Trait: hypertension, pregnancy-induced

Trait Information
Identifier MONDO_0024664
Description A hypertensive disorder that develops during pregnancy. [NCIT: C9243]
Trait category
Other trait
Synonyms 13 synonyms
  • gestational hypertension
  • hypertension associated disorders of pregnancy
  • hypertension, gestational
  • hypertension, pregnancy induced
  • hypertension, pregnancy transient
  • hypertension-associated pregnancy disorder
  • hypertensions, pregnancy induced
  • induced Hypertensions, pregnancy
  • induced hypertension, pregnancy
  • pregnancy induced hypertension
  • pregnancy transient hypertension
  • pregnancy-induced hypertension
  • transient hypertension, pregnancy
Child trait(s) preeclampsia

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "hypertension, pregnancy-induced" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003586
(PE)
 PGP000462 |
Honigberg MC et al. Nat Med (2023)
 Pre-eclampsia preeclampsia 1,087,033
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003586/ScoringFiles/PGS003586.txt.gz
PGS003587
(GH)
 PGP000462 |
Honigberg MC et al. Nat Med (2023)
 Gestational hypertension preeclampsia 1,087,916
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003587/ScoringFiles/PGS003587.txt.gz
PGS004593
(pe)
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Preeclampsia preeclampsia 1,102,059
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004593/ScoringFiles/PGS004593.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018280 PGS003586
(PE)
 PSS010956|
European Ancestry|
25,582 individuals
 PGP000462 |
Honigberg MC et al. Nat Med (2023)
 Reported Trait: Pre-eclampsia/eclampsia OR: 1.31 [1.24, 1.38] — — maternal age at delivery, age2, and the first ten principal components of genetic ancestry —
PPM018281 PGS003587
(GH)
 PSS010956|
European Ancestry|
25,582 individuals
 PGP000462 |
Honigberg MC et al. Nat Med (2023)
 Reported Trait: Pre-eclampsia/eclampsia OR: 1.2 [1.14, 1.26] — — maternal age at delivery, age2, and the first ten principal components of genetic ancestry —
PPM020743 PGS004593
(pe)
 PSS011387|
European Ancestry|
138,317 individuals
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Reported Trait: Gestational hypertension HR: 1.16 [1.14, 1.19] — — Collection year, genotyping batch, and the first 10 genetic principal components —
PPM020744 PGS004593
(pe)
 PSS011388|
European Ancestry|
136,354 individuals
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Reported Trait: Preeclampsia HR: 1.21 [1.18, 1.24] — — Collection year, genotyping batch, and the first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011387 — —
[
  • 8,488 cases
  • , 129,829 controls
]
,
0.0 % Male samples
 — European
(Finnish)		 — FinnGen —
PSS011388 — —
[
  • 6,643 cases
  • , 129,711 controls
]
,
0.0 % Male samples
 — European
(Finnish)		 — FinnGen —
PSS010956 — —
[
  • 1,569 cases
  • , 24,013 controls
]
 — European — HUNT —