Trait: Nasal polyposis

Trait Information
Identifier HP_0100582
Description Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis. [HPO: sdoelken] [PMID: 18728843]
Trait category
Other trait
Synonyms 3 synonyms
  • Nasal polyps
  • Polyposis nasi
  • Polys of nose
Mapped terms 3 mapped terms
  • MSH:D009298
  • SNOMEDCT_US:52756005
  • UMLS:C0027430

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000933
(GBE_HC1024)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Nasal polyp (time-to-event) Nasal polyposis 433
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000933/ScoringFiles/PGS000933.txt.gz
PGS000934
(GBE_HC156)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Nasal polyps Nasal polyposis 129
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000934/ScoringFiles/PGS000934.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007501 PGS000934
(GBE_HC156)
PSS004281|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Nasal polyps AUROC: 0.64859 [0.63074, 0.66643] : 0.02916
Incremental AUROC (full-covars): 0.02257
PGS R2 (no covariates): 0.00975
PGS AUROC (no covariates): 0.58621 [0.56789, 0.60453]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007500 PGS000934
(GBE_HC156)
PSS004280|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Nasal polyps AUROC: 0.6332 [0.57742, 0.68897] : 0.02262
Incremental AUROC (full-covars): 0.01134
PGS R2 (no covariates): 0.00545
PGS AUROC (no covariates): 0.57902 [0.52247, 0.63558]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007499 PGS000934
(GBE_HC156)
PSS004279|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Nasal polyps AUROC: 0.63328 [0.60284, 0.66372] : 0.02259
Incremental AUROC (full-covars): 0.02586
PGS R2 (no covariates): 0.00942
PGS AUROC (no covariates): 0.58779 [0.55667, 0.61891]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007498 PGS000934
(GBE_HC156)
PSS004278|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Nasal polyps AUROC: 0.69967 [0.52462, 0.87472] : 0.03703
Incremental AUROC (full-covars): 0.0
PGS R2 (no covariates): 0.01108
PGS AUROC (no covariates): 0.62251 [0.4395, 0.80552]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007497 PGS000934
(GBE_HC156)
PSS004277|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Nasal polyps AUROC: 0.65827 [0.58248, 0.73405] : 0.0287
Incremental AUROC (full-covars): -0.00544
PGS R2 (no covariates): 1e-05
PGS AUROC (no covariates): 0.49669 [0.40936, 0.58401]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007496 PGS000933
(GBE_HC1024)
PSS004078|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE nasal polyp AUROC: 0.67606 [0.65938, 0.69275] : 0.04173
Incremental AUROC (full-covars): 0.04228
PGS R2 (no covariates): 0.01964
PGS AUROC (no covariates): 0.62534 [0.60798, 0.6427]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007495 PGS000933
(GBE_HC1024)
PSS004077|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE nasal polyp AUROC: 0.68977 [0.63369, 0.74584] : 0.04721
Incremental AUROC (full-covars): 0.01714
PGS R2 (no covariates): 0.01383
PGS AUROC (no covariates): 0.61037 [0.55084, 0.6699]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007494 PGS000933
(GBE_HC1024)
PSS004076|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE nasal polyp AUROC: 0.66224 [0.63308, 0.69139] : 0.03382
Incremental AUROC (full-covars): 0.04299
PGS R2 (no covariates): 0.0183
PGS AUROC (no covariates): 0.6261 [0.59502, 0.65718]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007493 PGS000933
(GBE_HC1024)
PSS004075|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE nasal polyp AUROC: 0.79304 [0.65773, 0.92835] : 0.12147
Incremental AUROC (full-covars): 0.04938
PGS R2 (no covariates): 0.02455
PGS AUROC (no covariates): 0.68691 [0.49033, 0.88349]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007492 PGS000933
(GBE_HC1024)
PSS004074|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE nasal polyp AUROC: 0.59241 [0.49967, 0.68514] : 0.00952
Incremental AUROC (full-covars): -0.05119
PGS R2 (no covariates): 0.00091
PGS AUROC (no covariates): 0.48954 [0.39183, 0.58724]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004074
[
  • 40 cases
  • , 6,457 controls
]
African unspecified UKB
PSS004075
[
  • 8 cases
  • , 1,696 controls
]
East Asian UKB
PSS004076
[
  • 328 cases
  • , 24,577 controls
]
European non-white British ancestry UKB
PSS004077
[
  • 82 cases
  • , 7,749 controls
]
South Asian UKB
PSS004078
[
  • 975 cases
  • , 66,450 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004277
[
  • 40 cases
  • , 6,457 controls
]
African unspecified UKB
PSS004278
[
  • 11 cases
  • , 1,693 controls
]
East Asian UKB
PSS004279
[
  • 340 cases
  • , 24,565 controls
]
European non-white British ancestry UKB
PSS004280
[
  • 95 cases
  • , 7,736 controls
]
South Asian UKB
PSS004281
[
  • 944 cases
  • , 66,481 controls
]
European white British ancestry UKB Testing cohort (heldout set)