Trait: digestive system infectious disorder

Trait Information
Identifier MONDO_0043424
Description A viral, bacterial, fungal, or parasitic infectious process that affects the digestive system. [NCIT: C35503]
Trait categories
Digestive system disorder
Other disease
Synonyms 3 synonyms
  • digestive system infection
  • gastrointestinal infection
  • gastrointestinal system infection
Child trait(s) 2 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "digestive system infectious disorder" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018419
(TPMI_070_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis viral hepatitis 1,584
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018419/ScoringFiles/PGS018419.txt.gz
PGS018420
(TPMI_070_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis viral hepatitis 939,805
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018420/ScoringFiles/PGS018420.txt.gz
PGS018421
(TPMI_070_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis viral hepatitis 49,513
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018421/ScoringFiles/PGS018421.txt.gz
PGS018422
(TPMI_070_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis viral hepatitis 983,768
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018422/ScoringFiles/PGS018422.txt.gz
PGS018423
(TPMI_070_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis viral hepatitis 136,488
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018423/ScoringFiles/PGS018423.txt.gz
PGS018424
(TPMI_070.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 4,575
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018424/ScoringFiles/PGS018424.txt.gz
PGS018425
(TPMI_070.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 939,797
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018425/ScoringFiles/PGS018425.txt.gz
PGS018426
(TPMI_070.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 253,455
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018426/ScoringFiles/PGS018426.txt.gz
PGS018427
(TPMI_070.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 983,762
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018427/ScoringFiles/PGS018427.txt.gz
PGS018428
(TPMI_070.2_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 1,071,340
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018428/ScoringFiles/PGS018428.txt.gz
PGS018429
(TPMI_070.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral hepatitis B hepatitis B virus infection 73,098
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018429/ScoringFiles/PGS018429.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036601 PGS018419
(TPMI_070_Lassosum2)
 PSS012338|
East Asian Ancestry|
18,392 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis — AUROC: 0.66584 R²: 0.09632 sex, age, array, PCs 1-10 —
PPM036602 PGS018420
(TPMI_070_LDpred2)
 PSS012337|
East Asian Ancestry|
18,392 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis — AUROC: 0.66706 R²: 0.09753 sex, age, array, PCs 1-10 —
PPM036603 PGS018421
(TPMI_070_MegaPRS)
 PSS012339|
East Asian Ancestry|
18,392 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis — AUROC: 0.65859 R²: 0.08984 sex, age, array, PCs 1-10 —
PPM036604 PGS018422
(TPMI_070_PRS-CS)
 PSS012340|
East Asian Ancestry|
18,392 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis — AUROC: 0.66524 R²: 0.09576 sex, age, array, PCs 1-10 —
PPM036605 PGS018423
(TPMI_070_SBayesR)
 PSS012341|
East Asian Ancestry|
18,392 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis — AUROC: 0.66205 R²: 0.09237 sex, age, array, PCs 1-10 —
PPM036606 PGS018424
(TPMI_070.2_Lassosum2)
 PSS012322|
East Asian Ancestry|
16,415 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis B — AUROC: 0.73149 R²: 0.12951 sex, age, array, PCs 1-10 —
PPM036607 PGS018425
(TPMI_070.2_LDpred2)
 PSS012321|
East Asian Ancestry|
16,415 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis B — AUROC: 0.73251 R²: 0.13063 sex, age, array, PCs 1-10 —
PPM036608 PGS018426
(TPMI_070.2_MegaPRS)
 PSS012323|
East Asian Ancestry|
16,415 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis B — AUROC: 0.70874 R²: 0.10883 sex, age, array, PCs 1-10 —
PPM036609 PGS018427
(TPMI_070.2_PRS-CS)
 PSS012324|
East Asian Ancestry|
16,415 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis B — AUROC: 0.72807 R²: 0.12453 sex, age, array, PCs 1-10 —
PPM036610 PGS018428
(TPMI_070.2_PRSmix+)
 PSS012325|
East Asian Ancestry|
16,415 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis B — AUROC: 0.73833 R²: 0.13621 sex, age, array, PCs 1-10 —
PPM036611 PGS018429
(TPMI_070.2_SBayesR)
 PSS012326|
East Asian Ancestry|
16,415 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral hepatitis B — AUROC: 0.71321 R²: 0.11347 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012321 070.2, 070.3,B16, B18.0, B18.1, B19.1 —
[
  • 1,504 cases
  • , 14,911 controls
]
,
46.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012322 070.2, 070.3,B16, B18.0, B18.1, B19.1 —
[
  • 1,504 cases
  • , 14,911 controls
]
,
46.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012323 070.2, 070.3,B16, B18.0, B18.1, B19.1 —
[
  • 1,504 cases
  • , 14,911 controls
]
,
46.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012324 070.2, 070.3,B16, B18.0, B18.1, B19.1 —
[
  • 1,504 cases
  • , 14,911 controls
]
,
46.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012325 070.2, 070.3,B16, B18.0, B18.1, B19.1 —
[
  • 1,504 cases
  • , 14,911 controls
]
,
46.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012326 070.2, 070.3,B16, B18.0, B18.1, B19.1 —
[
  • 1,504 cases
  • , 14,911 controls
]
,
46.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012337 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 —
[
  • 3,481 cases
  • , 14,911 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012338 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 —
[
  • 3,481 cases
  • , 14,911 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012339 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 —
[
  • 3,481 cases
  • , 14,911 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012340 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 —
[
  • 3,481 cases
  • , 14,911 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012341 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 —
[
  • 3,481 cases
  • , 14,911 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —