Trait: arterial occlusion

Trait Information
Identifier MONDO_0020673
Description Complete closure of the normally patent lumen of the blood vessels which carry blood away from the heart. [NCIT: C35318]
Trait categories
Cardiovascular disease
Other disease
Synonyms 2 synonyms
  • arterial obstruction
  • arterial occlusion
Child trait(s) cerebral artery occlusion

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "arterial occlusion" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019230
(TPMI_433.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Occlusion of cerebral arteries cerebral artery occlusion 562,676
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019230/ScoringFiles/PGS019230.txt.gz
PGS019231
(TPMI_433.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Occlusion of cerebral arteries cerebral artery occlusion 939,882
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019231/ScoringFiles/PGS019231.txt.gz
PGS019232
(TPMI_433.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Occlusion of cerebral arteries cerebral artery occlusion 33,950
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019232/ScoringFiles/PGS019232.txt.gz
PGS019233
(TPMI_433.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Occlusion of cerebral arteries cerebral artery occlusion 983,818
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019233/ScoringFiles/PGS019233.txt.gz
PGS019234
(TPMI_433.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Occlusion of cerebral arteries cerebral artery occlusion 969,384
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019234/ScoringFiles/PGS019234.txt.gz
PGS019250
(TPMI_433.21_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cerebral artery occlusion with cerebral infarction cerebral artery occlusion 48,064
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019250/ScoringFiles/PGS019250.txt.gz
PGS019251
(TPMI_433.21_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cerebral artery occlusion with cerebral infarction cerebral artery occlusion 939,870
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019251/ScoringFiles/PGS019251.txt.gz
PGS019252
(TPMI_433.21_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cerebral artery occlusion with cerebral infarction cerebral artery occlusion 23,452
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019252/ScoringFiles/PGS019252.txt.gz
PGS019253
(TPMI_433.21_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cerebral artery occlusion with cerebral infarction cerebral artery occlusion 983,812
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019253/ScoringFiles/PGS019253.txt.gz
PGS019254
(TPMI_433.21_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cerebral artery occlusion with cerebral infarction cerebral artery occlusion 976,798
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019254/ScoringFiles/PGS019254.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037412 PGS019230
(TPMI_433.2_Lassosum2)
 PSS013133|
East Asian Ancestry|
18,165 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Occlusion of cerebral arteries — AUROC: 0.64904 R²: 0.05282 sex, age, array, PCs 1-10 —
PPM037413 PGS019231
(TPMI_433.2_LDpred2)
 PSS013132|
East Asian Ancestry|
18,165 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Occlusion of cerebral arteries — AUROC: 0.64962 R²: 0.0533 sex, age, array, PCs 1-10 —
PPM037414 PGS019232
(TPMI_433.2_MegaPRS)
 PSS013134|
East Asian Ancestry|
18,165 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Occlusion of cerebral arteries — AUROC: 0.64321 R²: 0.04993 sex, age, array, PCs 1-10 —
PPM037415 PGS019233
(TPMI_433.2_PRS-CS)
 PSS013135|
East Asian Ancestry|
18,165 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Occlusion of cerebral arteries — AUROC: 0.65154 R²: 0.05411 sex, age, array, PCs 1-10 —
PPM037416 PGS019234
(TPMI_433.2_SBayesR)
 PSS013136|
East Asian Ancestry|
18,165 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Occlusion of cerebral arteries — AUROC: 0.64638 R²: 0.05144 sex, age, array, PCs 1-10 —
PPM037432 PGS019250
(TPMI_433.21_Lassosum2)
 PSS013128|
East Asian Ancestry|
17,922 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cerebral artery occlusion with cerebral infarction — AUROC: 0.66398 R²: 0.03769 sex, age, array, PCs 1-10 —
PPM037433 PGS019251
(TPMI_433.21_LDpred2)
 PSS013127|
East Asian Ancestry|
17,922 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cerebral artery occlusion with cerebral infarction — AUROC: 0.66506 R²: 0.03875 sex, age, array, PCs 1-10 —
PPM037434 PGS019252
(TPMI_433.21_MegaPRS)
 PSS013129|
East Asian Ancestry|
17,922 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cerebral artery occlusion with cerebral infarction — AUROC: 0.66288 R²: 0.03706 sex, age, array, PCs 1-10 —
PPM037435 PGS019253
(TPMI_433.21_PRS-CS)
 PSS013130|
East Asian Ancestry|
17,922 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cerebral artery occlusion with cerebral infarction — AUROC: 0.67066 R²: 0.04063 sex, age, array, PCs 1-10 —
PPM037436 PGS019254
(TPMI_433.21_SBayesR)
 PSS013131|
East Asian Ancestry|
17,922 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cerebral artery occlusion with cerebral infarction — AUROC: 0.66335 R²: 0.03789 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013127 434.01, 434.11, 434.91,I63.0, I63.3, I63.4, I63.5, I63.6, I63.8, I63.9 —
[
  • 606 cases
  • , 17,316 controls
]
,
45.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013128 434.01, 434.11, 434.91,I63.0, I63.3, I63.4, I63.5, I63.6, I63.8, I63.9 —
[
  • 606 cases
  • , 17,316 controls
]
,
45.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013129 434.01, 434.11, 434.91,I63.0, I63.3, I63.4, I63.5, I63.6, I63.8, I63.9 —
[
  • 606 cases
  • , 17,316 controls
]
,
45.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013130 434.01, 434.11, 434.91,I63.0, I63.3, I63.4, I63.5, I63.6, I63.8, I63.9 —
[
  • 606 cases
  • , 17,316 controls
]
,
45.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013131 434.01, 434.11, 434.91,I63.0, I63.3, I63.4, I63.5, I63.6, I63.8, I63.9 —
[
  • 606 cases
  • , 17,316 controls
]
,
45.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013132 434, 437.6,I63, I66, I67.6 —
[
  • 849 cases
  • , 17,316 controls
]
,
45.55 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013133 434, 437.6,I63, I66, I67.6 —
[
  • 849 cases
  • , 17,316 controls
]
,
45.55 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013134 434, 437.6,I63, I66, I67.6 —
[
  • 849 cases
  • , 17,316 controls
]
,
45.55 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013135 434, 437.6,I63, I66, I67.6 —
[
  • 849 cases
  • , 17,316 controls
]
,
45.55 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013136 434, 437.6,I63, I66, I67.6 —
[
  • 849 cases
  • , 17,316 controls
]
,
45.55 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —