS000987
(GBE_INI30260)
 PSS007030|
European Ancestry|
64,570 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.15675 [0.15171, 0.16179]
Incremental R2 (full-covars): 0.14554
PGS R2 (no covariates): 0.14631 [0.14138, 0.15124]		 age, sex, UKB array type, Genotype PCs —
PPM010898 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS009487|
European Ancestry|
19,120 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3934 [0.3814, 0.4054] sex, age, birth date, deprivation index, 16 PCs —
PPM010899 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS009261|
European Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3882 [0.3612, 0.4145] sex, age, birth date, deprivation index, 16 PCs —
PPM010900 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008815|
European Ancestry|
6,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3774 [0.356, 0.3984] sex, age, birth date, deprivation index, 16 PCs —
PPM010901 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008589|
Greater Middle Eastern Ancestry|
1,127 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3348 [0.2815, 0.3861] sex, age, birth date, deprivation index, 16 PCs —
PPM010902 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008367|
South Asian Ancestry|
5,935 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3217 [0.2986, 0.3443] sex, age, birth date, deprivation index, 16 PCs —
PPM010903 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008143|
East Asian Ancestry|
1,722 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2638 [0.219, 0.3074] sex, age, birth date, deprivation index, 16 PCs —
PPM010904 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS007931|
African Ancestry|
2,293 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2125 [0.1729, 0.2514] sex, age, birth date, deprivation index, 16 PCs —
PPM010905 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS009035|
African Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.1616 [0.1296, 0.1934] sex, age, birth date, deprivation index, 16 PCs —
PPM012614 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS009487|
European Ancestry|
19,120 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3894 [0.3773, 0.4014] sex, age, birth date, deprivation index, 16 PCs —
PPM012615 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS009261|
European Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3877 [0.3608, 0.4141] sex, age, birth date, deprivation index, 16 PCs —
PPM012616 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008815|
European Ancestry|
6,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3736 [0.3521, 0.3947] sex, age, birth date, deprivation index, 16 PCs —
PPM012617 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008589|
Greater Middle Eastern Ancestry|
1,127 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3308 [0.2773, 0.3823] sex, age, birth date, deprivation index, 16 PCs —
PPM012618 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008367|
South Asian Ancestry|
5,935 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3152 [0.2921, 0.338] sex, age, birth date, deprivation index, 16 PCs —
PPM012619 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008143|
East Asian Ancestry|
1,722 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2541 [0.2091, 0.298] sex, age, birth date, deprivation index, 16 PCs —
PPM012620 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS007931|
African Ancestry|
2,293 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2118 [0.1722, 0.2507] sex, age, birth date, deprivation index, 16 PCs —
PPM012621 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS009035|
African Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.1834 [0.1516, 0.2149] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009035 — — 3,602 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009261 — — 3,924 individuals — European Poland (NE Europe) UKB —
PSS008589 — — 1,127 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009487 — — 19,120 individuals — European UK (+ Ireland) UKB —
PSS008815 — — 6,298 individuals — European Italy (South Europe) UKB —
PSS008367 — — 5,935 individuals — South Asian India (South Asia) UKB —
PSS008143 — — 1,722 individuals — East Asian China (East Asia) UKB —
PSS007931 — — 2,293 individuals — African American or Afro-Caribbean Carribean UKB —
PSS007026 — — 5,973 individuals — African unspecified — UKB —
PSS007027 — — 1,623 individuals — East Asian — UKB —
PSS007028 — — 23,687 individuals — European non-white British ancestry UKB —
PSS007029 — — 7,323 individuals — South Asian — UKB —
PSS007030 — — 64,570 individuals — European white British ancestry UKB Testing cohort (heldout set)