Trait: response to radiation

Trait Information
Identifier GO_0009314
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus.
Trait category
Biological process
Mapped term GO:0009314

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000950
(GBE_HC1171)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Skin changes due to chronic exposure to nonionising radiation (time-to-event) response to radiation 169
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000950/ScoringFiles/PGS000950.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007574 PGS000950
(GBE_HC1171)
PSS004163|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE skin changes due to chronic exposure to nonionising radiation AUROC: 0.7986 [0.66831, 0.9289] : 0.07289
Incremental AUROC (full-covars): -0.00483
PGS R2 (no covariates): 0.0037
PGS AUROC (no covariates): 0.43607 [0.26599, 0.60615]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007575 PGS000950
(GBE_HC1171)
PSS004164|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE skin changes due to chronic exposure to nonionising radiation AUROC: 0.71374 [0.60185, 0.82563] : 0.03768
Incremental AUROC (full-covars): 0.00075
PGS R2 (no covariates): 0.00291
PGS AUROC (no covariates): 0.56978 [0.40767, 0.73189]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007576 PGS000950
(GBE_HC1171)
PSS004165|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE skin changes due to chronic exposure to nonionising radiation AUROC: 0.68867 [0.67287, 0.70447] : 0.05974
Incremental AUROC (full-covars): 0.01376
PGS R2 (no covariates): 0.01894
PGS AUROC (no covariates): 0.61159 [0.59382, 0.62937]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007577 PGS000950
(GBE_HC1171)
PSS004166|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE skin changes due to chronic exposure to nonionising radiation AUROC: 0.69762 [0.60805, 0.78718] : 0.0473
Incremental AUROC (full-covars): 0.0039
PGS R2 (no covariates): 7e-05
PGS AUROC (no covariates): 0.50078 [0.40515, 0.59641]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007578 PGS000950
(GBE_HC1171)
PSS004167|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE skin changes due to chronic exposure to nonionising radiation AUROC: 0.6853 [0.67565, 0.69495] : 0.06036
Incremental AUROC (full-covars): 0.01019
PGS R2 (no covariates): 0.00689
PGS AUROC (no covariates): 0.563 [0.55189, 0.57411]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004163
[
  • 9 cases
  • , 6,488 controls
]
African unspecified UKB
PSS004164
[
  • 11 cases
  • , 1,693 controls
]
East Asian UKB
PSS004165
[
  • 964 cases
  • , 23,941 controls
]
European non-white British ancestry UKB
PSS004166
[
  • 32 cases
  • , 7,799 controls
]
South Asian UKB
PSS004167
[
  • 2,714 cases
  • , 64,711 controls
]
European white British ancestry UKB Testing cohort (heldout set)