Trait: Ischemic stroke


Experimental Factor Ontology ID: HP_0002140

EFO Trait Description: None

Associated PGS

Polygenic Score (PGS) ID PGS Name Publication ID Reported Trait Mapped Trait(s) (EFO) Number of Variants PGS Download Links
PGS000039 metaGRS_ischaemicstroke Abraham G et al. bioRxiv (2019) Ischaemic stroke Ischemic stroke 3,225,583 FTP Link

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000091 PGS000039 (metaGRS_ischaemicstroke) PSS000058 Abraham G et al. (2019) Reported Trait: Ischaemic stroke before age 75 HR: 1.26 [1.22 - 1.31] C-index: 0.585 [0.574 - 0.595] Sex, genotyping chip, 10 PCs

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000058 Prevalent and incident Ischaemic stroke; defined in 395,393 individuals
[ 3,075 cases, 392,318 controls]
45.70 %% Male samples
European UKB Validation set