PGS Publication: PGP000074

Publication Information (EuropePMC)
Title Evaluating the effect of multiple genetic risk score models on colorectal cancer risk prediction.
PubMed ID 29908285(Europe PMC)
doi 10.1016/j.gene.2018.06.035
Publication Date June 14, 2018
Journal Gene
Author(s) Xin J, Chu H, Ben S, Ge Y, Shao W, Zhao Y, Wei Y, Ma G, Li S, Gu D, Zhang Z, Du M, Wang M.
Released in PGS Catalog: April 29, 2020

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000151
(SC_GRS)
 PGP000074 |
Xin J et al. Gene (2018)
 Colorectal cancer colorectal cancer 14
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000151/ScoringFiles/PGS000151.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000471 PGS000151
(SC_GRS)
 PSS000271|
East Asian Ancestry|
3,523 individuals
 PGP000074 |
Xin J et al. Gene (2018)
 Reported Trait: Colorectal cancer — AUROC: 0.607 [0.581, 0.633] — smoking status —
PPM000470 PGS000151
(SC_GRS)
 PSS000271|
East Asian Ancestry|
3,523 individuals
 PGP000074 |
Xin J et al. Gene (2018)
 Reported Trait: Colorectal cancer — AUROC: 0.6 [0.579, 0.622] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000271 — —
[
  • 1,316 cases
  • , 2,207 controls
]
,
40.85 % Male samples
 Mean (Cases) = 58.34 years
Sd (Cases) = 12.85 years		 East Asian
(Han Chinese)		 — NCRCC —