PGS Publication: PGP000010

Publication Information (EuropePMC)
Title Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores.
PubMed ID 27513194(Europe PMC)
doi 10.1038/gim.2016.103
Publication Date Aug. 11, 2016
Journal Genet Med
Author(s) Läll K, Mägi R, Morris A, Metspalu A, Fischer K.
Released in PGS Catalog: Oct. 14, 2019

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000020
(dGRS1000)
 PGP000010 |
Läll K et al. Genet Med (2016)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 7,502
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000020/ScoringFiles/PGS000020.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000040 PGS000020
(dGRS1000)
 PSS000025|
European Ancestry|
6,280 individuals
 PGP000010 |
Läll K et al. Genet Med (2016)
 Reported Trait: Incident type 2 diabetes HR: 1.48 [1.32, 1.66] C-index: 0.79 [0.771, 0.812] — BMI category, smoking level, waist-to-hip ratio, waist circumference, physical activity level, history of high blood glucose, fruit and vegetable consumption, and sex. Cox age-as-time-scale

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000025 Incident cases of Type 2 Diabetes in 5.63 years follow-up —
[
  • 302 cases
  • , 5,978 controls
]
,
55.0 % Male samples
 — European
(Estonian)		 — EB —