Trait: arteriosclerosis disorder

Trait Information
Identifier MONDO_0002277
Description A vascular disorder characterized by thickening and hardening of the walls of the arteries. [NCIT: C34398]
Trait category
Other trait
Synonyms 4 synonyms
  • arterial sclerosis
  • arteriosclerosis
  • arteriosclerotic cardiovascular disease
  • vascular sclerosis
Child trait(s) coronary atherosclerosis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "arteriosclerosis disorder" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001839
(portability-PLR_411.4)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Coronary atherosclerosis coronary atherosclerosis 25,425
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001839/ScoringFiles/PGS001839.txt.gz
PGS002048
(portability-ldpred2_411.4)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Coronary atherosclerosis coronary atherosclerosis 762,124
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002048/ScoringFiles/PGS002048.txt.gz
PGS019165
(TPMI_411.4_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Coronary atherosclerosis coronary atherosclerosis 18,489
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019165/ScoringFiles/PGS019165.txt.gz
PGS019166
(TPMI_411.4_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Coronary atherosclerosis coronary atherosclerosis 939,870
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019166/ScoringFiles/PGS019166.txt.gz
PGS019167
(TPMI_411.4_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Coronary atherosclerosis coronary atherosclerosis 31,979
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019167/ScoringFiles/PGS019167.txt.gz
PGS019168
(TPMI_411.4_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Coronary atherosclerosis coronary atherosclerosis 983,811
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019168/ScoringFiles/PGS019168.txt.gz
PGS019169
(TPMI_411.4_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Coronary atherosclerosis coronary atherosclerosis 941,902
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019169/ScoringFiles/PGS019169.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009602 PGS001839
(portability-PLR_411.4)
 PSS009311|
European Ancestry|
19,308 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1021 [0.0881, 0.1161] sex, age, birth date, deprivation index, 16 PCs —
PPM009603 PGS001839
(portability-PLR_411.4)
 PSS009085|
European Ancestry|
4,021 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1391 [0.1086, 0.1693] sex, age, birth date, deprivation index, 16 PCs —
PPM009604 PGS001839
(portability-PLR_411.4)
 PSS008639|
European Ancestry|
6,492 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0994 [0.0753, 0.1235] sex, age, birth date, deprivation index, 16 PCs —
PPM009605 PGS001839
(portability-PLR_411.4)
 PSS008413|
Greater Middle Eastern Ancestry|
1,158 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0815 [0.0235, 0.1389] sex, age, birth date, deprivation index, 16 PCs —
PPM009607 PGS001839
(portability-PLR_411.4)
 PSS007975|
East Asian Ancestry|
1,794 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0452 [-0.0014, 0.0915] sex, age, birth date, deprivation index, 16 PCs —
PPM009608 PGS001839
(portability-PLR_411.4)
 PSS007758|
African Ancestry|
2,396 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0269 [-0.0133, 0.067] sex, age, birth date, deprivation index, 16 PCs —
PPM009609 PGS001839
(portability-PLR_411.4)
 PSS008862|
African Ancestry|
3,793 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0157 [-0.0163, 0.0475] sex, age, birth date, deprivation index, 16 PCs —
PPM009606 PGS001839
(portability-PLR_411.4)
 PSS008193|
South Asian Ancestry|
6,070 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1113 [0.0863, 0.1361] sex, age, birth date, deprivation index, 16 PCs —
PPM011246 PGS002048
(portability-ldpred2_411.4)
 PSS009311|
European Ancestry|
19,308 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1078 [0.0938, 0.1217] sex, age, birth date, deprivation index, 16 PCs —
PPM011247 PGS002048
(portability-ldpred2_411.4)
 PSS009085|
European Ancestry|
4,021 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1435 [0.113, 0.1737] sex, age, birth date, deprivation index, 16 PCs —
PPM011248 PGS002048
(portability-ldpred2_411.4)
 PSS008639|
European Ancestry|
6,492 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1061 [0.0819, 0.1301] sex, age, birth date, deprivation index, 16 PCs —
PPM011250 PGS002048
(portability-ldpred2_411.4)
 PSS008193|
South Asian Ancestry|
6,070 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.1246 [0.0997, 0.1493] sex, age, birth date, deprivation index, 16 PCs —
PPM011251 PGS002048
(portability-ldpred2_411.4)
 PSS007975|
East Asian Ancestry|
1,794 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0522 [0.0057, 0.0985] sex, age, birth date, deprivation index, 16 PCs —
PPM011252 PGS002048
(portability-ldpred2_411.4)
 PSS007758|
African Ancestry|
2,396 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0358 [-0.0044, 0.0759] sex, age, birth date, deprivation index, 16 PCs —
PPM011253 PGS002048
(portability-ldpred2_411.4)
 PSS008862|
African Ancestry|
3,793 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.01 [-0.0219, 0.0419] sex, age, birth date, deprivation index, 16 PCs —
PPM011249 PGS002048
(portability-ldpred2_411.4)
 PSS008413|
Greater Middle Eastern Ancestry|
1,158 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Coronary atherosclerosis — — Partial Correlation (partial-r): 0.0727 [0.0146, 0.1302] sex, age, birth date, deprivation index, 16 PCs —
PPM037347 PGS019165
(TPMI_411.4_Lassosum2)
 PSS013063|
East Asian Ancestry|
18,061 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Coronary atherosclerosis — AUROC: 0.65583 R²: 0.05877 sex, age, array, PCs 1-10 —
PPM037348 PGS019166
(TPMI_411.4_LDpred2)
 PSS013062|
East Asian Ancestry|
18,061 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Coronary atherosclerosis — AUROC: 0.65898 R²: 0.06045 sex, age, array, PCs 1-10 —
PPM037349 PGS019167
(TPMI_411.4_MegaPRS)
 PSS013064|
East Asian Ancestry|
18,061 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Coronary atherosclerosis — AUROC: 0.6572 R²: 0.05946 sex, age, array, PCs 1-10 —
PPM037350 PGS019168
(TPMI_411.4_PRS-CS)
 PSS013065|
East Asian Ancestry|
18,061 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Coronary atherosclerosis — AUROC: 0.65935 R²: 0.06076 sex, age, array, PCs 1-10 —
PPM037351 PGS019169
(TPMI_411.4_SBayesR)
 PSS013066|
East Asian Ancestry|
18,061 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Coronary atherosclerosis — AUROC: 0.65377 R²: 0.05819 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007975 — — 1,794 individuals — East Asian China (East Asia) UKB —
PSS008413 — — 1,158 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS013062 411.81, 414.0, 414.1, 414.2, 414.3, 414.4, 996.03, V45.81, V45.82,I24.0, I25.1, I25.3, I25.4, I25.700, I25.701, I25.708, I25.709, I25.710, I25.711, I25.718, I25.719, I25.720, I25.721, I25.728, I25.729, I25.730, I25.731, I25.738, I25.739, I25.790, I25.791, I25.798, I25.799, I25.810, I25.82, I25.83, I25.84, Z95.1, Z95.5, Z98.6 —
[
  • 1,431 cases
  • , 16,630 controls
]
,
44.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007758 — — 2,396 individuals — African American or Afro-Caribbean Carribean UKB —
PSS013063 411.81, 414.0, 414.1, 414.2, 414.3, 414.4, 996.03, V45.81, V45.82,I24.0, I25.1, I25.3, I25.4, I25.700, I25.701, I25.708, I25.709, I25.710, I25.711, I25.718, I25.719, I25.720, I25.721, I25.728, I25.729, I25.730, I25.731, I25.738, I25.739, I25.790, I25.791, I25.798, I25.799, I25.810, I25.82, I25.83, I25.84, Z95.1, Z95.5, Z98.6 —
[
  • 1,431 cases
  • , 16,630 controls
]
,
44.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013064 411.81, 414.0, 414.1, 414.2, 414.3, 414.4, 996.03, V45.81, V45.82,I24.0, I25.1, I25.3, I25.4, I25.700, I25.701, I25.708, I25.709, I25.710, I25.711, I25.718, I25.719, I25.720, I25.721, I25.728, I25.729, I25.730, I25.731, I25.738, I25.739, I25.790, I25.791, I25.798, I25.799, I25.810, I25.82, I25.83, I25.84, Z95.1, Z95.5, Z98.6 —
[
  • 1,431 cases
  • , 16,630 controls
]
,
44.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013065 411.81, 414.0, 414.1, 414.2, 414.3, 414.4, 996.03, V45.81, V45.82,I24.0, I25.1, I25.3, I25.4, I25.700, I25.701, I25.708, I25.709, I25.710, I25.711, I25.718, I25.719, I25.720, I25.721, I25.728, I25.729, I25.730, I25.731, I25.738, I25.739, I25.790, I25.791, I25.798, I25.799, I25.810, I25.82, I25.83, I25.84, Z95.1, Z95.5, Z98.6 —
[
  • 1,431 cases
  • , 16,630 controls
]
,
44.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013066 411.81, 414.0, 414.1, 414.2, 414.3, 414.4, 996.03, V45.81, V45.82,I24.0, I25.1, I25.3, I25.4, I25.700, I25.701, I25.708, I25.709, I25.710, I25.711, I25.718, I25.719, I25.720, I25.721, I25.728, I25.729, I25.730, I25.731, I25.738, I25.739, I25.790, I25.791, I25.798, I25.799, I25.810, I25.82, I25.83, I25.84, Z95.1, Z95.5, Z98.6 —
[
  • 1,431 cases
  • , 16,630 controls
]
,
44.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008639 — — 6,492 individuals — European Italy (South Europe) UKB —
PSS009085 — — 4,021 individuals — European Poland (NE Europe) UKB —
PSS008862 — — 3,793 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009311 — — 19,308 individuals — European UK (+ Ireland) UKB —
PSS008193 — — 6,070 individuals — South Asian India (South Asia) UKB —