Trait: middle ear disorder

Trait Information
Identifier MONDO_0003276
Description A disease involving the middle ear.
Trait category
Other trait
Synonyms 6 synonyms
  • disease of middle ear
  • disease or disorder of middle ear
  • disorder of middle ear
  • middle Ear disorder
  • middle ear disease
  • middle ear disease or disorder
Child trait(s) otitis media

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "middle ear disorder" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019076
(TPMI_381.11_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 46,921
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019076/ScoringFiles/PGS019076.txt.gz
PGS019077
(TPMI_381.11_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 939,893
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019077/ScoringFiles/PGS019077.txt.gz
PGS019078
(TPMI_381.11_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 486,781
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019078/ScoringFiles/PGS019078.txt.gz
PGS019079
(TPMI_381.11_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019079/ScoringFiles/PGS019079.txt.gz
PGS019080
(TPMI_381.11_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 999,521
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019080/ScoringFiles/PGS019080.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037258 PGS019076
(TPMI_381.11_Lassosum2)
 PSS012979|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63418 R²: 0.01229 sex, age, array, PCs 1-10 —
PPM037259 PGS019077
(TPMI_381.11_LDpred2)
 PSS012978|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63992 R²: 0.01294 sex, age, array, PCs 1-10 —
PPM037260 PGS019078
(TPMI_381.11_MegaPRS)
 PSS012980|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63614 R²: 0.01221 sex, age, array, PCs 1-10 —
PPM037261 PGS019079
(TPMI_381.11_PRS-CS)
 PSS012981|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63258 R²: 0.01178 sex, age, array, PCs 1-10 —
PPM037262 PGS019080
(TPMI_381.11_SBayesR)
 PSS012982|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63187 R²: 0.0115 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012978 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012979 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012980 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012981 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012982 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —