Trait: Hallux valgus

Trait Information
Identifier HP_0001822
Description Lateral deviation of the great toe (i.e., in the direction of the little toe). [HPO: curators]
Trait category
Other trait
Synonyms 3 synonyms
  • Bunion
  • Lateral deviation of great toe
  • Lateral deviation of halluces
Mapped terms 6 mapped terms
  • MSH:D000071378
  • MSH:D006215
  • SNOMEDCT_US:122480009
  • SNOMEDCT_US:415692008
  • UMLS:C0006386
  • UMLS:C0018536

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001881
(portability-PLR_735.3)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Hallux valgus (Bunion) Hallux valgus 4,527
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001881/ScoringFiles/PGS001881.txt.gz
PGS002093
(portability-ldpred2_735.3)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Hallux valgus (Bunion) Hallux valgus 773,461
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002093/ScoringFiles/PGS002093.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009932 PGS001881
(portability-PLR_735.3)
PSS009358|
European Ancestry|
19,732 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0379 [0.024, 0.0519] sex, age, birth date, deprivation index, 16 PCs
PPM009933 PGS001881
(portability-PLR_735.3)
PSS009132|
European Ancestry|
4,086 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0205 [-0.0103, 0.0512] sex, age, birth date, deprivation index, 16 PCs
PPM009934 PGS001881
(portability-PLR_735.3)
PSS008686|
European Ancestry|
6,598 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0217 [-0.0025, 0.0458] sex, age, birth date, deprivation index, 16 PCs
PPM009935 PGS001881
(portability-PLR_735.3)
PSS008460|
Greater Middle Eastern Ancestry|
1,186 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0299 [-0.0276, 0.0872] sex, age, birth date, deprivation index, 16 PCs
PPM009936 PGS001881
(portability-PLR_735.3)
PSS008240|
South Asian Ancestry|
6,269 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.031 [0.0062, 0.0558] sex, age, birth date, deprivation index, 16 PCs
PPM009937 PGS001881
(portability-PLR_735.3)
PSS008018|
East Asian Ancestry|
1,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0133 [-0.0331, 0.0597] sex, age, birth date, deprivation index, 16 PCs
PPM009938 PGS001881
(portability-PLR_735.3)
PSS007804|
African Ancestry|
2,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0105 [-0.0292, 0.0502] sex, age, birth date, deprivation index, 16 PCs
PPM009939 PGS001881
(portability-PLR_735.3)
PSS008908|
African Ancestry|
3,900 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0008 [-0.0307, 0.0323] sex, age, birth date, deprivation index, 16 PCs
PPM011600 PGS002093
(portability-ldpred2_735.3)
PSS009358|
European Ancestry|
19,732 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0506 [0.0367, 0.0645] sex, age, birth date, deprivation index, 16 PCs
PPM011601 PGS002093
(portability-ldpred2_735.3)
PSS009132|
European Ancestry|
4,086 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0316 sex, age, birth date, deprivation index, 16 PCs
PPM011602 PGS002093
(portability-ldpred2_735.3)
PSS008686|
European Ancestry|
6,598 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.031 [0.0069, 0.0551] sex, age, birth date, deprivation index, 16 PCs
PPM011603 PGS002093
(portability-ldpred2_735.3)
PSS008460|
Greater Middle Eastern Ancestry|
1,186 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0429 [-0.0146, 0.1] sex, age, birth date, deprivation index, 16 PCs
PPM011604 PGS002093
(portability-ldpred2_735.3)
PSS008240|
South Asian Ancestry|
6,269 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0363 [0.0115, 0.0611] sex, age, birth date, deprivation index, 16 PCs
PPM011605 PGS002093
(portability-ldpred2_735.3)
PSS008018|
East Asian Ancestry|
1,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0193 [-0.0271, 0.0657] sex, age, birth date, deprivation index, 16 PCs
PPM011606 PGS002093
(portability-ldpred2_735.3)
PSS007804|
African Ancestry|
2,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): -0.0044 [-0.0441, 0.0353] sex, age, birth date, deprivation index, 16 PCs
PPM011607 PGS002093
(portability-ldpred2_735.3)
PSS008908|
African Ancestry|
3,900 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Hallux valgus (Bunion) Partial Correlation (partial-r): 0.0246 [-0.0068, 0.056] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009132 4,086 individuals European Poland (NE Europe) UKB
PSS008460 1,186 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009358 19,732 individuals European UK (+ Ireland) UKB
PSS008686 6,598 individuals European Italy (South Europe) UKB
PSS008240 6,269 individuals South Asian India (South Asia) UKB
PSS008908 3,900 individuals African unspecified Nigeria (West Africa) UKB
PSS008018 1,803 individuals East Asian China (East Asia) UKB
PSS007804 2,457 individuals African American or Afro-Caribbean Carribean UKB