Trait: tracheobronchitis

Trait Information
Identifier MONDO_0021925
Description Inflammation of the tracheobronchial tree. [NCIT: C122784]
Trait category
Other disease
Synonym tracheobronchitis
Child trait(s) bronchitis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "tracheobronchitis" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019290
(TPMI_497_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 255,924
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019290/ScoringFiles/PGS019290.txt.gz
PGS019291
(TPMI_497_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 275,948
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019291/ScoringFiles/PGS019291.txt.gz
PGS019292
(TPMI_497_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 531,558
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019292/ScoringFiles/PGS019292.txt.gz
PGS019293
(TPMI_497_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 983,817
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019293/ScoringFiles/PGS019293.txt.gz
PGS019294
(TPMI_497_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Bronchitis bronchitis 962,291
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019294/ScoringFiles/PGS019294.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037472 PGS019290
(TPMI_497_Lassosum2)
 PSS013193|
East Asian Ancestry|
17,705 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Bronchitis — AUROC: 0.5695 R²: 0.00873 sex, age, array, PCs 1-10 —
PPM037473 PGS019291
(TPMI_497_LDpred2)
 PSS013192|
East Asian Ancestry|
17,705 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Bronchitis — AUROC: 0.56667 R²: 0.00819 sex, age, array, PCs 1-10 —
PPM037474 PGS019292
(TPMI_497_MegaPRS)
 PSS013194|
East Asian Ancestry|
17,705 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Bronchitis — AUROC: 0.56754 R²: 0.0083 sex, age, array, PCs 1-10 —
PPM037475 PGS019293
(TPMI_497_PRS-CS)
 PSS013195|
East Asian Ancestry|
17,705 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Bronchitis — AUROC: 0.56987 R²: 0.0087 sex, age, array, PCs 1-10 —
PPM037476 PGS019294
(TPMI_497_SBayesR)
 PSS013196|
East Asian Ancestry|
17,705 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Bronchitis — AUROC: 0.56679 R²: 0.00814 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013192 490,J40 —
[
  • 595 cases
  • , 17,110 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013193 490,J40 —
[
  • 595 cases
  • , 17,110 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013194 490,J40 —
[
  • 595 cases
  • , 17,110 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013195 490,J40 —
[
  • 595 cases
  • , 17,110 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013196 490,J40 —
[
  • 595 cases
  • , 17,110 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —