Trait: Iridocyclitis

Trait Information
Identifier HP_0001094
Description A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body.
Trait category
Other trait
Mapped terms 3 mapped terms
  • MSH:D015863
  • SNOMEDCT_US:77971008
  • UMLS:C0022073

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000941
(GBE_HC868)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Iridocyclitis (time-to-event) Iridocyclitis 1
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000941/ScoringFiles/PGS000941.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007531 PGS000941
(GBE_HC868)
 PSS004667|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE iridocyclitis — AUROC: 0.68898 [0.62053, 0.75743] PGS R2 (no covariates): 0.00183
Incremental AUROC (full-covars): 0.00666
R²: 0.04292
PGS AUROC (no covariates): 0.50378 [0.48811, 0.51944]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007532 PGS000941
(GBE_HC868)
 PSS004668|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE iridocyclitis — AUROC: 0.8465 [0.65581, 1.0] R²: 0.16291
Incremental AUROC (full-covars): -0.00024
PGS R2 (no covariates): 0.00141
PGS AUROC (no covariates): 0.49529 [0.49299, 0.49759]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007533 PGS000941
(GBE_HC868)
 PSS004669|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE iridocyclitis — AUROC: 0.67429 [0.6184, 0.73017] R²: 0.04715
Incremental AUROC (full-covars): 0.08652
PGS R2 (no covariates): 0.04197
PGS AUROC (no covariates): 0.62279 [0.57834, 0.66724]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007534 PGS000941
(GBE_HC868)
 PSS004670|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE iridocyclitis — AUROC: 0.67356 [0.61463, 0.73249] R²: 0.03247
Incremental AUROC (full-covars): -0.00127
PGS R2 (no covariates): 0.0
PGS AUROC (no covariates): 0.49832 [0.48312, 0.51352]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007535 PGS000941
(GBE_HC868)
 PSS004671|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE iridocyclitis — AUROC: 0.66117 [0.62955, 0.69278] R²: 0.0447
Incremental AUROC (full-covars): 0.10569
PGS R2 (no covariates): 0.04482
PGS AUROC (no covariates): 0.63375 [0.60929, 0.65822]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004668 — —
[
  • 5 cases
  • , 1,699 controls
]
 — East Asian — UKB —
PSS004669 — —
[
  • 106 cases
  • , 24,799 controls
]
 — European non-white British ancestry UKB —
PSS004670 — —
[
  • 65 cases
  • , 7,766 controls
]
 — South Asian — UKB —
PSS004671 — —
[
  • 367 cases
  • , 67,058 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS004667 — —
[
  • 63 cases
  • , 6,434 controls
]
 — African unspecified — UKB —